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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS08040 [old locus tag: SPH_1658 ]
  • pan locus tag?: PNEUPAN002828000
  • symbol: SPH_RS08040
  • pan gene symbol?: aspC
  • synonym:
  • product: pyridoxal phosphate-dependent aminotransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS08040 [old locus tag: SPH_1658 ]
  • symbol: SPH_RS08040
  • product: pyridoxal phosphate-dependent aminotransferase
  • replicon: chromosome
  • strand: -
  • coordinates: 1528461..1529648
  • length: 1188
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_010380 (1528461..1529648) NCBI
  • BioCyc: SPH_RS08040 BioCyc
  • MicrobesOnline: see SPH_1658
  • PneumoBrowse for strain D39V: SPV_1373 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGAAATTATCCAACCGTGTTTTAGAAATGGAAGAAAGTGTGACTTTGGCTGCTGGAGCC
    CGTGCCAAAGCACTGAAGGCTGAGGGTAGAGATATTTTGTCTCTAACCTTGGGTGAGCCA
    GATTTCACTACTCCCAAAAATATCCAAGATGCCGCCATTGCATCGATTCGAGATGGGCGT
    GCTTCTTTTTATACAGTAACCTCAGGTCTGCCAGAGCTTAAGGCGGCGGTCAATAGCTAC
    TTTGAGCGCTTTTACGGCTATTCTGTAGCGTCAAATCAAGTGACAGTCGCTGCGGGAGCC
    AAATATTCTCTCTATACCTTCTTTATGGCTGTGGTCAATCCAGGTGATGAAGTCATCATC
    CCAACCCCATACTGGGTTAGCTATGGAGATCAGGTCAAGATGGCAGAAGGCGTTCCCGTC
    TTTGTTTCTGCTAAGGAAGACAATCACTTTAAGGTGACCGTGGAGCAGTTAGAAGCAGCT
    CGGACTGACAAGACCAAGGTTTTGGTGCTGAATTCACCATCTAATCCGACAGGTATGATT
    TACACCCGTGAGGAACTCTTGGCAATCGGAAACTGGGCTGTAGAAAAGGATATTCTCATC
    CTAGCAGATGATATCTATGGCCGCTTGGTCTATAATGGACATGAATTTACACCCATTTCT
    AGCCTATCGGAAGCGATTCGCAAGCAAACAGTGGTCATCAATGGTGTGTCTAAAACCTAT
    GCCATGACTGGTTGGCGGATTGGCTATGCCGTCGGAGAAGCAGACATTATCGCTGCCATG
    TCCAAGATTGCAGGCCAAACAACCTCGAACCCTTCAGCAGTAGCCCAGTATGCAGCAGTT
    GAGGCTCTATCAGGTGAGCAAGATACTGTAGAAAACATGCGTCAGGCCTTTGAAGAGCGA
    CTCAATACCATCTATCCCCTTCTTGCTGAGGTACCAGGATTTGAAGTGGTCAAACCGCAA
    GGAGCCTTCTATCTCTTCCCAAATGTCAAAAAGGGCATGGAGATGAAAGGCTATACGGAT
    GTGACAGACTTTACAACTGCTATCTTAGAAGAAGCCGAAGTGGCCTTGGTAACAGGAGCA
    GGTTTTGGAGCGCCAGAAAATGTCCGCCTCAGCTATGCGACAGACTTAGACACGCTTAAA
    GAAGCAGTTAAACGCTTGAAAGTATTTATGGGTAGTGAGAATGATTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1188

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_RS08040 [old locus tag: SPH_1658 ]
  • symbol: SPH_RS08040
  • description: pyridoxal phosphate-dependent aminotransferase
  • length: 395
  • theoretical pI: 4.58712
  • theoretical MW: 43040.6
  • GRAVY: -0.0493671

⊟Function[edit | edit source]

