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JJA
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serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae JJA
  • locus tag: SPJ_1789 [new locus tag: SPJ_RS08895 ]
  • pan locus tag?: PNEUPAN003377000
  • symbol: treP
  • pan gene symbol?: treP
  • synonym:
  • product: pts system, trehalose-specific iibc component

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPJ_1789 [new locus tag: SPJ_RS08895 ]
  • symbol: treP
  • product: pts system, trehalose-specific iibc component
  • replicon: chromosome
  • strand: -
  • coordinates: 1706054..1708021
  • length: 1968
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    ATGGGAAAATTTGAACAAGAAGCCAAAGATCTGCTTCAGGCAATCGGAGGCAAAGAAAAT
    GTGACTGCCGTAACTCACTGTGCGACACGGATGCGGTTTGTTTTAGGAGATGATAAGAAG
    GCTAATGTTAAAGCTATCGAGTCAATTCCAGCTGTTAAAGGAACCTTTACAAATGCAGGT
    CAATTTCAGGTAATCATTGGAAATGACGTGCCCATCTTTTATAATGATTTTACAGCCGTT
    TCAGGTATTGAGGGTGTTTCCAAAGAAGCAGCCAAGTCTGCAGCTAAGAGTAATCAAAAC
    GTGGTCCAACGTGTTATGACCACTCTGGCGGAGATTTTTACTCCGATTATTCCAGCCTTG
    ATAGTCGGAGGATTGATCCTCGGTTTCCGTAATGTCTTGGAAGGTGTCCATTGGTCGATG
    TTGGATGGCAAGACCATCACAGAATCCTCTCAGTTTTGGGCAGGTGTCAATCACTTCCTC
    TGGTTGCCTGGTGAAGCTATTTTCCAGTTCTTACCAGTAGGGATTACTTGGTCTGTTTCT
    CGTAAGATGGGAACCAGCCAAATTTTGGGAATTGTTCTCGGAATCTGTTTGGTATCGCCT
    CAGTTGCTCAATGCCTATGCGGTTGCTTCAACGCCAGCAGCTGATATCGCGGCAAACTGG
    GTTTGGAATTTTGGCTATTTTACTGTTAATCGTATCGGTTACCAAGCCCAAGTTATCCCA
    GCCTTGCTTGCAGGTTTGAGTCTGTCTTATCTTGAAATCTTCTGGCGCAAGCATATCCCA
    GAAGTCATTTCTATGATTTTTGTACCTTTCTTGTCATTGATTCCAGCCTTGATTTTGGCT
    CATACTGTTTTGGGACCAATCGGTTGGACAATTGGACAAGGACTTTCATCAGTTGTCTTG
    GCAGGTTTAACTGGTCCAGTTAAATGGCTCTTCGGTGCAATTTTTGGCGCCCTCTACGCT
    CCATTTGTCATCACAGGTCTGCACCATATGACCAATGCCATTGATACACAATTGATTGCG
    GATGCTGGTGGCACTGCCCTATGGCCAATGATTGCTCTTTCTAATATTGCTCAAGGCTCA
    GCCGTGTTTGCCTATTATTTCATGCATCGCCATGATGAGCGTGAGGCTCAGGTTTCACTT
    CCTGCAACCATTTCAGCCTATCTCGGTGTTACAGAACCAGCTCTTTTTGGGGTTAACGTA
    AAATATATTTATCCATTTGTTGCTGGGATGACTGGTTCAGCCCTTGCAGGCATGTTATCC
    GTTACTTTTAATGTAACTGCGGCTTCTATTGGTATCGGTGGTTTGCCAGGTATTCTCTCT
    ATTCAACCTCAATACATGCTGCCATTTGCAGGAACTATGCTAGTTGCGATTGTTGTTCCA
    ATGCTCTTGACTTTCTTCTTCCGCAAGGCTGGTCTCTTTACAAAAACAGAGGGCGATACG
    AACTTGCAGGCAGAATTCGTTGCTCAAGAAGAAGCAGAATTTGTGAACCATGAACCAGTA
    GAACTTACTTCGGTAGAAATTATCAGCCCACTAACTGGCCAAGTGAAAGAATTGAGTCAA
    GCGACGGATCCTATTTTTGCATCAGGTGTCATGGGGCAAGGTCTAGTCATTGAACCAAGC
    CAAGGTGAGTTGACCTCTCCAGTTAATGGAACAGTGACGGTTCTTTTCCCTACCAAGCAT
    GCCATCGGCATTGTCTCTGACGAGGGAGTTGAATTGCTCATCCACATCGGTATGGATACA
    GTAGGTCTTGATGGCAAAGGTTTTGAAAGTCTTGTAGTCCAAGGAGATCACGTTACAGTT
    GGTCAGCAACTGATTCGTTTTGATATGGATGTCATTAAGGCTGCAGGTCTGGTGACAGAA
    ACTCCTGTTATCATCACCAACCAAGATGCTTATACAGCGACTATTACTGGAACTTATCCG
    ACAACGATCCAAGCTGGAGCATCTCTCATGGTCGCTACACGAATCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1968

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPJ_1789 [new locus tag: SPJ_RS08895 ]
  • symbol: TreP
  • description: pts system, trehalose-specific iibc component
  • length: 655
  • theoretical pI: 5.14274
  • theoretical MW: 69906.7
  • GRAVY: 0.495573

