PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 10-APR-2025

⊟Summary

• organism: Streptococcus pneumoniae SPN034156
• locus tag: SPN034156_RS08305 [old locus tag: SPN034156_14950 ]
• pan locus tag^?: PNEUPAN001306000
• symbol: dinB
• pan gene symbol^?: dinP
• synonym:
• product: DNA polymerase IV

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPN034156_RS08305 [old locus tag: SPN034156_14950 ]
• symbol: dinB
• product: DNA polymerase IV
• replicon: chromosome
• strand: -
• coordinates: 1536354..1537415
• length: 1062
• essential: unknown

⊟Accession numbers

• Location: NC_021006 (1536354..1537415) NCBI
• BioCyc:
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0419 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  
  ATGTTGATTTTTCCTTTGTTAAATGATTTGTCAAGAAAAATCATCCATATTGACATGGAT
  GCCTTTTTTGCTGCAGTGGAAATCAGGGATAATCCTAAACTCAGAGGAAAACCTGTCATT
  ATTGGAAGCGACCCTCGGCAAACAGGTGGACGGGGAGTCGTTTCTACCTGTAGTTATGAG
  GCAAGAGCTTTTGGTGTCCATTCTGCCATGAGTTCCAAGGAAGCTTATGAACGTTGTCCC
  CAGGCCGTCTTTATCTCAGGAAATTATGAGAAATACAAAGCTGTGGGACTCCAGATTCGA
  GCTATTTTTAAGCGCTATACAGATTTGATTGAACCCATGAGCATTGACGAAGCCTATTTG
  GATGTGACAGAAAATAAACTCGGTATCAAGTCAGCGGTCAAAATTGCTCGCCTCATTCAA
  AAAGATATCTGGCAAGAACTCCATCTAACTGCTTCTGCCGGTATTTCCTATAACAAGTTC
  TTAGCTAAAATGGCGAGTGATTATCAAAAACCTCATGGTTTGACAGTGATTCTACCTGAA
  CAGGCTGAGGATTTTCTCAAACAAATGAATATTTCCAAATTTCATGGAGTAGGAAAAAAG
  ACAGTAGAACGTCTTCATCAAATGGGCGTTTTTACTGGTGCTGATTTACTTGAAGTTCCT
  GAGGTAACCCTAATAGACCGTTTTGGTAGACTAGGCTATGATCTGTATCGAAAGGCTCGT
  GGCATTCACAACTCTCCAGTCAAATCCAATCGCATCCGTAAATCAATCGGCAAGGAGAAA
  ACCTACGGGAAGATTCTCCGTGCCGAGGAAGATATCAAAAAAGAGCTGACTCTTCTATCA
  GAAAAAGTCGCTCTCAATCTACATCAACAAGAAAAAGCTGGAAAAATTGTCATTTTGAAA
  ATCCGCTACGAGGACTTTTCAACTCTTACCAAACGAAAAAGTCTTGCTCAAAAAACACAA
  GATGCTAGTCAGATAAGCCAAATAGCCCTGCAACTCTATGAAGAATTAAGCGAGAAAGAA
  AGAGGTGTCCGCCTATTGGGGATTACCATGACTGGATTTTAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1062
  

⊟Protein

⊟General

• locus tag: SPN034156_RS08305 [old locus tag: SPN034156_14950 ]
• symbol: DinB
• description: DNA polymerase IV
• length: 353
• theoretical pI: 10.0361
• theoretical MW: 39921.1
• GRAVY: -0.298017

⊟Function

• reaction:
  EC 2.7.7.7?  ExPASy
  DNA-directed DNA polymerase Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
• TIGRFAM:
• TheSEED: see SPN034156_14950
• PFAM:
  no clan defined IMS; impB/mucB/samB family (PF00817; HMM-score: 166.6)
  and 5 more
  IMS_C; impB/mucB/samB family C-terminal domain (PF11799; HMM-score: 67.4)
  HHH (CL0198) IMS_HHH; IMS family HHH motif (PF11798; HMM-score: 30.6)
  DNA_pol_lambd_f; Fingers domain of DNA polymerase lambda (PF10391; HMM-score: 14.4)
  FAD_PCMH (CL0077) FAD_binding_5; FAD binding domain in molybdopterin dehydrogenase (PF00941; HMM-score: 12.4)
  no clan defined Toxin_10; Insecticidal Crystal Toxin, P42 (PF05431; HMM-score: 12)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9955
  • Cytoplasmic Membrane Score: 0.0022
  • Cell wall & surface Score: 0.0003
  • Extracellular Score: 0.0021
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.007485
  • TAT(Tat/SPI): 0.001243
  • LIPO(Sec/SPII): 0.002607
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000904582 NCBI
• UniProt:

⊟Protein sequence

• MLIFPLLNDLSRKIIHIDMDAFFAAVEIRDNPKLRGKPVIIGSDPRQTGGRGVVSTCSYEARAFGVHSAMSSKEAYERCPQAVFISGNYEKYKAVGLQIRAIFKRYTDLIEPMSIDEAYLDVTENKLGIKSAVKIARLIQKDIWQELHLTASAGISYNKFLAKMASDYQKPHGLTVILPEQAEDFLKQMNISKFHGVGKKTVERLHQMGVFTGADLLEVPEVTLIDRFGRLGYDLYRKARGIHNSPVKSNRIRKSIGKEKTYGKILRAEEDIKKELTLLSEKVALNLHQQEKAGKIVILKIRYEDFSTLTKRKSLAQKTQDASQISQIALQLYEELSEKERGVRLLGITMTGF

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V: SPV_0419 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications