From PneumoWiki
Jump to navigation Jump to search
PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae JJA
  • locus tag: SPJ_1134 [new locus tag: SPJ_RS05645 ]
  • pan locus tag?: PNEUPAN002457000
  • symbol: gyrA
  • pan gene symbol?: gyrA
  • synonym:
  • product: DNA gyrase, A subunit

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPJ_1134 [new locus tag: SPJ_RS05645 ]
  • symbol: gyrA
  • product: DNA gyrase, A subunit
  • replicon: chromosome
  • strand: -
  • coordinates: 1092164..1094632
  • length: 2469
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    ATGCAGGATAAAAATTTAGTGAATGTCAATCTGACAAAGGAGATGAAGGCAAGTTTTATC
    GACTACGCCATGAGTGTTATCGTAGCGCGAGCTCTTCCTGATGTTCGAGATGGCTTAAAA
    CCTGTTCACCGTCGCATTCTCTACGGAATGAATGAATTGGGTGTGACCCCAGACAAACCC
    CATAAAAAATCTGCTCGTATTACAGGGGATGTCATGGGTAAATATCACCCACACGGGGAT
    TCCTCTATTTATGAAGCCATGGTCCGTATGGCTCAATGGTGGAGCTACCGTTACATGCTT
    GTAGATGGTCATGGGAATTTTGGTTCCATGGATGGAGATAGTGCTGCCGCTCAACGTTAT
    ACCGAGGCACGTATGAGCAAGATTGCTCTGGAAATGCTTCGTGATATCAACAAAAATACA
    GTTGATTTCGTTGATAACTATGATGCCAATGAACGGGAACCCTTGGTCTTGCCAGCGCGT
    TTTCCAAACCTTTTGGTTAATGGAGCAACTGGTATCGCGGTTGGGATGGCAACCAATATT
    CCACCTCATAATCTGGGTGAAACCATTGATGCAGTGAAGTTGGTCATGGATAATCCTGAA
    GTGACTACCAAGGACTTGATGGAAGTCTTGCCTGGACCAGATTTTCCAACTGGTGCTCTT
    GTCATGGGGAAATCAGGTATCCATAAGGCTTATGAAACAGGTAAAGGTTCGATTGTCCTA
    CGTTCTCGTACAGAGATTGAAACGACTAAGACTGGTCGTGAGCGTATCGTTGTAACAGAA
    TTTCCTTACATGGTCAATAAAACCAAGGTGCATGAGCATATTGTTCGCTTGGTTCAGGAA
    AAACGCATTGAGGGTATCACAGCAGTACGTGATGAGTCAAACCGTGAAGGTGTTCGATTT
    GTTATTGAAGTCAAGCGCGACGCCTCAGCCAATGTTATTCTCAATAACCTCTTCAAAATG
    ACCCAAATGCAAACCAATTTTGGATTCAATATGCTCGCTATCCAAAATGGTATACCGAAA
    ATTTTGTCTCTTCGTCAGATTTTGGATGCTTATATTGAGCACCAAAAAGAAGTGGTTGTT
    CGTCGTACACGTTTTGATAAGGAAAAAGCGGAAGCGCGCGCTCATATCTTAGAAGGTCTC
    TTGATTGCGCTAGACCATATCGACGAAGTGATTCGTATCATCCGTGCTAGTGAAACGGAT
    GCGGAAGCTCAAGCTGAGTTGATGAGCAAGTTTAAGCTTTCTGAACGTCAAAGTCAAGCT
    ATCCTTGATATGCGTCTTCGTCGTTTGACAGGTTTGGAACGCGATAAGATTCAATCTGAG
    TATGATGACCTCTTGGCTCTGATTGCGGATTTAGCAGATATTCTTGCTAAGCCTGAACGT
    GTTTCTCAAATTATCAAAGACGAATTGGATGAAGTTAAACGTAAATTTTCTGATAAACGC
    CGTACAGAGTTGATGGTTGGACAGATCTTGAGTCTCGAGGATGAGGACTTGATTGAAGAA
    TCGGATGTCTTGATTACCCTTTCTAACAGAGGCTACATTAAGCGTTTGGATCAGGACGAG
    TTCACTGCTCAAAAACGTGGGGGTCGTGGTGTCCAAGGAACGGGAGTGAAAGATGATGAC
    TTTGTTCGTGAGTTAGTGTCAACTAGCACCCATGATCATCTGCTCTTCTTCACAAACAAG
    GGACGTGTCTATCGTCTTAAAGGTTATGAAATTCCTGAGTATGGTCGGACTGCCAAAGGG
    CTACCAGTAGTCAATCTCTTGAAATTGGATGAAGATGAAAGTATTCAGACGGTTATCAAT
    GTTGAGTCTGATCGCAGTGATGATGCTTATCTCTTCTTTACAACCCGTCACGGTATTGTG
    AAGAGAACTAGTGTTAAGGAGTTTGCCAATATTCGTCAAAATGGTCTCAAAGCGCTGAAT
    TTAAAGGATGAAGATGAGTTAATCAATGTCTTGTTGACAGAAGGAGATATGGATATTATC
    ATTGGTACCAAGTTTGGTTATGCAGTTCGCTTTAATCAATCAGCCGTTCGTGGTATGAGC
    CGTATCGCCACTGGTGTGAAAGGTGTTAACCTTCGTGAAGGAGACACAGTTGTTGGTGCC
    AGCTTGATTACTGATCAAGATGAGGTTCTTATTATCACAGAAAAAGGATATGGTAAGCGT
    ACAGTCGCTACTGAATACCCAACAAAAGGTCGTGGTGGTAAGGGAATGCAGACAGCTAAA
    ATTACCGAAAAAAATGGCTTGCTGGCCGGTCTTATGACTGTTCAAGGGGATGAGGATTTG
    ATGATTATCACTGATACAGGTGTCATGATTCGAACCAATCTTGCCAATATTTCACAAACA
    GGACGTGCAACTATGGGAGTTAAAGTAATGCGCCTGGATCAAGATGCTCAGATAGTGACT
    TTCACAACGGTTGCGGTGGCAGAAAAAGAAGAAGTTGGGACAGAAAACGAAACAGAAGGT
    GAAGCATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2469

