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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 06-FEB-2015
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae ATCC 700669
- locus tag: SPN23F10890 [new locus tag: SPN23F_RS05530 ]
- pan locus tag?: PNEUPAN002431000
- symbol: lacD2
- pan gene symbol?: lacD
- synonym:
- product: tagatose 1,6-diphosphate aldolase 2
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SPN23F10890 [new locus tag: SPN23F_RS05530 ]
- symbol: lacD2
- product: tagatose 1,6-diphosphate aldolase 2
- replicon: chromosome
- strand: -
- coordinates: 1068548..1069528
- length: 981
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: FM211187 (1068548..1069528) NCBI
- BioCyc: see SPN23F_RS05530
- MicrobesOnline: 5830942 MicrobesOnline
- PneumoBrowse for strain D39V: SPV_2301 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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961ATGGCTTTAACAGAACAAAAACGTGTACGCTTAGAAAAACTTTCTGATGAAAATGGTATC
ATCTCAGCTCTTGCATTTGACCAACGTGGTGCTTTGAAACGCCTCATGGCTCAACACCAA
ACAGAAGAACCAACTGTGGCCCAAATGGAAGAACTTAAAGTCTTGGTAGCAGATGAATTG
ACTAAATACGCTTCATCTATGCTTCTTGACCCTGAGTATGGACTTCCAGCAACTAAAGCT
CTTGATGAAAAAGCTGGTCTTCTCCTTGCTTATGAAAAAACAGGTTATGACACAACAAGC
ACAAAACGCTTGCCAGACTGCTTGGATGTCTGGTCTGCAAAACGTATTAAAGAAGAAGGT
GCAGATGCAGTTAAATTCTTGCTTTACTATGATGTAGATAGCTCAGACGAACTCAATCAA
GAAAAACAAGCCTACATCGAACGCATCGGTTCTGAGTGTGTGGCTGAAGATATCCCATTC
TTCCTTGAAATTCTTGCTTACGATGAAAAAATTGCGGATGCAGGTTCTGTAGAATACGCG
AAAGTAAAACCACACAAAGTTATCGGCGCTATGAAAGTCTTTTCAGACCCACGCTTTAAC
ATTGATGTCTTGAAAGTTGAAGTTCCTGTTAACATTAAATATGTTGAAGGCTTCGCTGAA
GGTGAAGTAGTTTATACACGTGAAGAAGCAGCAGCCTTCTTCAAAGCGCAAGATGAAGCA
ACGAACTTGCCATACATCTACTTGAGTGCTGGTGTATCAGCTAAACTCTTCCAAGATACT
CTTGTATTTGCTCATGAATCAGGTGCAAACTTTAACGGAGTTCTTTGTGGCCGTGCAACA
TGGGCTGGATCAGTTGAAGCATACATCAAAGATGGTGAAACAGCAGCTCGCGAATGGCTT
CGCACAACTGGATTTGAAAACATTGATGAGCTCAACAAAGTTCTTCAAACAACAGCAACT
TCATGGAAAGAACGTGTGTAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SPN23F10890 [new locus tag: SPN23F_RS05530 ]
- symbol: LacD2
- description: tagatose 1,6-diphosphate aldolase 2
- length: 326
- theoretical pI: 4.47038
- theoretical MW: 36416
- GRAVY: -0.264417
⊟Function[edit | edit source]
- reaction: EC 4.1.2.40? ExPASyTagatose-bisphosphate aldolase D-tagatose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate
- TIGRFAM: Energy metabolism Biosynthesis and degradation of polysaccharides tagatose 1,6-diphosphate aldolase (TIGR01232; EC 4.1.2.40; HMM-score: 670.1)
- TheSEED :
- Tagatose 1,6-bisphosphate aldolase (EC 4.1.2.40)
Carbohydrates Aminosugars N-Acetyl-Galactosamine and Galactosamine Utilization Tagatose 1,6-bisphosphate aldolase (EC 4.1.2.40)and 1 more - PFAM: TIM_barrel (CL0036) DeoC; DeoC/LacD family aldolase (PF01791; HMM-score: 224.3)and 1 moreDUF2090; Uncharacterized protein conserved in bacteria (DUF2090) (PF09863; HMM-score: 22.7)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 7.5
- Cytoplasmic Membrane Score: 1.15
- Cellwall Score: 0.62
- Extracellular Score: 0.73
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9652
- Cytoplasmic Membrane Score: 0.0031
- Cell wall & surface Score: 0.0014
- Extracellular Score: 0.0302
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.001821
- TAT(Tat/SPI): 0.000351
- LIPO(Sec/SPII): 0.000254
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq: CAR68902 NCBI
- UniProt:
⊟Protein sequence[edit | edit source]
- MALTEQKRVRLEKLSDENGIISALAFDQRGALKRLMAQHQTEEPTVAQMEELKVLVADELTKYASSMLLDPEYGLPATKALDEKAGLLLAYEKTGYDTTSTKRLPDCLDVWSAKRIKEEGADAVKFLLYYDVDSSDELNQEKQAYIERIGSECVAEDIPFFLEILAYDEKIADAGSVEYAKVKPHKVIGAMKVFSDPRFNIDVLKVEVPVNIKYVEGFAEGEVVYTREEAAAFFKAQDEATNLPYIYLSAGVSAKLFQDTLVFAHESGANFNGVLCGRATWAGSVEAYIKDGETAAREWLRTTGFENIDELNKVLQTTATSWKERV
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- MicrobesOnline: lacD2 < lacC2 < lacB1 < lacA
⊟Regulation[edit | edit source]
- regulator: LacR* (repression) regulon
LacR* (TF) important in Lactose utilization, Galactose utilization; RegPrecise transcription unit transferred from TIGR4 data RegPrecise
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_2301 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]