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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 11-FEB-2025
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae ATCC 700669
- locus tag: SPN23F_RS00390 [old locus tags: SPN23F00740 SPN23F_00740 ]
- pan locus tag?: PNEUPAN000684000
- symbol: SPN23F_RS00390
- pan gene symbol?: agaR
- synonym: cpsR
- product: GntR family transcriptional regulator
⊟Additional information (user-provided)[edit | edit source]
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SPN23F_RS00390 [old locus tags: SPN23F00740 SPN23F_00740 ]
- symbol: SPN23F_RS00390
- product: GntR family transcriptional regulator
- replicon: chromosome
- strand: -
- coordinates: 73355..74071
- length: 717
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: NC_011900 (73355..74071) NCBI
- BioCyc: SPN23F_RS00390 BioCyc
- MicrobesOnline: see SPN23F00740
- PneumoBrowse for strain D39V: SPV_0064 PneumoBrowse
⊟Phenotype[edit | edit source]
⊟Additional information (user-provided)[edit | edit source]
⊟DNA sequence[edit | edit source]
- 1
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661ATGGCAATTCCCAAATATCAATACATAAAAGACGAATTAAAAAATAAAATCATCTCTGGG
CAGTTTAGCAGTGGAGATAAATTTTACACTGAAGCAGAACTCATTTCAATGTACGATGTC
AGCTCTATCACAGTTGTTCGCGCCTTAAACGACCTTGCCAAAGATGGCTATATTGTCCGC
CAACAAGGAAAAGGAACCTTCATTTCACGTGCACGCAAACACAAGCTTGTAGAGTTTTCA
GATATTGAACTCTTCAATGCTAAAGATGATAAGGTAACTGTTCTTTCAATTGAACGCGGA
AACAAGCTTGTTTACTTGGAAAAATTGGGTCTACGCGGCGATCAATTCTACTACAAGATT
GAACGTATCCGCGAATCAAACGGTGTCGTTTATATCTACCATACATCCTACATCCCAGAA
CAATATATCAACGCAAATTATCCAAATCTTGAATACTATAGTTCTATCTATAATCGTTTC
AAGTTAGACTACCACATTCACATGAATGATGAACACTTTGAAGAAATCAACGAAATAGTC
TTTCCAACTCCAGAACATGCGGCTTCAGTCCTCGGAGTCGATGAACAATTCCCTACTGTC
CTACAAACTAAAATCACCAAACTCGAATCAACTGGCCAAGTTTTAGAATACAGTGAAACT
TACAAACGATCTGATTACTACAAGATTAAATTCATCTCATGTGACCGTGATCACTAA60
120
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660
717
⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SPN23F_RS00390 [old locus tags: SPN23F00740 SPN23F_00740 ]
- symbol: SPN23F_RS00390
- description: GntR family transcriptional regulator
- length: 238
- theoretical pI: 6.40701
- theoretical MW: 27948.4
- GRAVY: -0.521008
⊟Function[edit | edit source]
- TIGRFAM: Energy metabolism Amino acids and amines histidine utilization repressor (TIGR02018; HMM-score: 67.7)Regulatory functions DNA interactions histidine utilization repressor (TIGR02018; HMM-score: 67.7)Regulatory functions DNA interactions trehalose operon repressor (TIGR02404; HMM-score: 64.8)Regulatory functions DNA interactions phosphonate utilization transcriptional regulator PhnR (TIGR03337; HMM-score: 62.9)and 6 moreTransport and binding proteins Anions phosphonate metabolism transcriptional regulator PhnF (TIGR02325; HMM-score: 50.4)Regulatory functions DNA interactions phosphonate metabolism transcriptional regulator PhnF (TIGR02325; HMM-score: 50.4)Fatty acid and phospholipid metabolism Biosynthesis fatty acid metabolism transcriptional regulator FadR (TIGR02812; HMM-score: 17.6)Fatty acid and phospholipid metabolism Degradation fatty acid metabolism transcriptional regulator FadR (TIGR02812; HMM-score: 17.6)Regulatory functions DNA interactions fatty acid metabolism transcriptional regulator FadR (TIGR02812; HMM-score: 17.6)phosphonate utilization associated transcriptional regulator (TIGR03338; HMM-score: 15.3)
- TheSEED: see SPN23F00740
- PFAM: UTRA (CL0122) UTRA; UTRA domain (PF07702; HMM-score: 60.7)HTH (CL0123) GntR; Bacterial regulatory proteins, gntR family (PF00392; HMM-score: 58.2)and 6 moreCostars; Costars (PF14705; HMM-score: 18.7)HTH_DeoR; DeoR-like helix-turn-helix domain (PF08220; HMM-score: 15.5)HTH_27; Winged helix DNA-binding domain (PF13463; HMM-score: 14.3)HTH_Crp_2; Crp-like helix-turn-helix domain (PF13545; HMM-score: 14.2)MarR; MarR family (PF01047; HMM-score: 14.1)MarR_2; MarR family (PF12802; HMM-score: 12)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
- genes regulated by AgaR/CpsR*, TF important in N-acetylgalactosamine utilization: see SPN23F00740
⊟Localization[edit | edit source]
- PSORTb: unknown (no significant prediction)
- Cytoplasmic Score: 2.5
- Cytoplasmic Membrane Score: 2.5
- Cellwall Score: 2.5
- Extracellular Score: 2.5
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.972
- Cytoplasmic Membrane Score: 0.0032
- Cell wall & surface Score: 0.0001
- Extracellular Score: 0.0248
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.004281
- TAT(Tat/SPI): 0.000179
- LIPO(Sec/SPII): 0.000372
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq: WP_001007198 NCBI
- UniProt:
⊟Additional information (user-provided)[edit | edit source]
⊟Protein sequence[edit | edit source]
- MAIPKYQYIKDELKNKIISGQFSSGDKFYTEAELISMYDVSSITVVRALNDLAKDGYIVRQQGKGTFISRARKHKLVEFSDIELFNAKDDKVTVLSIERGNKLVYLEKLGLRGDQFYYKIERIRESNGVVYIYHTSYIPEQYINANYPNLEYYSSIYNRFKLDYHIHMNDEHFEEINEIVFPTPEHAASVLGVDEQFPTVLQTKITKLESTGQVLEYSETYKRSDYYKIKFISCDRDH
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- MicrobesOnline: no polycistronic organisation predicted
⊟Regulation[edit | edit source]
- regulator: AgaR/CpsR*, CcpA see SPN23F00740
⊟Additional information (user-provided)[edit | edit source]
⊟Transcription[edit | edit source]
- transcription start site:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_0064 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟'lacZ' fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Additional information (user-provided)[edit | edit source]
⊟Other information (user-provided)[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
Kaifeng Wu, Hongmei Xu, Yuqiang Zheng, Libin Wang, Xuemei Zhang, Yibing Yin
CpsR, a GntR family regulator, transcriptionally regulates capsular polysaccharide biosynthesis and governs bacterial virulence in Streptococcus pneumoniae.
Sci Rep: 2016, 6;29255
[PubMed:27386955] [WorldCat.org] [DOI] (I e)Muhammad Afzal, Sulman Shafeeq, Hifza Ahmed, Oscar P Kuipers
N-acetylgalatosamine-Mediated Regulation of the aga Operon by AgaR in Streptococcus pneumoniae.
Front Cell Infect Microbiol: 2016, 6;101
[PubMed:27672623] [WorldCat.org] [DOI] (I e)