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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 06-FEB-2015

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ATCC 700669
  • locus tag: SPN23F22010 [new locus tag: SPN23F_RS11315 ]
  • pan locus tag?: PNEUPAN003872000
  • symbol: adcA
  • pan gene symbol?: adcA
  • synonym:
  • product: zinc-binding protein AdcA precursor

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN23F22010 [new locus tag: SPN23F_RS11315 ]
  • symbol: adcA
  • product: zinc-binding protein AdcA precursor
  • replicon: chromosome
  • strand: -
  • coordinates: 2148625..2150130
  • length: 1506
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    GTGAAAAAAATTAGCTTATTACTAGCCAGTCTATGTGCCTTGTTTTTAGTGGCTTGTTCC
    AATCAAAAACAGGCAGATGGTAAACTCAATATCGTGACAACCTTTTACCCTGTCTATGAA
    TTTACCAAGCAAGTCGCAGGAGATACGGCTAATGTAGAACTCCTAATCGGTGCTGGGACA
    GAACCTCATGAATACGAACCATCTGCCAAGGCAGTTGCCAAAATCCAAGATGCAGATACC
    TTCGTTTATGAAAATGAAAACATGGAAACATGGGTACCTAAATTGCTAGATACCTTGGAT
    AAGAAAAAAGTGAAAACCATCAAGGCGACAGGCGATATGTTGCTCTTGCCAGGTGGCGAG
    GAAGAAGAGGGAGACCATGACCATGGAGAAGAAGGTCATCACCATGAGTTTGATCCCCAT
    GTTTGGTTATCACCAGTTCGTGCCATTAAACTAGTAGAGCACATTCGTGACAGCTTGTCA
    GCAGATTATCCTGATAAAAAAGAGACCTTTGAGAAGAATGCAGCTGCCTATATCGAAAAA
    TTGCAAGCCTTGGATAAGGCTTACGCAGAAGGCTTGTCTCAAGCAAAACAAAAGAGCTTT
    GTGACTCAACACGCAGCCTTTAACTATCTTGCCTTGGACTATGGACTCAAACAAGTCGCA
    ATCTCAGGACTTTCTCCAGATGTAGAGCCATCAGCTGCTCGCTTGGCAGAATTGACAGAG
    TATGTCAAGAAAAATAAAATCGCCTATATCTATTTTGAAGAAAATGCCTCACAAGCCCTT
    GCTAACACACTTTCAAAAGAAGCAGGTGTCAAAACTGATGTCCTCAATCCTTTAGAAAGT
    CTGACAGAAGAGGACACCAAGGCTGGAGAAAATTACATCTCTATCATGGAGAAAAACCTC
    AAGGCTTTGAAACAAACAACAGACCAAGAAGGCCCAGCAATCGAGCCTGAAAAGGCAGAG
    GATACCAAGACAGTCCAAAATGGTTACTTCGAGGATGCAGCTGTCAAGGACCGCACCTTG
    AGTGACTATGCAGGTAACTGGCAATCAGTTTATCCTTTCCTTGAAGACGGCACGTTTGAC
    CAAGTCTTTGACTACAAGGCTAAGTTGACTGGTAAGATGACCCAGGCTGAGTACAAGGCT
    TACTATACAAAAGGCTATCAGACAGATGTGACTAAGATTAACATTACTGATAATACTATG
    GAATTTGTTCAAGGTGGACAAAGCAAGAAATATACTTACAAGTATGTCGGTAAGAAAATT
    TTGACTTACAAGAAAGGCAATCGTGGCGTGCGTTTCCTCTTTGAAGCCACAGATGCTGAC
    GCTGGACAATTCAAGTATGTTCAGTTTAGTGACCACAATGTTGCCCCAGTTAAGGCAGAA
    CATTTCCATATCTTTTTTGGAGGTACAAGCCAAGAAGCTCTATTTGAAGAAATGGATAAT
    TGGCCAACCTACTACCCAGATAACCTATCTGGCCAAGAAATCGCTCAAGAAATGTTGGCG
    CATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1506

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN23F22010 [new locus tag: SPN23F_RS11315 ]
  • symbol: AdcA
  • description: zinc-binding protein AdcA precursor
  • length: 501
  • theoretical pI: 4.80636
  • theoretical MW: 56253.6
  • GRAVY: -0.547904

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Unknown substrate anchored repeat ABC transporter, substrate-binding protein (TIGR03772; HMM-score: 109.5)
  • TheSEED  :
    • Candidate zinc-binding lipoprotein ZinT
  • PFAM:
    Calycin (CL0116) ZinT; ZinT (YodA) periplasmic lipocalin-like zinc-recruitment (PF09223; HMM-score: 287.5)
    Chelatase (CL0043) ZnuA; Zinc-uptake complex component A periplasmic (PF01297; HMM-score: 256)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.17
    • Cytoplasmic Membrane Score: 9.51
    • Cellwall Score: 0.16
    • Extracellular Score: 0.15
    • Internal Helices: 0
  • SignalP: Signal peptide LIPO(Sec/SPII) length 18 aa
    • SP(Sec/SPI): 0.002123
    • TAT(Tat/SPI): 0.000062
    • LIPO(Sec/SPII): 0.997603
    • Cleavage Site: CS pos: 18-19. LVA-CS. Pr: 0.9981
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: CAR69934 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKKISLLLASLCALFLVACSNQKQADGKLNIVTTFYPVYEFTKQVAGDTANVELLIGAGTEPHEYEPSAKAVAKIQDADTFVYENENMETWVPKLLDTLDKKKVKTIKATGDMLLLPGGEEEEGDHDHGEEGHHHEFDPHVWLSPVRAIKLVEHIRDSLSADYPDKKETFEKNAAAYIEKLQALDKAYAEGLSQAKQKSFVTQHAAFNYLALDYGLKQVAISGLSPDVEPSAARLAELTEYVKKNKIAYIYFEENASQALANTLSKEAGVKTDVLNPLESLTEEDTKAGENYISIMEKNLKALKQTTDQEGPAIEPEKAEDTKTVQNGYFEDAAVKDRTLSDYAGNWQSVYPFLEDGTFDQVFDYKAKLTGKMTQAEYKAYYTKGYQTDVTKINITDNTMEFVQGGQSKKYTYKYVGKKILTYKKGNRGVRFLFEATDADAGQFKYVQFSDHNVAPVKAEHFHIFFGGTSQEALFEEMDNWPTYYPDNLSGQEIAQEMLAH

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: AdcR* (repression) regulon
    AdcR*(TF)important in Zinc homeostasis; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Charles D Plumptre, Bart A Eijkelkamp, Jacqueline R Morey, Felix Behr, Rafael M Couñago, Abiodun D Ogunniyi, Bostjan Kobe, Megan L O'Mara, James C Paton, Christopher A McDevitt
AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in Streptococcus pneumoniae.
Mol Microbiol: 2014, 91(4);834-51
[PubMed:24428621] [WorldCat.org] [DOI] (I p)

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