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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 11-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ATCC 700669
  • locus tag: SPN23F_RS01710 [old locus tags: SPN23F03320 SPN23F_03320 ]
  • pan locus tag?: PNEUPAN000568000
  • symbol: SPN23F_RS01710
  • pan gene symbol?: wciA
  • synonym:
  • product: HAD-IIA family hydrolase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN23F_RS01710 [old locus tags: SPN23F03320 SPN23F_03320 ]
  • symbol: SPN23F_RS01710
  • product: HAD-IIA family hydrolase
  • replicon: chromosome
  • strand: +
  • coordinates: 317777..318610
  • length: 834
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_011900 (317777..318610) NCBI
  • BioCyc: SPN23F_RS01710 BioCyc
  • MicrobesOnline: see SPN23F03320
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGAAATTGACAAATAGAGTTGATTATTTTGGTGCTGATATTAGTGAACTTCAGAATAAA
    AAATTATTCTTATTTGATATGGATGGTACCATTTATGAAGAAGATAGGTTGTTTGAGGGT
    ACTCTCGAATTATTAGACTATATTCATAATATTGGCGGTGAGTATATTTTTATTACAAAC
    AATTCATCTAAGTCTGTTGTTGACTATGTTGAAAAAGTTAACAGATTAGGTATTAAAGCT
    GAACGAGATAATTTTTTTACCTCTGCTCAAGCCACAATTGTTTATATTAAAGAAAATTAT
    CCTAAATCTAAAGTTTATTGCCAAGGAACAAAATCTTTGATAAAAGAACTATCTGACGCA
    GGAATTGATGTAACTGAGCAAGTTAGTGCTGATATAGATGTTGTTCTTGTTGGTTTTGAT
    ACAGAATTAACCAGTGATAAAATTCGCAATACCTGCGAGATTCTATCAACAAAGGACGTA
    CCTTTCATAGCTACTAACCCTGATATTCGCTGCCCAGTATCGTTTGGATTCATCCCGGAT
    TGTGGTTCTATTTGTGATATGATTAGTAAATCAGTCGATAGGAAACCTGTTTACATAGGT
    AAACCTGAACCTACGATGGTTGATATTGTTCGAAAAAAATTAAATTATTCTCTATTTGAA
    ACAGTTGTGATTGGAGATCGCTTGTATACGGATATCATGACTGGTATAAATGCAGGAGTA
    ACTTCAGTTTGTGTGCTGACAGGAGAAGCAACGGTGAATGATATTCAACAAGATAGTATA
    AAACCGACTTATACATTTAAAAACGTGAAAGAAATGTGGAAAGGAATTGTCTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    834

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN23F_RS01710 [old locus tags: SPN23F03320 SPN23F_03320 ]
  • symbol: SPN23F_RS01710
  • description: HAD-IIA family hydrolase
  • length: 277
  • theoretical pI: 4.54571
  • theoretical MW: 31112.4
  • GRAVY: -0.116968

⊟Function[edit | edit source]

  • TIGRFAM:
    Unknown function Enzymes of unknown specificity HAD hydrolase, TIGR01457 family (TIGR01457; HMM-score: 161.2)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIA (TIGR01460; HMM-score: 156.1)
    phosphoglycolate/pyridoxal phosphate phosphatase family (TIGR01452; EC 3.1.3.18; HMM-score: 156)
    and 19 more
    HAD hydrolase, TIGR01459 family (TIGR01459; HMM-score: 80.6)
    Unknown function Enzymes of unknown specificity HAD hydrolase, TIGR01458 family (TIGR01458; HMM-score: 52)
    HAD hydrolase, TIGR02253 family (TIGR02253; HMM-score: 36.7)
    noncanonical pyrimidine nucleotidase, YjjG family (TIGR02254; EC 3.1.3.5; HMM-score: 32.4)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIIA (TIGR01662; HMM-score: 31.9)
    HAD phosphatase, family IIIA (TIGR01668; EC 3.1.3.-; HMM-score: 31.8)
    histidinol-phosphate phosphatase domain (TIGR01656; HMM-score: 28.3)
    phosphonatase-like hydrolase (TIGR03351; HMM-score: 22.8)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IA, variant 1 (TIGR01549; HMM-score: 21.6)
    AHBA synthesis associated protein (TIGR01454; HMM-score: 18.2)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides D,D-heptose 1,7-bisphosphate phosphatase (TIGR00213; HMM-score: 17.8)
    Metabolism Central intermediary metabolism Other phosphonoacetaldehyde hydrolase (TIGR01422; EC 3.11.1.1; HMM-score: 16.2)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIB (TIGR01484; HMM-score: 14.6)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IA, variant 3 (TIGR01509; HMM-score: 14.6)
    beta-phosphoglucomutase family hydrolase (TIGR02009; HMM-score: 14.4)
    pyrimidine 5'-nucleotidase (TIGR01993; EC 3.1.3.5; HMM-score: 13.9)
    Unknown function Enzymes of unknown specificity HAD phosphoserine phosphatase-like hydrolase, family IB (TIGR01488; HMM-score: 13.8)
    Metabolism Energy metabolism Sugars phosphoglycolate phosphatase, bacterial (TIGR01449; EC 3.1.3.18; HMM-score: 12.9)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair reverse gyrase (TIGR01054; EC 3.6.4.12,5.99.1.3; HMM-score: 11.3)
  • TheSEED: see SPN23F03320
  • PFAM:
    HAD (CL0137) Hydrolase_6; haloacid dehalogenase-like hydrolase (PF13344; HMM-score: 81)
    and 7 more
    Hydrolase_like; HAD-hyrolase-like (PF13242; HMM-score: 62.3)
    HAD_2; haloacid dehalogenase-like hydrolase (PF13419; HMM-score: 37.3)
    Hydrolase; haloacid dehalogenase-like hydrolase (PF00702; HMM-score: 36)
    PGP_phosphatase; Mitochondrial PGP phosphatase (PF09419; HMM-score: 17.8)
    Hydrolase_3; haloacid dehalogenase-like hydrolase (PF08282; HMM-score: 14.2)
    Acid_phosphat_B; HAD superfamily, subfamily IIIB (Acid phosphatase) (PF03767; HMM-score: 13.6)
    no clan defined DUF2321; Uncharacterized protein conserved in bacteria (DUF2321) (PF10083; HMM-score: 13)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9233
    • Cytoplasmic Membrane Score: 0.0069
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0697
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.00216
    • TAT(Tat/SPI): 0.000118
    • LIPO(Sec/SPII): 0.000221
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000779205 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKLTNRVDYFGADISELQNKKLFLFDMDGTIYEEDRLFEGTLELLDYIHNIGGEYIFITNNSSKSVVDYVEKVNRLGIKAERDNFFTSAQATIVYIKENYPKSKVYCQGTKSLIKELSDAGIDVTEQVSADIDVVLVGFDTELTSDKIRNTCEILSTKDVPFIATNPDIRCPVSFGFIPDCGSICDMISKSVDRKPVYIGKPEPTMVDIVRKKLNYSLFETVVIGDRLYTDIMTGINAGVTSVCVLTGEATVNDIQQDSIKPTYTFKNVKEMWKGIV

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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