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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS08735 [old locus tag: SPH_1792 ]
  • pan locus tag?: PNEUPAN003102000
  • symbol: SPH_RS08735
  • pan gene symbol?: iolX_2
  • synonym:
  • product: Gfo/Idh/MocA family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS08735 [old locus tag: SPH_1792 ]
  • symbol: SPH_RS08735
  • product: Gfo/Idh/MocA family protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1654980..1656083
  • length: 1104
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_010380 (1654980..1656083) NCBI
  • BioCyc: SPH_RS08735 BioCyc
  • MicrobesOnline: see SPH_1792
  • PneumoBrowse for strain D39V: SPV_1498 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    ATGGTTAAATATGGTGTTGTTGGAACAGGGTATTTTGGATCTGAATTGGCTCGCTATATG
    CAAAAGAATGATGGAGCAGAGATTACTCTTCTCTATGATCCAGATAATGCAGAGGCGATT
    GCAGAAGAATTGGGAGCAAAAGTAGTAAGCTCCCTAGATGAGTTGGTTTCTAGCGATGAA
    GTAGATTGTGTTATCGTCGCAACTCCAAATAATCTTCATAAGGAACCGGTTATTAAGGCT
    GCACAACATGGTAAAAATGTTTTCTGTGAAAAACCAATTGCGCTTTCTTATCAAGATTGT
    CGCGAGATGGTAGATGCGTGTAAAGAAAACAATGTAACCTTTATGGCAGGACATATTATG
    AATTTCTTTAATGGTGTCCATCATGCAAAAGAACTCATTAATCAAGGAGTTATCGGAGAC
    GTTCTATATTGTCACACAGCTCGTAATGGTTGGGAAGAACAACAACCGTCAGTATCATGG
    AAAAAAATTCGTGAAAAATCAGGTGGTCACTTGTATCACCACATCCATGAGTTGGATTGT
    GTTCAATTCCTTATGGGTGGCATGCCTGAAACTGTAACCATGACAGGTGGAAATGTAGCC
    CATGAAGGTGAACATTTCGGTGATGAAGATGATATGATTTTTGTCAATATGGAATTTTCT
    AATAAGCGTTTTGCCTTGTTAGAATGGGGTTCAGCTTATCGTTGGGGTGAACATTATGTC
    TTAATCCAAGGAACCAAAGGTGCTATCCGCTTAGACTTATTCAACTGTAAAGGAACTCTT
    AAGCTAGATGGGCAAGAAAGCTATTTCTTGATTCATGAATCACAAGAAGAAGATGATGAT
    CGGACTCGTATCTATCATAGTACAGAGATGGACGGAGCGATTGCTTATGGTAAACCAGGT
    AAACGTACTCCATTATGGCTATCATCTGTCATTGACAAAGAAATGCGCTATCTACATGAG
    ATTATGCAAGGAGCTCCAGTATCAGAAGAATTTGCAAAACTATTGACAGGTGAAGCTGCT
    TTAGAAGCGATTGCTACTGCAGATGCTTGTACTCAGTCTATGTTTGAAGATCGCAAAGTA
    AAATTGTCAGAAATTGTAAACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1104

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_RS08735 [old locus tag: SPH_1792 ]
  • symbol: SPH_RS08735
  • description: Gfo/Idh/MocA family protein
  • length: 367
  • theoretical pI: 4.81117
  • theoretical MW: 41138.2
  • GRAVY: -0.340054

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Energy metabolism Sugars inositol 2-dehydrogenase (TIGR04380; EC 1.1.1.18; HMM-score: 136.8)
    and 3 more
    Metabolism Amino acid biosynthesis Serine family phosphoglycerate dehydrogenase (TIGR01327; EC 1.1.1.95; HMM-score: 20.4)
    Metabolism Amino acid biosynthesis Glutamate family N-acetyl-gamma-glutamyl-phosphate reductase (TIGR01850; EC 1.2.1.38; HMM-score: 19.2)
    aspartate dehydrogenase (TIGR03855; EC 1.4.1.21; HMM-score: 17.4)
  • TheSEED: see SPH_1792
  • PFAM:
    GADPH_aa-bio_dh (CL0139) GFO_IDH_MocA_C; Oxidoreductase family, C-terminal alpha/beta domain (PF02894; HMM-score: 200.1)
    and 16 more
    NADP_Rossmann (CL0063) GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold (PF01408; HMM-score: 113.1)
    Semialdhyde_dh; Semialdehyde dehydrogenase, NAD binding domain (PF01118; HMM-score: 32.1)
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent (PF03807; HMM-score: 25.2)
    NAD_binding_3; Homoserine dehydrogenase, NAD binding domain (PF03447; HMM-score: 22.5)
    CoA_binding; CoA binding domain (PF02629; HMM-score: 21.5)
    2-Hacid_dh_C; D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain (PF02826; HMM-score: 21.4)
    NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase (PF03446; HMM-score: 20.6)
    DapB_N; Dihydrodipicolinate reductase, N-terminus (PF01113; HMM-score: 17.1)
    no clan defined DUF6324; Family of unknown function (DUF6324) (PF19849; HMM-score: 16.9)
    NADP_Rossmann (CL0063) Shikimate_DH; Shikimate / quinate 5-dehydrogenase (PF01488; HMM-score: 16.4)
    TrkA_N; TrkA-N domain (PF02254; HMM-score: 15.7)
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase (PF00070; HMM-score: 14.3)
    PDH_N; Prephenate dehydrogenase, nucleotide-binding domain (PF02153; HMM-score: 13.6)
    Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain (PF03435; HMM-score: 13.6)
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase (PF07992; HMM-score: 13)
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain (PF02737; HMM-score: 12.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9852
    • Cytoplasmic Membrane Score: 0.0054
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0094
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004607
    • TAT(Tat/SPI): 0.000139
    • LIPO(Sec/SPII): 0.000768
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MVKYGVVGTGYFGSELARYMQKNDGAEITLLYDPDNAEAIAEELGAKVVSSLDELVSSDEVDCVIVATPNNLHKEPVIKAAQHGKNVFCEKPIALSYQDCREMVDACKENNVTFMAGHIMNFFNGVHHAKELINQGVIGDVLYCHTARNGWEEQQPSVSWKKIREKSGGHLYHHIHELDCVQFLMGGMPETVTMTGGNVAHEGEHFGDEDDMIFVNMEFSNKRFALLEWGSAYRWGEHYVLIQGTKGAIRLDLFNCKGTLKLDGQESYFLIHESQEEDDDRTRIYHSTEMDGAIAYGKPGKRTPLWLSSVIDKEMRYLHEIMQGAPVSEEFAKLLTGEAALEAIATADACTQSMFEDRKVKLSEIVN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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