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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN032672
  • locus tag: SPN032672_RS02655
  • pan locus tag?: PNEUPAN002968000
  • symbol: SPN032672_RS02655
  • pan gene symbol?: cshA
  • synonym:
  • product: DEAD/DEAH box helicase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN032672_RS02655
  • symbol: SPN032672_RS02655
  • product: DEAD/DEAH box helicase
  • replicon: chromosome
  • strand: -
  • coordinates: 507780..509354
  • length: 1575
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_021003 (507780..509354) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1413 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    GTGAAATTTAATGAATTAAACTTGTCTGCTGATTTGCTAGCAGAAATTGAAAAAGCTGGT
    TTTGTAGAAGCTAGTCCTATCCAAGAACAAACTATTCCTTTGGCCCTTGAAGGCAAGGAT
    GTTATCGGTCAAGCTCAGACTGGTACAGGAAAAACTGCAGCCTTTGGCTTGCCTACCCTT
    GAAAAAATCCGTACAGAAGAAGCGACTATCCAAGCTTTGGTCATCGCTCCAACTCGTGAA
    CTAGCTGTCCAAAGTCAAGAAGAACTCTTCCGCTTTGGTCGTAGTAAGGGAGTCAAAGTC
    CGTTCAGTATATGGCGGATCAAGCATTGAAAAACAAATTAAGGCTCTTAAATCTGGTGCC
    CATATCGTGGTGGGAACTCCAGGTCGCCTCTTGGACTTGATTAAACGCAAGGCCTTGAAA
    TTACAAGACATTGAAACCCTTATCCTTGACGAAGCGGATGAAATGCTTAACATGGGCTTC
    CTTGAAGACATCGAAGCCATTATTTCCCGTGTACCTGAGAACCGTCAAACTTTGCTTTTC
    TCAGCAACTATGCCAGATGCCATCAAACGTATCGGTGTTCAGTTTATGAAAGCCCCTGAA
    CATGTCAAGATTGCGGCTAAGGAATTGACAACAGAATTGGTTGACCAGTACTATATCCGT
    GTTAAGGAACAAGAAAAATTTGACACCATGACTCGTCTCATGGATGTGGCACAACCAGAA
    CTCGCTATTGTATTTGGTCGTACCAAACGCCGTGTGGATGAATTGACTCGTGGTTTGAAA
    ATTCGTGGCTTCCGTGCAGAAGGAATTCATGGCGACCTAGACCAAAACAAACGTCTTCGT
    GTCCTTCGTGACTTTAAAAATGGCAATCTTGATGTTTTGGTTGCGACAGACGTTGCAGCG
    CGTGGTTTGGATATTTCAGGTGTGACCCATGTCTACAACTACGATATTCCACAAGATCCT
    GAGAGTTATGTTCACCGTATCGGTCGTACAGGTCGTGCTGGTAAGTCAGGTCAATCTATT
    ACTTTTGTTGCTCCAAACGAAATGGGTTACCTTCAAATCATTGAAAACTTGACTAAGAAA
    CGCATGAAAGGTCTCAAACCTGCAAGTGTAGAAGAATCCTTCCAATCAAAAAAACAGGTA
    GCTCTCAAGAAAATCGAACGTGATTTTGCAGATGAAACCATTCGTGCCAACTTTGAGAAA
    TTTGGTAAGGATGCTCGCAAATTGGCTGCTGAGTTTACTCCAGAAGAATTGGCAATGTAT
    ATCTTGAGTCTGACAGTCCAAGACCCAGATAGCCTTCCAGAAGTGGAGATTGCACGTGAA
    AAACCACTACCGTTTAAACCATCAGGTAATGGTTTCGGTGGTAAAGCTAAGGGAGGTCGT
    GGAGGCCGTCGTGGGGACGACCGTCGAGAGCGTGATCGCCGTGGCAATGGTCGCCGTGAT
    GAGTTCAAAAAAGGAAGTCGTGGCAACGATCGTTTTGATAAGGAAAAACGTTACCGTAAG
    GATAATAAAAAACCACGCAATACTTTAAGCGAAAAGCAAACAGGCTTTGTTATTCGTAAC
    AAAGGCGATAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1575

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN032672_RS02655
  • symbol: SPN032672_RS02655
  • description: DEAD/DEAH box helicase
  • length: 524
  • theoretical pI: 10.2388
  • theoretical MW: 58827
  • GRAVY: -0.597901