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPJ_1134 [new locus tag: SPJ_RS05645 ]
  • symbol: GyrA
  • description: DNA gyrase, A subunit
  • length: 822
  • theoretical pI: 6.07277
  • theoretical MW: 92082.7
  • GRAVY: -0.346229

⊟Function[edit | edit source]

  • reaction:
    EC 5.99.1.3?  ExPASy
    DNA topoisomerase (ATP-hydrolyzing) ATP-dependent breakage, passage and rejoining of double-stranded DNA
  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA gyrase, A subunit (TIGR01063; EC 5.99.1.3; HMM-score: 1186.8)
    and 2 more
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA topoisomerase IV, A subunit (TIGR01061; EC 5.99.1.-; HMM-score: 774.6)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA topoisomerase IV, A subunit (TIGR01062; EC 5.99.1.-; HMM-score: 566.8)
  • TheSEED  :
    • DNA gyrase subunit A (EC 5.99.1.3)
    DNA Metabolism DNA replication DNA topoisomerases, Type II, ATP-dependent  DNA gyrase subunit A (EC 5.99.1.3)
    and 1 more
    Virulence, Disease and Defense Resistance to antibiotics and toxic compounds Resistance to fluoroquinolones  DNA gyrase subunit A (EC 5.99.1.3)
  • PFAM:
    no clan defined DNA_topoisoIV; DNA gyrase/topoisomerase IV, subunit A (PF00521; HMM-score: 528.4)
    and 2 more
    DNA_gyraseA_C; DNA gyrase C-terminal domain, beta-propeller (PF03989; HMM-score: 238.3)
    DUF724; Protein of unknown function (DUF724) (PF05266; HMM-score: 9.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9528
    • Cytoplasmic Membrane Score: 0.0019
    • Cell wall & surface Score: 0.0003
    • Extracellular Score: 0.045
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007511
    • TAT(Tat/SPI): 0.001836
    • LIPO(Sec/SPII): 0.001034
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MQDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVDGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFVIEVKRDASANVILNNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDAEAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPERVSQIIKDELDEVKRKFSDKRRTELMVGQILSLEDEDLIEESDVLITLSNRGYIKRLDQDEFTAQKRGGRGVQGTGVKDDDFVRELVSTSTHDHLLFFTNKGRVYRLKGYEIPEYGRTAKGLPVVNLLKLDEDESIQTVINVESDRSDDAYLFFTTRHGIVKRTSVKEFANIRQNGLKALNLKDEDELINVLLTEGDMDIIIGTKFGYAVRFNQSAVRGMSRIATGVKGVNLREGDTVVGASLITDQDEVLIITEKGYGKRTVATEYPTKGRGGKGMQTAKITEKNGLLAGLMTVQGDEDLMIITDTGVMIRTNLANISQTGRATMGVKVMRLDQDAQIVTFTTVAVAEKEEVGTENETEGEA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=SPJ_1134&oldid=104252"