PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 26-AUG-2017

⊟Summary

• organism: Streptococcus pneumoniae SPN034156
• locus tag: SPN034156_12050 [new locus tag: SPN034156_RS06770 ]
• pan locus tag^?: PNEUPAN000761000
• symbol: SPN034156_12050
• pan gene symbol^?: apbA
• synonym:
• product: putative extracellular amino acid-binding protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPN034156_12050 [new locus tag: SPN034156_RS06770 ]
• symbol: SPN034156_12050
• product: putative extracellular amino acid-binding protein
• replicon: chromosome
• strand: +
• coordinates: 1247615..1248523
• length: 909
• essential: unknown

⊟Accession numbers

• Location: FQ312045 (1247615..1248523) NCBI
• BioCyc:
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0109 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  
  TTGTTTCAAATTGAAAATTTTTTCAATTTAGGCTTGACAAAGGATGAGTATAGGAGTATT
  ATTTATACAATAAAAAAGAATAAACATAAAGAAGGCTTTGTTATGAATAAGATGAAGAAG
  GTGTTGATGACGATGTTTGGTTTAGTGATGCTCCCCCTACTATTTGCTTGTAGTAACAAT
  CAATCGGCTGGAATTGAAGCCATCAAGTCCAAAGGAAAATTGGTTGTAGCCCTCAATCCA
  GATTTTGCTCCATTTGAATATCAAAAAGTGGTTGATGGGAAAAATCAGATTGTGGGTTCA
  GATATCGAATTAGCCAAGGCTATCGCAACAGAACTAGGTGTCGAATTGGAACTATCTCCT
  ATGAGTTTTGACAATGTACTGGCTAGCGTTCAATCAGGAAAAGCTGACCTTGCCATATCA
  GGTGTTTCTAAGACAGATGAACGGAGCAAGGTGTTTGATTTTTCAACTCCCTACTATACT
  GCAAAAAATAAACTCATTGTCAAAAAATCTGATTTAGCCACTTATCAGTCTGTCAACGAT
  TTGGCGCAGAAAAAGGTCGGAGCGCAGAAAGGTTCGATTCAAGAGACGATGGCGAAAGAT
  TTGCTACAAAATTCTTCCCTCGTATCTCTGCCTAAAAATGGGAATTTAATCACAGATTTA
  AAATCAGGGCAAGTGGATGCCGTTATTTTTGAAGAACCCGTTGCCAAGGGATTTGTGGAA
  AATAATCCTGATTTAGCAATCGCAGACCTCAATTTTGAAAAAGAGCAAGATGATTCCTAC
  GCGGTAGCCATGAAAAAAGATAGCAAGGAATTGAAAGAGGCAGTCGATAAAACCATTCAA
  AAGTTGAAGGAGTCTGGGGAATTAGACAAACTCATTGAGGATGCCTTTAAAGCATCCATT
  GAAAAATAG
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  909
  

⊟Protein

⊟General

• locus tag: SPN034156_12050 [new locus tag: SPN034156_RS06770 ]
• symbol: SPN034156_12050
• description: putative extracellular amino acid-binding protein
• length: 302
• theoretical pI: 5.59278
• theoretical MW: 33343.2
• GRAVY: -0.254305

⊟Function

• TIGRFAM:
  Metabolism Transport and binding proteins Amino acids, peptides and amines lysine-arginine-ornithine-binding periplasmic protein (TIGR01096; HMM-score: 153.7)
  and 4 more
  Metabolism Transport and binding proteins Amino acids, peptides and amines ectoine/hydroxyectoine ABC transporter solute-binding protein EhuB (TIGR02995; HMM-score: 74.3)
  extracellular substrate-binding orphan protein, GRRM family (TIGR04262; HMM-score: 45.3)
  quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein (TIGR03871; HMM-score: 39.4)
  Metabolism Transport and binding proteins Other ABC transporter, substrate-binding protein, aliphatic sulfonates family (TIGR01728; HMM-score: 24)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  PBP (CL0177) SBP_bac_3; Bacterial extracellular solute-binding proteins, family 3 (PF00497; HMM-score: 203.9)
  and 4 more
  Lig_chan-Glu_bd; Ligated ion channel L-glutamate- and glycine-binding site (PF10613; HMM-score: 31.7)
  NMT1; NMT1/THI5 like (PF09084; HMM-score: 25.7)
  no clan defined PMC2NT; PMC2NT (NUC016) domain (PF08066; HMM-score: 15.4)
  PBP (CL0177) LysR_substrate; LysR substrate binding domain (PF03466; HMM-score: 12.5)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic Membrane
  • Cytoplasmic Score: 0
  • Cytoplasmic Membrane Score: 0.9477
  • Cell wall & surface Score: 0.0025
  • Extracellular Score: 0.0498
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.052252
  • TAT(Tat/SPI): 0.015098
  • LIPO(Sec/SPII): 0.416253
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: CCP36874 NCBI
• UniProt:

⊟Protein sequence

• MFQIENFFNLGLTKDEYRSIIYTIKKNKHKEGFVMNKMKKVLMTMFGLVMLPLLFACSNNQSAGIEAIKSKGKLVVALNPDFAPFEYQKVVDGKNQIVGSDIELAKAIATELGVELELSPMSFDNVLASVQSGKADLAISGVSKTDERSKVFDFSTPYYTAKNKLIVKKSDLATYQSVNDLAQKKVGAQKGSIQETMAKDLLQNSSLVSLPKNGNLITDLKSGQVDAVIFEEPVAKGFVENNPDLAIADLNFEKEQDDSYAVAMKKDSKELKEAVDKTIQKLKESGELDKLIEDAFKASIEK

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for D39V, TIGR4

⊟Expression data

• PneumoExpress for strain D39V: SPV_0109 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications