PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 24-APR-2025

⊟Summary

• organism: Streptococcus pneumoniae SPN034183
• locus tag: SPN034183_RS04855 [old locus tag: SPN034183_08930 ]
• pan locus tag^?: PNEUPAN001992000
• symbol: rocS
• pan gene symbol^?: rocS
• synonym:
• product: chromosome segregation protein RocS

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPN034183_RS04855 [old locus tag: SPN034183_08930 ]
• symbol: rocS
• product: chromosome segregation protein RocS
• replicon: chromosome
• strand: +
• coordinates: 901236..901727
• length: 492
• essential: unknown

⊟Accession numbers

• Location: NC_021028 (901236..901727) NCBI
• BioCyc:
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0878 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  
  ATGAGTATTGAAATGACCGTCAGTGAGATTGCAGAGGTCTTAGGATTATCTCGCCAAGCA
  ATCAATAACCGTGTCAAAGAATTACCAGAAGAAGACACAGATAAAAATGACAAAGGGGTA
  ACAGTTGTTACCAGAAGTGGCTTGATTAAGCTAGAAGAAATCTATAAAAAAACGATTTTT
  GAAGATGAGCCTGTCAGTGAAGATGTCAAACAACGTGAACTGATGGAGATTCTAGTGGAT
  GAGAAGAATGCAGAAATTCTTCGTCTTTATGAACAATTAAAAGCCAAGGATCGTCAGTTA
  TCAGAAAAAGACGAGCAGATGCGTATCAAAGACCGTCAGATTGCTGAGAAAGACAAACAA
  TTAGATCAGCAACAACAATTGACCCTTCAAGCCATGAAGGATCAAGAAAATCTTAAGCTA
  GAGCTGGACCAAGCAAAAGAAGAAGTCCAATCCACTAAGAAAGGCTTTTTTGCTCGTTTA
  TTTGGAGGATAA
  60
  120
  180
  240
  300
  360
  420
  480
  492
  

⊟Protein

⊟General

• locus tag: SPN034183_RS04855 [old locus tag: SPN034183_08930 ]
• symbol: RocS
• description: chromosome segregation protein RocS
• length: 163
• theoretical pI: 4.58434
• theoretical MW: 18970.4
• GRAVY: -0.851534

⊟Function

• TIGRFAM:
  probable regulatory domain (TIGR03879; HMM-score: 16.1)
  Signal transduction Regulatory functions DNA interactions biotin operon repressor (TIGR00122; HMM-score: 15.4)
  Unknown function General DNA binding domain, excisionase family (TIGR01764; HMM-score: 14.6)
  and 4 more
  RNA polymerase sigma factor, sigma-70 family (TIGR02937; HMM-score: 12.5)
  RNA polymerase sigma-70 factor, Bacteroides expansion family 1 (TIGR02985; HMM-score: 11)
  Genetic information processing Transcription Degradation of RNA ribonuclease Y (TIGR03319; EC 3.1.-.-; HMM-score: 10.2)
  Genetic information processing Mobile and extrachromosomal element functions Plasmid functions integrating conjugative element protein, PFL_4705 family (TIGR03752; HMM-score: 6.5)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  no clan defined DUF536; Protein of unknown function, DUF536 (PF04394; HMM-score: 66.7)
  and 23 more
  HTH (CL0123) HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 23.6)
  MarR_2; MarR family (PF12802; HMM-score: 22.8)
  HTH_AsnC-type; AsnC-type helix-turn-helix domain (PF13404; HMM-score: 21.5)
  DUF1323; Putative transcription regulator (DUF1323) (PF07037; HMM-score: 20.8)
  HTH_23; Homeodomain-like domain (PF13384; HMM-score: 20.8)
  HTH_Mga; M protein trans-acting positive regulator (MGA) HTH domain (PF08280; HMM-score: 20.3)
  HTH_11; HTH domain (PF08279; HMM-score: 19.2)
  HTH_Crp_2; Crp-like helix-turn-helix domain (PF13545; HMM-score: 18.4)
  HTH_29; Winged helix-turn helix (PF13551; HMM-score: 16.8)
  Sigma70_r4; Sigma-70, region 4 (PF04545; HMM-score: 16.5)
  no clan defined FAM76; FAM76 protein (PF16046; HMM-score: 16.5)
  HTH (CL0123) Sigma70_r4_2; Sigma-70, region 4 (PF08281; HMM-score: 16.3)
  HTH_17; Helix-turn-helix domain (PF12728; HMM-score: 15.2)
  MarR; MarR family (PF01047; HMM-score: 14.8)
  HTH_20; Helix-turn-helix domain (PF12840; HMM-score: 14.5)
  TrmB; Sugar-specific transcriptional regulator TrmB (PF01978; HMM-score: 13.2)
  HTH_Tnp_ISL3; Helix-turn-helix domain of transposase family ISL3 (PF13542; HMM-score: 12.6)
  HTH_28; Helix-turn-helix domain (PF13518; HMM-score: 12.5)
  no clan defined RNase_Y_N; RNase Y N-terminal region (PF12072; HMM-score: 12.3)
  FAM60A; Protein Family FAM60A (PF15396; HMM-score: 9.8)
  Exonuc_VII_L; Exonuclease VII, large subunit (PF02601; HMM-score: 9.5)
  DUF4407; Domain of unknown function (DUF4407) (PF14362; HMM-score: 7.6)
  TMEM131_like; Transmembrane protein 131-like (PF19532; HMM-score: 6.8)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9801
  • Cytoplasmic Membrane Score: 0.0052
  • Cell wall & surface Score: 0.0108
  • Extracellular Score: 0.0038
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.004489
  • TAT(Tat/SPI): 0.000371
  • LIPO(Sec/SPII): 0.001631
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000021242 NCBI
• UniProt:

⊟Protein sequence

• MSIEMTVSEIAEVLGLSRQAINNRVKELPEEDTDKNDKGVTVVTRSGLIKLEEIYKKTIFEDEPVSEDVKQRELMEILVDEKNAEILRLYEQLKAKDRQLSEKDEQMRIKDRQIAEKDKQLDQQQQLTLQAMKDQENLKLELDQAKEEVQSTKKGFFARLFGG

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V: SPV_0878 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications