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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 10-MAR-2021
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae Hungary19A-6
- locus tag: SPH_RS10490 [old locus tag: SPH_2144 ]
- pan locus tag?: PNEUPAN003542000
- symbol: SPH_RS10490
- pan gene symbol?: hk11
- synonym:
- product: sensor histidine kinase
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SPH_RS10490 [old locus tag: SPH_2144 ]
- symbol: SPH_RS10490
- product: sensor histidine kinase
- replicon: chromosome
- strand: -
- coordinates: 1977108..1978205
- length: 1098
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: NC_010380 (1977108..1978205) NCBI
- BioCyc: SPH_RS10490 BioCyc
- MicrobesOnline: see SPH_2144
- PneumoBrowse for strain D39V: SPV_1799 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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1021
1081ATGCTTGAAAGACTGAAAAGCATAGACTATATGTATTGGACCAGTTTGATTTTTATGGTT
TTTCCCATCGTTCCTGTAGTGACTGGGGAGCTTCCTAGCTGGCATTTGTTGATTGACATT
CTGTTTGTCTTGGCTTACTTAGGTGTTTTAACCACCAAGAGTCAGCGTTTATCCTGGCTC
TGTTGGGTGATTATGCTAGCCTATGTAGCTGGGAATACTGCCTTTGTTGGTGTAAATTAT
ATCTGGTTCTTCTTTTTCCTTGCCAATCTCTTAATTTATCATTTCGGCGTGCGTAGTTTT
AATTCTTTACATGTCCGGACTTTTCTCCTTGCTCAATTCCTTGTTGTGGGGCAACTTTTG
ATTTTTCAGGAAGTTGAAGTTGAGTTTCTAGTCTATCTGCTTGGAATTATCACTTTTATC
GATTTAATGACTTTTGGCTTGGTTCGGATTCGTATTGTGGAGGATTTGAAAGAAGCTCAG
GCTAAGCAAAATGCCCAGATAAATCTATTGCTTGCTGAAAATGAACGCAGTCGTATCGGT
CAAGATTTGCATGATAGTCTGGGGCATACCTTTGCTATGCTTAGTGTTAAAACTGATCTA
GCCTTGCAGTTATTTCAAATACAGGCTTATCCACAGGTGGAAAAGGAATTAAGAGAAATA
CAGCAAATTAGCAAAGAATCAATGCGTGAAGTTCGAACCATTGTGGAAAATCTTAAATCT
AGAACTTTGACATCAGAACTAGAGACTGTGAAAAAGATGTTAGAAATTGCTGGAATTGAG
GTGGAAACGGATAACCAACTAGATACTGCTAGCCTAACTCAGAAGTTGGAGTCAACGGCT
TCCATGATTTTGCTTGAATTAGTGACCAATATCATCAAACATGCCCAAGCGTCTAAAGTC
TACTTAAAATTAGAACGGACAGAGAAGGAACTCATTCTAGCAGTAAGTGATGATGGCTGC
GGCTTTGCTTTTCTAAAAGGAGATGAGCTCCATACAATCCGAGATCGTGTTTTTCCATTT
TCAGGAGAAGTAAGTGTAATCAGTCAGAAACATCCAACGGAAGTGCAAGTTCGACTACCT
TATAAGGAGAGAAACTAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SPH_RS10490 [old locus tag: SPH_2144 ]
- symbol: SPH_RS10490
- description: sensor histidine kinase
- length: 365
- theoretical pI: 5.8935
- theoretical MW: 41955.8
- GRAVY: 0.277534
⊟Function[edit | edit source]
- TIGRFAM:
- TheSEED: see SPH_2144
- PFAM: His_Kinase_A (CL0025) HisKA_3; Histidine kinase (PF07730; HMM-score: 60.1)and 3 moreHATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518; HMM-score: 22.7)HATPase_c_2; Histidine kinase-like ATPase domain (PF13581; HMM-score: 20.1)Peptidase_MA (CL0126) Peptidase_M50; Peptidase family M50 (PF02163; HMM-score: 6.2)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic Membrane
- Cytoplasmic Score: 0
- Cytoplasmic Membrane Score: 10
- Cellwall Score: 0
- Extracellular Score: 0
- Internal Helices: 6
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.01614
- TAT(Tat/SPI): 0.000464
- LIPO(Sec/SPII): 0.029667
- predicted transmembrane helices (TMHMM): 6
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MLERLKSIDYMYWTSLIFMVFPIVPVVTGELPSWHLLIDILFVLAYLGVLTTKSQRLSWLCWVIMLAYVAGNTAFVGVNYIWFFFFLANLLIYHFGVRSFNSLHVRTFLLAQFLVVGQLLIFQEVEVEFLVYLLGIITFIDLMTFGLVRIRIVEDLKEAQAKQNAQINLLLAENERSRIGQDLHDSLGHTFAMLSVKTDLALQLFQIQAYPQVEKELREIQQISKESMREVRTIVENLKSRTLTSELETVKKMLEIAGIEVETDNQLDTASLTQKLESTASMILLELVTNIIKHAQASKVYLKLERTEKELILAVSDDGCGFAFLKGDELHTIRDRVFPFSGEVSVISQKHPTEVQVRLPYKERN
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_1799 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
Wolfgang Haas, Deepak Kaushal, Jack Sublett, Caroline Obert, Elaine I Tuomanen
Vancomycin stress response in a sensitive and a tolerant strain of Streptococcus pneumoniae.
J Bacteriol: 2005, 187(23);8205-10
[PubMed:16291696] [WorldCat.org] [DOI] (P p)Riana Cockeran, Jenny A Herbert, Timothy J Mitchell, Thérèse Dix-Peek, Caroline Dickens, Ronald Anderson, Charles Feldman
Exposure of a 23F serotype strain of Streptococcus pneumoniae to cigarette smoke condensate is associated with selective upregulation of genes encoding the two-component regulatory system 11 (TCS11).
Biomed Res Int: 2014, 2014;976347
[PubMed:25013815] [WorldCat.org] [DOI] (I p)