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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS06625 [old locus tag: SPH_1367 ]
  • pan locus tag?: PNEUPAN002506000
  • symbol: SPH_RS06625
  • pan gene symbol?: mcrB
  • synonym:
  • product: McrB family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS06625 [old locus tag: SPH_1367 ]
  • symbol: SPH_RS06625
  • product: McrB family protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1269286..1271217
  • length: 1932
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_010380 (1269286..1271217) NCBI
  • BioCyc: SPH_RS06625 BioCyc
  • MicrobesOnline: see SPH_1367
  • PneumoBrowse for strain D39V: SPV_1109 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    ATGAATAAAAGAAAAGTTAGTTTAGAAGATTTTTATAAATGGTATAGTCTAAATAAAGAA
    GAGTTATTAAATAAGGCAACTGTTGGTGAAAAGTTTAATGATAAATTAAAAGAAGAGTTT
    CTCCAGGAATGGCCTTTGGATAGGATTTTAACAATGTCAATCGATGAATATGTAATAGGA
    AAGGGACAGCAAAATAAGTCTTTATGCTACGCTCTTGAGAAGGGAAAATACAAAAATCTA
    TTTCTTGGAATTTCTGGTGGCTCAGCTTCAAAATTTGGTATTTATTGGAATAAAAAAACA
    AACAAATATAAAGATCAAGCTAATAATGAGATTTCAGAGTTGGATCAGCGATTTTCAAAA
    TTAAAATCAGATTTGTATGAAATTATCAAAGAAGGTATTCGTTTTAACTTTGAAAATCCT
    ATTTTTGATATGAAAAGATCAACAAATGAATTTATTGGTCGTTCTGCTATGGTGACAAAA
    TTACTTTGTATCTATACTGAGGGAGATCCTTTCTTTGGTGTAAATATTAATAGTCAGAAA
    GAATTTTGGAACCACTTTGTTTCTCAGACAAATCAAGGTGGACCTTATCTGCAAAATCAT
    AAAATAATTGAACTGGTGTCCAAAACTTATCCTGAGTTGGAGCCATCGAAATTAGGAACT
    ATGCTTTTTGAGTATTCTAAGCTTTTTATGGAAAATAAGGAAGACAATAGTACAATGGAT
    TCATCAAACAATTTTAGTCATCAATTAACTCAATCTCTATTAAAGTCTCCAAACCTTATC
    CTTCGTGGTGCTCCTGGCACAGGAAAGACTTATCTTGCTAAAGAAATTGCCAAAGAATTA
    ACGGATGGCAACGAAGACCAAATCGGATTTGTACAATTTCACCCATCCTATGATTATACG
    GATTTTGTAGAAGGTTTAAGACCAGTATCAAATGGGGATGGAGCTATTGAGTTTAGGCTA
    CAGGACGGTATTTTTAAAGATTTTTGTCAGAAAGCAAAAGAACCCCAATTGATTGGAGGA
    CAAGATAATTTTGATGAGGCTTGGGATTCTTACTTAGAATATATAAATGTTGCTGAAGAA
    AAAGAATATATAACAAAAACATCTTACTTATCTGTTAATAGTAGACAAAATTTGTCAGTA
    AATTATGATAGTGGTGTTCCAGGATGGTCACTACCTAGCAAATATGTTTACGAGTTGTAT
    AAAGATAAAAATTATAATAAGCAAGAATACTACAAAAGTGGTGGAAAAACTGTCCTAGAA
    ACATTGAGAAAGAGATTTGGTTTGAAAGACTATGTTTCCCCAACAGAAATTGATACTGAT
    AAGAAATTCGTCTTCATCATCGATGAAATCAATCGTGGGGAGATTTCTAAGATTTTTGGC
    GAACTCTTTTTCTCTATCGACCCTGGCTATCGTGGTGAAAAAGGAAGTGTTTCTACCCAA
    TATGCAAATCTACACGAAACTGATGAAAAGTTCTATATCCCCGAAAATGTTTACATCATC
    GGAACTATGAATGATATTGATCGTTCAGTGGATACCTTTGATTTTGCTATGCGTCGTCGT
    TTTCGTTTTGTTGAAGTTACTGCCGAGGGTCAAGTTGGCATGTTGGATAAAGAGTTGAAT
    ATCCATGCAGAAGAAGCAAAAATTCGTCTAAGAAACTTGAACGCTGCTATCGAAAATGTT
    CAGGAATTAAACAGTCATTATCATATTGGACCAAGTTATTTTCTTAAGTTGAAGGATGTA
    GATTTTGACTATGAATTACTCTGGTCTGATTATATTAAGCCTCTCCTAGAAGACTACTTG
    CGAGGTTCTTATGATGAGGTTGAAACTTTGGAAACTTTGAAAAAAGCATTTGATCTGACA
    AATAATGAGCAAAAAGATCAGGCAGTAGCTGATGACAATGAAGGCGATGAAAACGATGAT
    GCGGATTACTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1932

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_RS06625 [old locus tag: SPH_1367 ]
  • symbol: SPH_RS06625
  • description: McrB family protein
  • length: 643
  • theoretical pI: 4.68774
  • theoretical MW: 74606.9
  • GRAVY: -0.689269

