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SPN994038
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serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae JJA
  • locus tag: SPJ_1261 [new locus tag: SPJ_RS06265 ]
  • pan locus tag?: PNEUPAN002686000
  • symbol: SPJ_1261
  • pan gene symbol?: hom
  • synonym:
  • product: homoserine dehydrogenase (HDH)

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPJ_1261 [new locus tag: SPJ_RS06265 ]
  • symbol: SPJ_1261
  • product: homoserine dehydrogenase (HDH)
  • replicon: chromosome
  • strand: -
  • coordinates: 1207299..1208585
  • length: 1287
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGACAGTTAAAATTGCTTTACTAGGATTTGGTACCGTTGCAAGTGGTGTGCCTTTCCTC
    CTAAAGGAAAATGGAGGAAAAATCAATCAATCAGCACATTCAGATATCAAAGTTGCTAAG
    GTATTGGTCAAGGATGAAGATGAAAAAAATCGCTTGCTTGCAGCAGGGAATGACTTTAAC
    TTTGTAACCAATGTGGATGATATTTTATCAGACCAGGATATTACTATCGTAGTGGAATTG
    ATGGGGCGTATTGAGCCTGCTAAAACCTTTATCACTCGTGCCTTGGAAGCTGGAAAACAC
    GTTGTTACTGCTAACAAGGACCTTTTAGCTGTCCATGGCGCAGAATTGCTAGAAATCGCT
    CAAGCTAACAAGGTAGCACTTTACTACGAAGCAGCAGTTGCTGGTGGGATTCCAATTCTT
    CGTACTTTAGCAAATTCCTTGGCTTCTGATAAAATTACGCGCGTGCTTGGAGTAGTCAAC
    GGAACTTCCAACTTCATGGTGACCAAGATGGTGGAAGAAGGCTGGTCTTACGATGATGCT
    CTTGCGGAAGCACAACGTCTAGGATTTGCAGAAAGCGATCCGACGAATGACGTAGATGGG
    ATTGATGCAGCCTACAAGATGGTTATTTTGAGCCAATTTGCCTTTGGCATGAAGATTGCC
    TTTGATGATGTAGCCCACAAGGGAATCCGCAATATCACACCAGAAGACGTAGCTGTAGCT
    CAAGAGTTTGGTTACGTAGTGAAATTGGTTGGTTCTATTGAGGAAACTTCTTCAGGTATT
    GCTGCAGAAGTGACTCCAACCTTCCTACCTAAAGCGCACCCACTTGCTAGTGTGAATGGC
    GTAATGAACGCTGTCTTTGTAGAATCTATCGGTATTGGTGAGTCTATGTACTACGGACCA
    GGTGCGGGTCAAAAACCAACTGCAACAAGTGTTGTAGCTGATATTGTCCGTATCGTTCGT
    CGTTTGAATGATGGTACCATTGGCAAAGACTTCAACGAATATAGCCGTGACTTGGTCTTG
    GCAAATCCTGAAGATGTCAAAGCAAACTACTATTTCTCAATCTTGGCTCCAGACTCAAAA
    GGTCAGGTCTTGAAGTTGGCTGAAATCTTCAATGCTCAAGATATTTCCTTTAAGCAAATC
    CTTCAAGATGGCAAAGAGGGTGACAAGGCGCGTGTCGTTATCATCACACACAAGATTAAT
    AAAGCCCAGCTTGAAAATGTCTCAGCTGAATTGAAGAAGGTTTCAGAATTCGACCTCTTG
    AATACCTTCAAGGTGCTAGGAGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1287

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPJ_1261 [new locus tag: SPJ_RS06265 ]
  • symbol: SPJ_1261
  • description: homoserine dehydrogenase (HDH)
  • length: 428
  • theoretical pI: 4.79015
  • theoretical MW: 46137.4
  • GRAVY: 0.0621495

⊟Function[edit | edit source]

  • reaction:
    EC 1.1.1.3?  ExPASy
    Homoserine dehydrogenase L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H
  • TIGRFAM:
  • TheSEED  :
    • Homoserine dehydrogenase (EC 1.1.1.3)
    Amino Acids and Derivatives Lysine, threonine, methionine, and cysteine Methionine Biosynthesis  Homoserine dehydrogenase (EC 1.1.1.3)
    and 1 more
    Amino Acids and Derivatives Lysine, threonine, methionine, and cysteine Threonine and Homoserine Biosynthesis  Homoserine dehydrogenase (EC 1.1.1.3)
  • PFAM:
    GADPH_aa-bio_dh (CL0139) Homoserine_dh; Homoserine dehydrogenase (PF00742; HMM-score: 209.7)
    and 3 more
    NADP_Rossmann (CL0063) NAD_binding_3; Homoserine dehydrogenase, NAD binding domain (PF03447; HMM-score: 64.4)
    ACT (CL0070) ACT; ACT domain (PF01842; HMM-score: 24.9)
    NADP_Rossmann (CL0063) GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold (PF01408; HMM-score: 13.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.263331
    • TAT(Tat/SPI): 0.012599
    • LIPO(Sec/SPII): 0.032082
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MTVKIALLGFGTVASGVPFLLKENGGKINQSAHSDIKVAKVLVKDEDEKNRLLAAGNDFNFVTNVDDILSDQDITIVVELMGRIEPAKTFITRALEAGKHVVTANKDLLAVHGAELLEIAQANKVALYYEAAVAGGIPILRTLANSLASDKITRVLGVVNGTSNFMVTKMVEEGWSYDDALAEAQRLGFAESDPTNDVDGIDAAYKMVILSQFAFGMKIAFDDVAHKGIRNITPEDVAVAQEFGYVVKLVGSIEETSSGIAAEVTPTFLPKAHPLASVNGVMNAVFVESIGIGESMYYGPGAGQKPTATSVVADIVRIVRRLNDGTIGKDFNEYSRDLVLANPEDVKANYYFSILAPDSKGQVLKLAEIFNAQDISFKQILQDGKEGDKARVVIITHKINKAQLENVSAELKKVSEFDLLNTFKVLGE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CodY (activation (repression)) regulon
    CodY(TF)important in Amino acid metabolism; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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