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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 10-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN034156
  • locus tag: SPN034156_RS01910 [old locus tag: SPN034156_03590 ]
  • pan locus tag?: PNEUPAN000198000
  • symbol: guaA
  • pan gene symbol?: guaA
  • synonym:
  • product: glutamine-hydrolyzing GMP synthase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN034156_RS01910 [old locus tag: SPN034156_03590 ]
  • symbol: guaA
  • product: glutamine-hydrolyzing GMP synthase
  • replicon: chromosome
  • strand: -
  • coordinates: 370220..371782
  • length: 1563
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_021006 (370220..371782) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1274 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    ATGAGCAACATTTCAACTGATTTGCAAGATGTAGAAAAAATCATCGTATTGGACTATGGT
    AGCCAGTACAACCAGCTGATTTCACGCCGTATCCGTGAGATTGGTGTTTTTTCAGAACTA
    AAAAGCCATAAAATTTCAGCTGCTGAAGTTCGTGAAGTCAATCCTGTAGGAATTATTCTA
    TCAGGTGGTCCAAATTCTGTATATGAAGATGGTTCATTTGACATTGACCCAGAAATCTTC
    GAACTAGGAATTCCAATTTTGGGAATCTGTTATGGTATGCAGTTATTGACCCATAAACTT
    GGAGGAAAAGTTGTTCCTGCAGGTGATGCTGGAAATCGTGAATACGGTCAATCAACCCTA
    ACTCACACACCATCAGCGCTTTTTGAATCAACACCTGATGAACAGACTGTTTTGATGAGC
    CATGGTGATGCGGTTACTGAGATTCCTGCTGACTTTGTTCGTACAGGTACATCAGCTGAC
    TGCCCATACGCAGCCATCGAAAACCCAGATAAACACATTTACGGTATCCAATTCCACCCA
    GAAGTTCGTCATTCTGTATACGGAAATGATATCCTTCGTAACTTTGCCCTTAACATTTGT
    AAGGCTAAAGGTGACTGGTCAATGGATAATTTCATTGACATGCAGATCAAAAAAATTCGT
    GAAACCGTCGGTGATAAACGTGTCCTTCTTGGTCTATCAGGTGGTGTTGACTCATCTGTC
    GTTGGGGTTCTTCTCCAAAAAGCGATTGGCGATCAATTGATCTGTATCTTCGTAGACCAC
    GGTCTTCTTCGTAAAGGCGAAGCTGATCAAGTTATGGACATGCTCGGTGGTAAGTTTGGT
    TTGAATATCGTCAAAGCAGACGCTGCTAAACGTTTCCTTGACAAACTTGCTGGCGTTTCT
    GACCCTGAACAAAAACGTAAAATCATCGGTAACGAGTTTGTCTATGTATTCGATGACGAA
    GCAAGCAAGCTCAAAGATGTGAAATTCCTTGCTCAAGGTACTTTATATACAGATGTTATC
    GAGTCTGGTACGGATACAGCTCAAACTATCAAGTCACACCACAACGTGGGTGGTCTTCCA
    GAAGATATGCAGTTTGAATTGATTGAACCACTCAATACTCTTTACAAGGATGAAGTTCGT
    GCTCTTGGTACAGAGCTTGGTATGCCAGACCATATCGTATGGCGCCAACCATTCCCAGGA
    CCAGGACTTGCTATCCGTGTCATGGGTGAAATCACTGAAGAGAAACTTGAAACCGTTCGT
    GAATCAGACGCTATTCTTCGTGAAGAAATCGCTAAAGCTGGACTTGACCGCGATATTTGG
    CAATACTTCACTGTTAACACAGGCGTTCGTTCAGTCGGCGTTATGGGTGACGGTCGTACG
    TATGACTACACGATTGCAATCCGTGCTATCACTTCTATCGATGGTATGACTGCTGATTTT
    GCCAAAATTCCATGGGAAGTACTTCAAAAAATCTCAGTACGTATCGTAAATGAAGTGGAT
    CATGTTAACCGTATCGTCTACGATATTACAAGTAAACCACCTGCAACAGTTGAGTGGGAA
    TAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1563

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN034156_RS01910 [old locus tag: SPN034156_03590 ]
  • symbol: GuaA
  • description: glutamine-hydrolyzing GMP synthase
  • length: 520
  • theoretical pI: 4.69444
  • theoretical MW: 57472
  • GRAVY: -0.159808