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein synthesis tRNA aminoacylation L-seryl-tRNA(Sec) kinase (TIGR03574; EC 2.7.1.164; HMM-score: 17.4)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent Clp protease, ATP-binding subunit ClpX (TIGR00382; HMM-score: 16.8)
    Genetic information processing Protein fate Protein folding and stabilization ATP-dependent Clp protease, ATP-binding subunit ClpX (TIGR00382; HMM-score: 16.8)
    26S proteasome subunit P45 family (TIGR01242; HMM-score: 14.5)
    P-type DNA transfer ATPase VirB11 (TIGR02788; HMM-score: 14.4)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair orc1/cdc6 family replication initiation protein (TIGR02928; HMM-score: 14.2)
    and 5 more
    Cellular processes Cellular processes Cell division ATP-dependent metallopeptidase HflB (TIGR01241; EC 3.4.24.-; HMM-score: 12.8)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent metallopeptidase HflB (TIGR01241; EC 3.4.24.-; HMM-score: 12.8)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides proteasome ATPase (TIGR03689; EC 3.6.4.8; HMM-score: 12.4)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair exodeoxyribonuclease V, alpha subunit (TIGR01447; EC 3.1.11.5; HMM-score: 10.4)
    AAA family ATPase, CDC48 subfamily (TIGR01243; HMM-score: 10.1)
  • TheSEED: see SPH_1367
  • PFAM:
    P-loop_NTPase (CL0023) AAA_5; AAA domain (dynein-related subfamily) (PF07728; HMM-score: 52.3)
    and 26 more
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 26.2)
    NACHT; NACHT domain (PF05729; HMM-score: 21.4)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 20.5)
    AAA_14; AAA domain (PF13173; HMM-score: 19.7)
    AAA_18; AAA domain (PF13238; HMM-score: 18.9)
    RNA_helicase; RNA helicase (PF00910; HMM-score: 17.9)
    TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 17.1)
    no clan defined Imm40; Immunity protein 40 (PF15569; HMM-score: 16.3)
    P-loop_NTPase (CL0023) AAA_22; AAA domain (PF13401; HMM-score: 16.2)
    AAA_19; AAA domain (PF13245; HMM-score: 16.1)
    AAA_33; AAA domain (PF13671; HMM-score: 14.7)
    ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 14.1)
    IstB_IS21; IstB-like ATP binding protein (PF01695; HMM-score: 13.9)
    Mg_chelatase; Magnesium chelatase, subunit ChlI (PF01078; HMM-score: 13.7)
    AAA_30; AAA domain (PF13604; HMM-score: 13.2)
    Zeta_toxin; Zeta toxin (PF06414; HMM-score: 12.8)
    DUF2075; Schlafen group 3, DNA/RNA helicase domain (PF09848; HMM-score: 12.8)
    AAA_7; P-loop containing dynein motor region (PF12775; HMM-score: 12.4)
    AAA_3; ATPase family associated with various cellular activities (AAA) (PF07726; HMM-score: 12.3)
    RuvB_N; Holliday junction DNA helicase RuvB P-loop domain (PF05496; HMM-score: 12.1)
    Torsin; Torsin (PF06309; HMM-score: 12)
    Sigma54_activat; Sigma-54 interaction domain (PF00158; HMM-score: 11.8)
    DnaB_C; DnaB-like helicase C terminal domain (PF03796; HMM-score: 11.3)
    AAA_25; AAA domain (PF13481; HMM-score: 11.3)
    bpMoxR; MoxR domain in the MoxR-vWA-beta-propeller ternary systems (PF20030; HMM-score: 11.3)
    MBD-like (CL0081) Arm-DNA-bind_5; Arm DNA-binding domain (PF17293; HMM-score: 8.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.6546
    • Cytoplasmic Membrane Score: 0.0713
    • Cell wall & surface Score: 0.0091
    • Extracellular Score: 0.265
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.011016
    • TAT(Tat/SPI): 0.000294
    • LIPO(Sec/SPII): 0.000646
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MNKRKVSLEDFYKWYSLNKEELLNKATVGEKFNDKLKEEFLQEWPLDRILTMSIDEYVIGKGQQNKSLCYALEKGKYKNLFLGISGGSASKFGIYWNKKTNKYKDQANNEISELDQRFSKLKSDLYEIIKEGIRFNFENPIFDMKRSTNEFIGRSAMVTKLLCIYTEGDPFFGVNINSQKEFWNHFVSQTNQGGPYLQNHKIIELVSKTYPELEPSKLGTMLFEYSKLFMENKEDNSTMDSSNNFSHQLTQSLLKSPNLILRGAPGTGKTYLAKEIAKELTDGNEDQIGFVQFHPSYDYTDFVEGLRPVSNGDGAIEFRLQDGIFKDFCQKAKEPQLIGGQDNFDEAWDSYLEYINVAEEKEYITKTSYLSVNSRQNLSVNYDSGVPGWSLPSKYVYELYKDKNYNKQEYYKSGGKTVLETLRKRFGLKDYVSPTEIDTDKKFVFIIDEINRGEISKIFGELFFSIDPGYRGEKGSVSTQYANLHETDEKFYIPENVYIIGTMNDIDRSVDTFDFAMRRRFRFVEVTAEGQVGMLDKELNIHAEEAKIRLRNLNAAIENVQELNSHYHIGPSYFLKLKDVDFDYELLWSDYIKPLLEDYLRGSYDEVETLETLKKAFDLTNNEQKDQAVADDNEGDENDDADY

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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