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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN034183
  • locus tag: SPN034183_RS07765 [old locus tag: SPN034183_14310 ]
  • pan locus tag?: PNEUPAN003041000
  • symbol: SPN034183_RS07765
  • pan gene symbol?: sirH
  • synonym:
  • product: sensor histidine kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN034183_RS07765 [old locus tag: SPN034183_14310 ]
  • symbol: SPN034183_RS07765
  • product: sensor histidine kinase
  • replicon: chromosome
  • strand: -
  • coordinates: 1452210..1453184
  • length: 975
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_021028 (1452210..1453184) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1445 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    ATGCTTGATTGGAAACAATTTTTTCTAGCCTATCTGCGCTCCCGTAGTCGTCTTTTTGTC
    TATCTGCTTTCTTTGGCATTTCTGGTCTTACTCTTTCAGTTTTTATTTGCCAGTCTAGGA
    ATTTACTTCCTCTACTTTTTCCTCTTGTGTTGCTTTGTAACCATCTTATTTTTCACTTGG
    GACATATTGGTGGAAATGCAGGTCTATCGCCAGGAACTTCTCTATGGAGAGAGGGAAGCC
    AAGTCTCCTTTGGAAATAGCTTTAGCAGAAAAATTAGAAGCGCGTGAGATGGAACTCTAT
    CAGCAGAGGTCAAAAGCAGAAAGAAAACTGACGGATTTGCTGGATTACTATACCTTGTGG
    GTCCATCAGATAAAGACCCCCATTGCAGCCAGTCAACTCTTAGTTGCAGAAGTGGTCGAC
    CGCCAACTGAAGCAGCAGCTAGAACAGGAAATTTTCAAAATCGACTCCTATACCAACCTA
    GTTTTACAGTACCTGCGTTTAGAAAGTTTCCATGATGATTTGGTCTTAAAGCAGGTTCAA
    ATTGAGGACTTGGTCAAGGAAATAATTCGTAAATATGCTCTTTTCTTTATTCAAAAAGGC
    TTAAATGTCAATCTACATGACCTTGATAAAGAAATCGTGACGGATAAAAAGTGGCTGCTA
    GTGGTTATTGAGCAAATCATCTCAAACAGTCTCAAGTACACCAAGGAAGGTGGTCTGGAG
    ATTTATATGGATGACCAAGAGCTTTGTATCAAAGATACGGGAATCGGGATAAAAAATAGT
    GATGTCCTCCGAGTATTTGAACGTGGCTTTTCAGGATACAATGGCCGTTTGACCCAGCAG
    TCCTCTGGACTTGGCCTTTATCTATTTAAGAAAATTTCTGAAGAACTGGGGCACCAGATT
    CGTATCGAGTCTGAGGTCGGAAAAGGAACGACAGTGCGGATTCAGTTTGCTCAAGTGAAC
    TTAGTCCTTGAGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    975

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN034183_RS07765 [old locus tag: SPN034183_14310 ]
  • symbol: SPN034183_RS07765
  • description: sensor histidine kinase
  • length: 324
  • theoretical pI: 5.51789
  • theoretical MW: 38126.2
  • GRAVY: 0.0901235

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.13.3?  ExPASy
    Histidine kinase ATP + protein L-histidine = ADP + protein N-phospho-L-histidine
  • TIGRFAM:
    Signal transduction Signal transduction Two-component systems phosphate regulon sensor kinase PhoR (TIGR02966; EC 2.7.3.-; HMM-score: 66.9)
    Signal transduction Signal transduction Two-component systems TMAO reductase sytem sensor TorS (TIGR02956; EC 2.7.13.3; HMM-score: 53.8)
    and 8 more
    Genetic information processing Protein fate Protein and peptide secretion and trafficking putative PEP-CTERM system histidine kinase (TIGR02916; EC 2.7.13.3; HMM-score: 42.5)
    Signal transduction Signal transduction Two-component systems putative PEP-CTERM system histidine kinase (TIGR02916; EC 2.7.13.3; HMM-score: 42.5)
    heavy metal sensor kinase (TIGR01386; EC 2.7.13.3; HMM-score: 37.3)
    Metabolism Central intermediary metabolism Nitrogen fixation nitrogen fixation negative regulator NifL (TIGR02938; HMM-score: 17.6)
    Signal transduction Regulatory functions Protein interactions nitrogen fixation negative regulator NifL (TIGR02938; HMM-score: 17.6)
    proteobacterial dedicated sortase system histidine kinase (TIGR03785; HMM-score: 15.8)
    Cellular processes Cellular processes Sporulation and germination anti-sigma F factor (TIGR01925; EC 2.7.11.1; HMM-score: 13.9)
    Signal transduction Regulatory functions Protein interactions anti-sigma F factor (TIGR01925; EC 2.7.11.1; HMM-score: 13.9)
  • TheSEED: see SPN034183_14310
  • PFAM:
    His_Kinase_A (CL0025) HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518; HMM-score: 63.7)
    and 2 more
    HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF13589; HMM-score: 17)
    no clan defined TgpA_N; TgpA N-terminal domain (PF11992; HMM-score: 6.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.05
    • Cytoplasmic Membrane Score: 8.78
    • Cellwall Score: 0.08
    • Extracellular Score: 0.09
    • Internal Helices: 2
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0004
    • Cytoplasmic Membrane Score: 0.9986
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.001
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.000922
    • TAT(Tat/SPI): 0.000987
    • LIPO(Sec/SPII): 0.145991
  • predicted transmembrane helices (TMHMM): 2

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000887971 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MLDWKQFFLAYLRSRSRLFVYLLSLAFLVLLFQFLFASLGIYFLYFFLLCCFVTILFFTWDILVEMQVYRQELLYGEREAKSPLEIALAEKLEAREMELYQQRSKAERKLTDLLDYYTLWVHQIKTPIAASQLLVAEVVDRQLKQQLEQEIFKIDSYTNLVLQYLRLESFHDDLVLKQVQIEDLVKEIIRKYALFFIQKGLNVNLHDLDKEIVTDKKWLLVVIEQIISNSLKYTKEGGLEIYMDDQELCIKDTGIGIKNSDVLRVFERGFSGYNGRLTQQSSGLGLYLFKKISEELGHQIRIESEVGKGTTVRIQFAQVNLVLE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Nicolás M Reinoso-Vizcaíno, Melina B Cian, Paulo R Cortes, Nadia B Olivero, Mirelys Hernandez-Morfa, Germán E Piñas, Chandan Badapanda, Ankita Rathore, Daniel R Perez, José Echenique
The pneumococcal two-component system SirRH is linked to enhanced intracellular survival of Streptococcus pneumoniae in influenza-infected pulmonary cells.
PLoS Pathog: 2020, 16(8);e1008761
[PubMed:32790758] [WorldCat.org] [DOI] (I e)

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