⊟Function[edit | edit source]

  • reaction:
    EC 6.3.5.2?  ExPASy
    GMP synthase (glutamine-hydrolyzing) ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis GMP synthase (glutamine-hydrolyzing), C-terminal domain (TIGR00884; EC 6.3.5.2; HMM-score: 506.5)
    and 14 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis GMP synthase (glutamine-hydrolyzing), N-terminal domain (TIGR00888; EC 6.3.5.2; HMM-score: 232.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridine nucleotides NAD+ synthetase (TIGR00552; EC 6.3.1.5; HMM-score: 44.6)
    glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase (TIGR00566; HMM-score: 44.3)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis carbamoyl-phosphate synthase, small subunit (TIGR01368; EC 6.3.5.5; HMM-score: 44)
    Metabolism Amino acid biosynthesis Aromatic amino acid family anthranilate synthase (TIGR01815; EC 4.1.3.27; HMM-score: 42.8)
    Metabolism Amino acid biosynthesis Histidine family imidazole glycerol phosphate synthase, glutamine amidotransferase subunit (TIGR01855; EC 2.4.2.-; HMM-score: 31.5)
    Hypothetical proteins Conserved TIGR00268 family protein (TIGR00268; HMM-score: 22)
    aminodeoxychorismate synthase (TIGR01823; EC 2.6.1.85; HMM-score: 20.7)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (TIGR00420; EC 2.1.1.61; HMM-score: 17.4)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA(Ile)-lysidine synthetase (TIGR02432; EC 6.3.4.-; HMM-score: 16.2)
    Metabolism Amino acid biosynthesis Aspartate family asparagine synthase (glutamine-hydrolyzing) (TIGR01536; EC 6.3.5.4; HMM-score: 15.3)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis CTP synthase (TIGR00337; EC 6.3.4.2; HMM-score: 13.5)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis phosphoribosylformylglycinamidine synthase I (TIGR01737; EC 6.3.5.3; HMM-score: 13.1)
    asparagine synthase family amidotransferase (TIGR03104; HMM-score: 11.9)
  • TheSEED: see SPN034156_03590
  • PFAM:
    no clan defined GMP_synt_C; GMP synthase C terminal domain (PF00958; HMM-score: 147.8)
    Glutaminase_I (CL0014) GATase; Glutamine amidotransferase class-I (PF00117; HMM-score: 139)
    and 7 more
    HUP (CL0039) NAD_synthase; NAD synthase (PF02540; HMM-score: 46)
    Glutaminase_I (CL0014) Peptidase_C26; Peptidase C26 (PF07722; HMM-score: 45)
    HUP (CL0039) tRNA_Me_trans; tRNA methyl transferase HUP domain (PF03054; HMM-score: 19.1)
    Asn_synthase; Asparagine synthase (PF00733; HMM-score: 17.6)
    ATP_bind_3; PP-loop family (PF01171; HMM-score: 17.5)
    QueC; Queuosine biosynthesis protein QueC (PF06508; HMM-score: 16.7)
    Glutaminase_I (CL0014) GATase_5; CobB/CobQ-like glutamine amidotransferase domain (PF13507; HMM-score: 15.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003026
    • TAT(Tat/SPI): 0.001049
    • LIPO(Sec/SPII): 0.000284
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000065723 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSNISTDLQDVEKIIVLDYGSQYNQLISRRIREIGVFSELKSHKISAAEVREVNPVGIILSGGPNSVYEDGSFDIDPEIFELGIPILGICYGMQLLTHKLGGKVVPAGDAGNREYGQSTLTHTPSALFESTPDEQTVLMSHGDAVTEIPADFVRTGTSADCPYAAIENPDKHIYGIQFHPEVRHSVYGNDILRNFALNICKAKGDWSMDNFIDMQIKKIRETVGDKRVLLGLSGGVDSSVVGVLLQKAIGDQLICIFVDHGLLRKGEADQVMDMLGGKFGLNIVKADAAKRFLDKLAGVSDPEQKRKIIGNEFVYVFDDEASKLKDVKFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMQFELIEPLNTLYKDEVRALGTELGMPDHIVWRQPFPGPGLAIRVMGEITEEKLETVRESDAILREEIAKAGLDRDIWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADFAKIPWEVLQKISVRIVNEVDHVNRIVYDITSKPPATVEWE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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