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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ATCC 700669
  • locus tag: SPN23F_RS03050 [old locus tags: SPN23F05960 SPN23F_05960 ]
  • pan locus tag?: PNEUPAN001603000
  • symbol: SPN23F_RS03050
  • pan gene symbol?: yesN
  • synonym:
  • product: response regulator transcription factor

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN23F_RS03050 [old locus tags: SPN23F05960 SPN23F_05960 ]
  • symbol: SPN23F_RS03050
  • product: response regulator transcription factor
  • replicon: chromosome
  • strand: +
  • coordinates: 588049..588786
  • length: 738
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGACCTACACAATCTTAATCGTAGAAGATGAATATCTGGTAAGACAAGGTTTGACTAAA
    CTGGTCAATGTAGCAGCCTACGATATGGAAATCATCGGTCAGGCTGAAAATGGAAGGCAG
    GCTTGGGAATTGATCCAAAAGCAGGTGCCAGATATCATTTTAACCGATATCAACATGCCT
    CATCTAAATGGCATCCAGTTGGCCAGTCTGGTACGAGAAACCTATCCTCAGGTTCATTTG
    GTCTTTTTAACAGGTTACGATGATTTTGATTATGCCTTGTCTGCTGTCAAACTAGGTGTG
    GACGACTACCTGCTCAAACCCTTTTCTCGTCAGGATATTGAGGAAATGTTGGGGAAAATC
    AAACAAAAACTAGACAAGGAAGAGAAAGAAGAGCAGTTACAAGATTTATTGACTAATAGG
    TTTGAAGGAAACATGGCCCAGAAAATCCAGTCTCATCTGGCTGATAGCCAATTTAGTTTA
    AAGTCTTTAGCCAGTGACTTAGGTTTTAGTCCGACCTATCTGAGTTCCTTGATTAAGAAA
    GAGTTGGGCTTGCCTTTTCAGGATTATCTGGTGAGAGAACGTGTTAAACAAGCCAAGCTC
    TTGCTTTTAACTACAGATCTGAAGATTTATGAGATCGCAGAGAAGGTTGGTTTTGAAGAT
    ATGAACTATTTTACCCAACGTTTTAAGCAGATTGCAGGTGTGACACCTCGTCAGTTTAAG
    AAGGGAGAAGACCGATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    738

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN23F_RS03050 [old locus tags: SPN23F05960 SPN23F_05960 ]
  • symbol: SPN23F_RS03050
  • description: response regulator transcription factor
  • length: 245
  • theoretical pI: 4.92409
  • theoretical MW: 28262.3
  • GRAVY: -0.311429

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Central intermediary metabolism Nitrogen metabolism nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 65.6)
    Signal transduction Regulatory functions DNA interactions nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 65.6)
    Signal transduction Signal transduction Two-component systems nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 65.6)
    Cellular processes Cellular processes Sporulation and germination sporulation transcription factor Spo0A (TIGR02875; HMM-score: 64.8)
    YSIRK-targeted surface antigen transcriptional regulator (TIGR04094; HMM-score: 61.9)
    Signal transduction Regulatory functions DNA interactions phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 61.2)
    Signal transduction Signal transduction Two-component systems phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 61.2)
    Signal transduction Regulatory functions DNA interactions heavy metal response regulator (TIGR01387; HMM-score: 58.8)
    and 4 more
    proteobacterial dedicated sortase system response regulator (TIGR03787; HMM-score: 44.7)
    4-hydroxyphenylacetate catabolism regulatory protein HpaA (TIGR02297; HMM-score: 40.7)
    Signal transduction Regulatory functions DNA interactions PEP-CTERM-box response regulator transcription factor (TIGR02915; HMM-score: 33.3)
    Signal transduction Signal transduction Two-component systems TMAO reductase sytem sensor TorS (TIGR02956; EC 2.7.13.3; HMM-score: 31.7)
  • TheSEED: see SPN23F05960
  • PFAM:
    CheY (CL0304) Response_reg; Response regulator receiver domain (PF00072; HMM-score: 103.4)
    and 5 more
    HTH (CL0123) HTH_18; Helix-turn-helix domain (PF12833; HMM-score: 69.8)
    HTH_AraC; Bacterial regulatory helix-turn-helix proteins, AraC family (PF00165; HMM-score: 60.7)
    ArsR; ArsR transcriptional regulator (PF09824; HMM-score: 16.1)
    MazG (CL0231) MazG-like; MazG-like family (PF12643; HMM-score: 14)
    no clan defined DUF5678; Family of unknown function (DUF5678) (PF18929; HMM-score: 14)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004809
    • TAT(Tat/SPI): 0.000455
    • LIPO(Sec/SPII): 0.000516
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000222616 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MTYTILIVEDEYLVRQGLTKLVNVAAYDMEIIGQAENGRQAWELIQKQVPDIILTDINMPHLNGIQLASLVRETYPQVHLVFLTGYDDFDYALSAVKLGVDDYLLKPFSRQDIEEMLGKIKQKLDKEEKEEQLQDLLTNRFEGNMAQKIQSHLADSQFSLKSLASDLGFSPTYLSSLIKKELGLPFQDYLVRERVKQAKLLLLTTDLKIYEIAEKVGFEDMNYFTQRFKQIAGVTPRQFKKGEDR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Clare E Blue, Tim J Mitchell
Contribution of a response regulator to the virulence of Streptococcus pneumoniae is strain dependent.
Infect Immun: 2003, 71(8);4405-13
[PubMed:12874319] [WorldCat.org] [DOI] (P p)Wouter T Hendriksen, Nuno Silva, Hester J Bootsma, Clare E Blue, Gavin K Paterson, Alison R Kerr, Anne de Jong, Oscar P Kuipers, Peter W M Hermans, Tim J Mitchell
Regulation of gene expression in Streptococcus pneumoniae by response regulator 09 is strain dependent.
J Bacteriol: 2007, 189(4);1382-9
[PubMed:17085554] [WorldCat.org] [DOI] (P p)Stephanie Hirschmann, Alejandro Gómez-Mejia, Ulrike Mäder, Julia Karsunke, Dominik Driesch, Manfred Rohde, Susanne Häussler, Gerhard Burchhardt, Sven Hammerschmidt
The Two-Component System 09 Regulates Pneumococcal Carbohydrate Metabolism and Capsule Expression.
Microorganisms: 2021, 9(3);
[PubMed:33668344] [WorldCat.org] [DOI] (P e)Stephanie Hirschmann, Alejandro Gómez-Mejia, Thomas P Kohler, Franziska Voß, Manfred Rohde, Max Brendel, Sven Hammerschmidt
The Two-Component System 09 of Streptococcus pneumoniae Is Important for Metabolic Fitness and Resistance during Dissemination in the Host.
Microorganisms: 2021, 9(7);
[PubMed:34201716] [WorldCat.org] [DOI] (P e)

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