  • reaction:
    EC 2.6.1.-?  ExPASy
  • TIGRFAM:
    LL-diaminopimelate aminotransferase (TIGR03540; EC 2.6.1.83; HMM-score: 233.2)
    tyrosine/nicotianamine family aminotransferase (TIGR01265; HMM-score: 203.3)
    and 19 more
    Metabolism Energy metabolism Amino acids and amines tyrosine aminotransferase (TIGR01264; EC 2.6.1.5; HMM-score: 177)
    putative C-S lyase (TIGR04350; EC 4.4.-.-; HMM-score: 153)
    succinyldiaminopimelate transaminase (TIGR03537; EC 2.6.1.17; HMM-score: 141.3)
    succinyldiaminopimelate transaminase (TIGR03538; EC 2.6.1.17; HMM-score: 135.5)
    Cellular processes Cellular processes Biosynthesis of natural products capreomycidine synthase (TIGR03947; HMM-score: 128.9)
    Metabolism Amino acid biosynthesis Histidine family histidinol-phosphate transaminase (TIGR01141; EC 2.6.1.9; HMM-score: 118.7)
    succinyldiaminopimelate transaminase (TIGR03539; EC 2.6.1.17; HMM-score: 102.3)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin threonine-phosphate decarboxylase (TIGR01140; EC 4.1.1.81; HMM-score: 96.9)
    beta-methylarginine biosynthesis bifunctional aminotransferase (TIGR04544; EC 2.6.-.-; HMM-score: 88)
    LL-diaminopimelate aminotransferase (TIGR03542; EC 2.6.1.83; HMM-score: 75.1)
    enduracididine biosynthesis enzyme MppQ (TIGR04461; EC 2.-.-.-; HMM-score: 55.7)
    Metabolism Energy metabolism Amino acids and amines aspartate 4-decarboxylase (TIGR03801; EC 4.1.1.12; HMM-score: 49)
    Unknown function Enzymes of unknown specificity cysteine desulfurase family protein (TIGR01977; HMM-score: 23.8)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides TDP-4-keto-6-deoxy-D-glucose transaminase (TIGR02379; HMM-score: 21.3)
    aminotransferase, LLPSF_NHT_00031 family (TIGR04181; HMM-score: 17.3)
    Metabolism Amino acid biosynthesis Aspartate family O-succinylhomoserine sulfhydrylase (TIGR01325; EC 4.2.99.-; HMM-score: 15.7)
    enduracididine biosynthesis enzyme MppP (TIGR04462; EC 2.-.-.-; HMM-score: 14.6)
    Metabolism Energy metabolism Amino acids and amines methionine gamma-lyase (TIGR01328; EC 4.4.1.11; HMM-score: 13.3)
    cysteine desulfurase, NifS family (TIGR03403; EC 2.8.1.7; HMM-score: 11.6)
  • TheSEED: see SPH_1658
  • PFAM:
    PLP_aminotran (CL0061) Aminotran_1_2; Aminotransferase class I and II (PF00155; HMM-score: 238)
    and 4 more
    DegT_DnrJ_EryC1; DegT/DnrJ/EryC1/StrS aminotransferase family (PF01041; HMM-score: 25.4)
    Aminotran_5; Aminotransferase class-V (PF00266; HMM-score: 16.5)
    Cys_Met_Meta_PP; Cys/Met metabolism PLP-dependent enzyme (PF01053; HMM-score: 15.6)
    OKR_DC_1; Orn/Lys/Arg decarboxylase, major domain (PF01276; HMM-score: 14.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9979
    • Cytoplasmic Membrane Score: 0.0002
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0018
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.029116
    • TAT(Tat/SPI): 0.005369
    • LIPO(Sec/SPII): 0.003678
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKLSNRVLEMEESVTLAAGARAKALKAEGRDILSLTLGEPDFTTPKNIQDAAIASIRDGRASFYTVTSGLPELKAAVNSYFERFYGYSVASNQVTVAAGAKYSLYTFFMAVVNPGDEVIIPTPYWVSYGDQVKMAEGVPVFVSAKEDNHFKVTVEQLEAARTDKTKVLVLNSPSNPTGMIYTREELLAIGNWAVEKDILILADDIYGRLVYNGHEFTPISSLSEAIRKQTVVINGVSKTYAMTGWRIGYAVGEADIIAAMSKIAGQTTSNPSAVAQYAAVEALSGEQDTVENMRQAFEERLNTIYPLLAEVPGFEVVKPQGAFYLFPNVKKGMEMKGYTDVTDFTTAILEEAEVALVTGAGFGAPENVRLSYATDLDTLKEAVKRLKVFMGSEND

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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