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.1.69?  ExPASy
    Transferred entry: 2.7.1.191, 2.7.1.192, 2.7.1.193, 2.7.1.194, 2.7.1.195, 2.7.1.196, 2.7.1.197, 2.7.1.198, 2.7.1.199, 2.7.1.200, 2.7.1.201, 2.7.1.202, 2.7.1.203, 2.7.1.204, 2.7.1.205, 2.7.1.206, 2.7.1.207 and 2.7.1.208
  • TIGRFAM:
    PTS system, trehalose-specific IIBC component (TIGR01992; EC 2.7.1.69; HMM-score: 729)
    and 12 more
    PTS system, beta-glucoside-specific IIABC component (TIGR01995; EC 2.7.1.69; HMM-score: 487.8)
    PTS system, sucrose-specific IIBC component (TIGR01996; EC 2.7.1.69; HMM-score: 436.3)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, maltose and glucose-specific subfamily, IIC component (TIGR00852; HMM-score: 215.8)
    Signal transduction Signal transduction PTS PTS system, maltose and glucose-specific subfamily, IIC component (TIGR00852; HMM-score: 215.8)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, glucose subfamily, IIA component (TIGR00830; HMM-score: 136.8)
    Signal transduction Signal transduction PTS PTS system, glucose subfamily, IIA component (TIGR00830; HMM-score: 136.8)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, glucose-like IIB component (TIGR00826; EC 2.7.1.69; HMM-score: 66.3)
    Signal transduction Signal transduction PTS PTS system, glucose-like IIB component (TIGR00826; EC 2.7.1.69; HMM-score: 66.3)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, alpha-glucoside-specific IIBC component (TIGR02005; EC 2.7.1.69; HMM-score: 37.6)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, N-acetylglucosamine-specific IIBC component (TIGR01998; EC 2.7.1.69; HMM-score: 37.2)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, maltose and glucose-specific IIBC component (TIGR02004; EC 2.7.1.69; HMM-score: 36.3)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, glucose-specific IIBC component (TIGR02002; EC 2.7.1.69; HMM-score: 21)
  • TheSEED  :
    • PTS system, trehalose-specific IIA component (EC 2.7.1.69)
    • PTS system, trehalose-specific IIB component (EC 2.7.1.69)
    • PTS system, trehalose-specific IIC component (EC 2.7.1.69)
    Carbohydrates Di- and oligosaccharides Trehalose Uptake and Utilization  PTS system, trehalose-specific IIA component (EC 2.7.1.69)
    and 2 more
    Carbohydrates Di- and oligosaccharides Trehalose Uptake and Utilization  PTS system, trehalose-specific IIB component (EC 2.7.1.69)
    Carbohydrates Di- and oligosaccharides Trehalose Uptake and Utilization  PTS system, trehalose-specific IIC component (EC 2.7.1.69)
  • PFAM:
    Hybrid (CL0105) PTS_EIIA_1; phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 (PF00358; HMM-score: 161.3)
    and 3 more
    PTS_EIIC (CL0493) PTS_EIIC; Phosphotransferase system, EIIC (PF02378; HMM-score: 128)
    no clan defined PTS_EIIB; phosphotransferase system, EIIB (PF00367; HMM-score: 52)
    Hybrid (CL0105) RnfC_N; RnfC Barrel sandwich hybrid domain (PF13375; HMM-score: 12.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 10
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.0262
    • TAT(Tat/SPI): 0.006201
    • LIPO(Sec/SPII): 0.002297
  • predicted transmembrane helices (TMHMM): 10

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MGKFEQEAKDLLQAIGGKENVTAVTHCATRMRFVLGDDKKANVKAIESIPAVKGTFTNAGQFQVIIGNDVPIFYNDFTAVSGIEGVSKEAAKSAAKSNQNVVQRVMTTLAEIFTPIIPALIVGGLILGFRNVLEGVHWSMLDGKTITESSQFWAGVNHFLWLPGEAIFQFLPVGITWSVSRKMGTSQILGIVLGICLVSPQLLNAYAVASTPAADIAANWVWNFGYFTVNRIGYQAQVIPALLAGLSLSYLEIFWRKHIPEVISMIFVPFLSLIPALILAHTVLGPIGWTIGQGLSSVVLAGLTGPVKWLFGAIFGALYAPFVITGLHHMTNAIDTQLIADAGGTALWPMIALSNIAQGSAVFAYYFMHRHDEREAQVSLPATISAYLGVTEPALFGVNVKYIYPFVAGMTGSALAGMLSVTFNVTAASIGIGGLPGILSIQPQYMLPFAGTMLVAIVVPMLLTFFFRKAGLFTKTEGDTNLQAEFVAQEEAEFVNHEPVELTSVEIISPLTGQVKELSQATDPIFASGVMGQGLVIEPSQGELTSPVNGTVTVLFPTKHAIGIVSDEGVELLIHIGMDTVGLDGKGFESLVVQGDHVTVGQQLIRFDMDVIKAAGLVTETPVIITNQDAYTATITGTYPTTIQAGASLMVATRI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: CcpA regulon, TreR (repression) regulon
    CcpA(TF)important in Global catabolite repression; RegPrecise 
    TreR(TF)important in Trehalose utilization; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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