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair ATP-dependent DNA helicase RecQ (TIGR01389; EC 3.6.4.12; HMM-score: 82.7)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair ATP-dependent DNA helicase, RecQ family (TIGR00614; EC 3.6.4.12; HMM-score: 72.7)
    DEXH box helicase, DNA ligase-associated (TIGR04121; EC 3.6.4.-; HMM-score: 66.8)
    and 8 more
    helicase/secretion neighborhood putative DEAH-box helicase (TIGR03817; HMM-score: 49)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair excinuclease ABC subunit B (TIGR00631; EC 3.1.25.-; HMM-score: 38)
    DNA phosphorothioation system restriction enzyme (TIGR04095; HMM-score: 37.1)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair ATP-dependent DNA helicase RecG (TIGR00643; EC 3.6.4.12; HMM-score: 34.5)
    CRISPR-associated helicase Cas3 (TIGR01587; HMM-score: 28.1)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair transcription-repair coupling factor (TIGR00580; EC 3.6.1.-; HMM-score: 20.5)
    Unknown function Enzymes of unknown specificity ATP-dependent helicase HrpB (TIGR01970; EC 3.6.4.-; HMM-score: 18.9)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair primosomal protein N' (TIGR00595; EC 3.6.1.-; HMM-score: 16.6)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    P-loop_NTPase (CL0023) DEAD; DEAD/DEAH box helicase (PF00270; HMM-score: 176.7)
    and 7 more
    Helicase_C; Helicase conserved C-terminal domain (PF00271; HMM-score: 110.6)
    ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 28.3)
    CMS1; U3-containing 90S pre-ribosomal complex subunit (PF14617; HMM-score: 19.1)
    Helicase_RecD; Helicase (PF05127; HMM-score: 17.1)
    AAA_30; AAA domain (PF13604; HMM-score: 17.1)
    no clan defined DUF6363; Domain of unknown function (DUF6363) (PF19890; HMM-score: 11.8)
    P-loop_NTPase (CL0023) AAA_22; AAA domain (PF13401; HMM-score: 11.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 10
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.009073
    • TAT(Tat/SPI): 0.00156
    • LIPO(Sec/SPII): 0.000933
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000671113 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKFNELNLSADLLAEIEKAGFVEASPIQEQTIPLALEGKDVIGQAQTGTGKTAAFGLPTLEKIRTEEATIQALVIAPTRELAVQSQEELFRFGRSKGVKVRSVYGGSSIEKQIKALKSGAHIVVGTPGRLLDLIKRKALKLQDIETLILDEADEMLNMGFLEDIEAIISRVPENRQTLLFSATMPDAIKRIGVQFMKAPEHVKIAAKELTTELVDQYYIRVKEQEKFDTMTRLMDVAQPELAIVFGRTKRRVDELTRGLKIRGFRAEGIHGDLDQNKRLRVLRDFKNGNLDVLVATDVAARGLDISGVTHVYNYDIPQDPESYVHRIGRTGRAGKSGQSITFVAPNEMGYLQIIENLTKKRMKGLKPASVEESFQSKKQVALKKIERDFADETIRANFEKFGKDARKLAAEFTPEELAMYILSLTVQDPDSLPEVEIAREKPLPFKPSGNGFGGKAKGGRGGRRGDDRRERDRRGNGRRDEFKKGSRGNDRFDKEKRYRKDNKKPRNTLSEKQTGFVIRNKGDK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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