PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 26-AUG-2017

⊟Summary

• organism: Streptococcus pneumoniae SPN034156
• locus tag: SPN034156_04720 [new locus tag: SPN034156_RS02540 ]
• pan locus tag^?: PNEUPAN002959000
• symbol: SPN034156_04720
• pan gene symbol^?: dnaD
• synonym:
• product: putative DNA replication protein DnaD

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPN034156_04720 [new locus tag: SPN034156_RS02540 ]
• symbol: SPN034156_04720
• product: putative DNA replication protein DnaD
• replicon: chromosome
• strand: -
• coordinates: 483407..484084
• length: 678
• essential: unknown other strains

⊟Accession numbers

• Location: FQ312045 (483407..484084) NCBI
• BioCyc:
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1405 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
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  481
  541
  601
  661
  
  ATGACATATTTAGACGCTTTTAAATCAGGTACCTTGGTTTTACCGAGTGCCCTGCTCTTG
  CATTTTAAGGAACTCTTTCCTTCTAGCGACGATTTTCTGGTTTGGCAATTTTTCTATTTG
  CAAAATACGACAGGCTTAGAAGAAATGTCGCCAAGCCAGATTGCTGAAAGGATTGGCAAG
  GAAATTTCGGATGTCAACCAGTCCATTTCTAATCTGACGGAAAGGGGACTGCTCCAGTAT
  CGTACTATCGAATTAAATGGCGAAATTGAATTGCTCTTTGATGCTAGTTTGGCCTTGGAA
  CGTTTGGATGACCTGTTTGGAGCAGTTCATTCAAGTTCAGACCAGCTAACACCTCAAAAC
  CAGCTCAAGGATTTGGTGGAAACCTTCCAGCAGGAGTTGGGACGATTGTTGACGCCTTTT
  GAGATTGAGGATTTGACCAAGACACTAAAGGAAGATGGAACCAGTGCTGACTTGATTAAG
  GAGGCTCTTCGTGAAGCTGTTTTGAATGGAAAACCAAACTGGAAGTACATTCAGGCGATT
  TTGAGAAACTGGCGCCATGAAGGAATCAAGAGTGTGGCTCAAATTGAGGCCAAGAGAGCA
  GAAAGAGAAGCAAGCAATCCTCAGTTGACACAGGTATCTGCAGATTTCAGAAATGCCATG
  GATCTCTGGAAGGATTAA
  60
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  540
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  678
  

⊟Protein

⊟General

• locus tag: SPN034156_04720 [new locus tag: SPN034156_RS02540 ]
• symbol: SPN034156_04720
• description: putative DNA replication protein DnaD
• length: 225
• theoretical pI: 4.44271
• theoretical MW: 25648.8
• GRAVY: -0.357778

⊟Function

• TIGRFAM:
  Genetic information processing DNA metabolism DNA replication, recombination, and repair DnaD domain protein (TIGR01446; HMM-score: 97.9)
  Genetic information processing Mobile and extrachromosomal element functions Prophage functions DnaD domain protein (TIGR01446; HMM-score: 97.9)
  and 1 more
  Genetic information processing DNA metabolism DNA replication, recombination, and repair DnaD family protein (TIGR04548; HMM-score: 16.5)
• TheSEED  :
  • Chromosome replication initiation protein DnaD
• PFAM:
  no clan defined DnaB_2; Replication initiation and membrane attachment (PF07261; HMM-score: 82.7)
  and 8 more
  HTH (CL0123) MarR_2; MarR family (PF12802; HMM-score: 18.5)
  HTH_Crp_2; Crp-like helix-turn-helix domain (PF13545; HMM-score: 16.6)
  Fe_dep_repress; Iron dependent repressor, N-terminal DNA binding domain (PF01325; HMM-score: 16.2)
  HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 16.2)
  TrmB; Sugar-specific transcriptional regulator TrmB (PF01978; HMM-score: 14.1)
  no clan defined CtsR_C; CtsR C-terminal dimerization domain (PF17727; HMM-score: 13.6)
  HTH (CL0123) HTH_IclR; IclR helix-turn-helix domain (PF09339; HMM-score: 13)
  no clan defined VPS11_C; Vacuolar protein sorting protein 11 C terminal (PF12451; HMM-score: 12.5)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.011088
  • TAT(Tat/SPI): 0.001103
  • LIPO(Sec/SPII): 0.001374
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: CCP36141 NCBI
• UniProt:

⊟Protein sequence

• MTYLDAFKSGTLVLPSALLLHFKELFPSSDDFLVWQFFYLQNTTGLEEMSPSQIAERIGKEISDVNQSISNLTERGLLQYRTIELNGEIELLFDASLALERLDDLFGAVHSSSDQLTPQNQLKDLVETFQQELGRLLTPFEIEDLTKTLKEDGTSADLIKEALREAVLNGKPNWKYIQAILRNWRHEGIKSVAQIEAKRAEREASNPQLTQVSADFRNAMDLWKD

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_1405 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications