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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 06-FEB-2015

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ATCC 700669
  • locus tag: SPN23F10860 [new locus tag: SPN23F_RS05515 ]
  • pan locus tag?: PNEUPAN002451000
  • symbol: lacE2
  • pan gene symbol?: lacE-2
  • synonym:
  • product: putative lactose-specific phosphotransferase system (PTS), IIBC component 2

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN23F10860 [new locus tag: SPN23F_RS05515 ]
  • symbol: lacE2
  • product: putative lactose-specific phosphotransferase system (PTS), IIBC component 2
  • replicon: chromosome
  • strand: -
  • coordinates: 1065429..1067123
  • length: 1695
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    ATGGATAAGTTAATAATTTTTATTGAGAAAGGAAAGCCTTTCTTTGAGAAATTATCGAGA
    AATATATACTTAAGAGCGATAAAAGATGGTTTTATTTCCAGTATGCCAGCAGTATTATTC
    TCAAGTATTTTTATACTAATAGCTGCTGTGCCCAATATTTTTGGGTTTAAATGGTCTGAT
    GAACAGTTAGCTTTTATTTTGAAACCTTACAACTACTCAATGGGGATTTTAGCTCTCTTA
    GTAGCTGGGACAACTGCAAAATCGTTAACAGATTCAGTTAATACACGTAGTATGGAGAAA
    ACCAACCAAATCAACTACATGTCAACTTTTTTAGCAGCTGTTGTTGGATTGTTAATACTG
    GCAGCTGATCCAATTGAAGGTGGATTTGCTAATGGTCTTTTAGGTACTAGAGGATTACTT
    ACTGCATTTTTGGCAGCTTTTATTACAGTAAATATCTATAAAGTATGTATTAAAAATAAT
    GTAACCATTAGACTTCCTGAAGAGGTTCCACCAAATATTGCACAAGTTTTTAAAGATGTT
    ATTCCGTTTGCCTTATCTGTTCTTTCAATATATGGATTGGATTTAATTGTTAGAAATATT
    TTTGGTACAAATGTAGCAGAATCTGTTGGTAAAATATTAGCCCCTCTATTTTCAGCTACT
    GATGGTTATATCGGTTTAGCTATTGTATTTGGTGCTTATGCTTTCTTTTGGTTTGTTGGA
    ATTCATGGGCCATCTGTTGTAGAACCTTTAATTGTAGCTATCAGTTATGCAAATATAGAA
    GCTAATGTTCAGCTTGTGCAAGCTGGTATGCACGCAGATAAAATTTTAAATCCAGTTACT
    CAAACTTTTGTTGTAACAATGGGTGGTACTGGTGCAACACTAGTAGTTCCATTTATGTTT
    ATGTGGTTATGTAAATCAAAAAGAAATAGAATTGTCGGACGTGCGTCTGTAGTTCCTACT
    TTCTTTGGCGTAAATGAACCAATCCTATTTGGTGCTCCAATTGTTTTAAATCCTATCTTC
    TTTATTCCGTTTGTTACTGCTCCTATTATCAATGTTTGGATTATGAAATTTTTTGTAGAT
    GTTCTACAAATGAATAGTTTCAGTATTATTTTACCTTGGACAACACCTGCTCCAATTGGT
    ATTGTTATGGGAACGGCGCTGGCTCCATTGTCATTCGTCTTGGCTATAACTTTAATCATT
    ATCGACACTTTAATCTATTATCCATTTGTTAAAGTTTATGACCATCAAATTTTAGAAGAA
    GAACGGAAAGGAAACTCTTCATCTGAATTGAAAGAAAAAGTTGCTGCAAACTTCAACACT
    GCAAAAGCGGATGCTATTCTTGAAAAAGCGGGTGTCGATGCAGCACAAAATACCATCACT
    GAAGAAACAAATGTCCTCGTTCTCTGTGCTGGTGGAGGTACAAGTGGACTCCTTGCAAAT
    GCTTTGAATAAGGCAGCAGCAGAATACAATGTCCCTGTGAAAGCAGCAGCAGGCGGCTAT
    GGTGCTCACCGTGAAATGTTACCAGAGTTTAATCTAGTTATCCTTGCCCCTCAAGTTGCT
    TCAAACTTTGAAGATATGAAGGCAGAAACAGATAAGCTCGGTATTAAACTTGCTAAGACA
    GAAGGCGCTCAATACATCAAATTAACTCGTGATGGAAAAGGTGCCCTAGCATTCGTACAA
    GAGCAATTCGATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1695

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN23F10860 [new locus tag: SPN23F_RS05515 ]
  • symbol: LacE2
  • description: putative lactose-specific phosphotransferase system (PTS), IIBC component 2
  • length: 564
  • theoretical pI: 6.94151
  • theoretical MW: 61139.4
  • GRAVY: 0.544149

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.1.69?  ExPASy
    Transferred entry: 2.7.1.191, 2.7.1.192, 2.7.1.193, 2.7.1.194, 2.7.1.195, 2.7.1.196, 2.7.1.197, 2.7.1.198, 2.7.1.199, 2.7.1.200, 2.7.1.201, 2.7.1.202, 2.7.1.203, 2.7.1.204, 2.7.1.205, 2.7.1.206, 2.7.1.207 and 2.7.1.208
  • TIGRFAM:
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, lactose-specific IIC component (TIGR00394; EC 2.7.1.69; HMM-score: 677.2)
    Signal transduction Signal transduction PTS PTS system, lactose-specific IIC component (TIGR00394; EC 2.7.1.69; HMM-score: 677.2)
    and 8 more
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, cellobiose-specific IIC component (TIGR00359; EC 2.7.1.69; HMM-score: 242.4)
    Signal transduction Signal transduction PTS PTS system, cellobiose-specific IIC component (TIGR00359; EC 2.7.1.69; HMM-score: 242.4)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, lactose/cellobiose family IIC component (TIGR00410; EC 2.7.1.69; HMM-score: 242.4)
    Signal transduction Signal transduction PTS PTS system, lactose/cellobiose family IIC component (TIGR00410; EC 2.7.1.69; HMM-score: 242.4)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, lactose/cellobiose family IIB component (TIGR00853; HMM-score: 193.6)
    Signal transduction Signal transduction PTS PTS system, lactose/cellobiose family IIB component (TIGR00853; HMM-score: 193.6)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA 2-selenouridine synthase (TIGR03167; EC 2.9.1.-; HMM-score: 12.6)
    Genetic information processing Mobile and extrachromosomal element functions Prophage functions holin, phage phi LC3 family (TIGR01598; HMM-score: 8.5)
  • TheSEED  :
    • PTS system, lactose-specific IIB component (EC 2.7.1.69)
    • PTS system, lactose-specific IIC component (EC 2.7.1.69)
    Carbohydrates Di- and oligosaccharides Lactose and Galactose Uptake and Utilization  PTS system, lactose-specific IIB component (EC 2.7.1.69)
    and 1 more
    Carbohydrates Di- and oligosaccharides Lactose and Galactose Uptake and Utilization  PTS system, lactose-specific IIC component (EC 2.7.1.69)
  • PFAM:
    PTS_EIIC (CL0493) PTS_EIIC; Phosphotransferase system, EIIC (PF02378; HMM-score: 216.2)
    and 2 more
    Phosphatase (CL0031) PTS_IIB; PTS system, Lactose/Cellobiose specific IIB subunit (PF02302; HMM-score: 35.2)
    no clan defined NBD_C; Nucleotide-binding C-terminal domain (PF17042; HMM-score: 14.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 8
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.00413
    • TAT(Tat/SPI): 0.000334
    • LIPO(Sec/SPII): 0.001487
  • predicted transmembrane helices (TMHMM): 8

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: CAR68899 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MDKLIIFIEKGKPFFEKLSRNIYLRAIKDGFISSMPAVLFSSIFILIAAVPNIFGFKWSDEQLAFILKPYNYSMGILALLVAGTTAKSLTDSVNTRSMEKTNQINYMSTFLAAVVGLLILAADPIEGGFANGLLGTRGLLTAFLAAFITVNIYKVCIKNNVTIRLPEEVPPNIAQVFKDVIPFALSVLSIYGLDLIVRNIFGTNVAESVGKILAPLFSATDGYIGLAIVFGAYAFFWFVGIHGPSVVEPLIVAISYANIEANVQLVQAGMHADKILNPVTQTFVVTMGGTGATLVVPFMFMWLCKSKRNRIVGRASVVPTFFGVNEPILFGAPIVLNPIFFIPFVTAPIINVWIMKFFVDVLQMNSFSIILPWTTPAPIGIVMGTALAPLSFVLAITLIIIDTLIYYPFVKVYDHQILEEERKGNSSSELKEKVAANFNTAKADAILEKAGVDAAQNTITEETNVLVLCAGGGTSGLLANALNKAAAEYNVPVKAAAGGYGAHREMLPEFNLVILAPQVASNFEDMKAETDKLGIKLAKTEGAQYIKLTRDGKGALAFVQEQFD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CcpA regulon
    CcpA(TF)important in Global catabolite repression; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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