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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ATCC 700669
  • locus tag: SPN23F_RS03065 [old locus tags: SPN23F05990 SPN23F_05990 ]
  • pan locus tag?: PNEUPAN001606000
  • symbol: SPN23F_RS03065
  • pan gene symbol?: zmpB
  • synonym:
  • product: FIVAR domain-containing protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN23F_RS03065 [old locus tags: SPN23F05990 SPN23F_05990 ]
  • symbol: SPN23F_RS03065
  • product: FIVAR domain-containing protein
  • replicon: chromosome
  • strand: +
  • coordinates: 591175..596844
  • length: 5670
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    3061
    3121
    3181
    3241
    3301
    3361
    3421
    3481
    3541
    3601
    3661
    3721
    3781
    3841
    3901
    3961
    4021
    4081
    4141
    4201
    4261
    4321
    4381
    4441
    4501
    4561
    4621
    4681
    4741
    4801
    4861
    4921
    4981
    5041
    5101
    5161
    5221
    5281
    5341
    5401
    5461
    5521
    5581
    5641
    GTGTTTAAAAAAGACCGTTTTTCAATTCGTAAGATTAAGGGAGTTGTAGGCTCTGTATTT
    CTTGGAAGCCTTTTGATGGCTCCTTCTGTAGTGGACGCAGCCACCTATCACTATGTAAAT
    AAAGAGATTATTTCACAAGAAGCTAAAGATTTAATTCAGACAGGAAAGCCTGACAGGAAT
    GAAGTTGTATATGGTTTGGTGTATCAAAAAGATCAGTTGCCTCAAACAGGGACAGAAGCA
    TCTGTTTTGACAGCTTTTGGTTATCTATCAGGTGACATCCTCAAAACGCTTGGCTTGGAC
    ACTGTTTTAGAAGAAACCTCAGCAAAACCTGGAGAGGTGACTGTAGTCGAAGTTGAGACT
    CCTCAATCAACAACAAATCAGGAGCAAGCTAGGACAGAAAACCAAGTAGTAGAGACAGAG
    GAAGCTCCAAAAGAAGAAGCACCTAAAACAGAAGAAAGTCCAAAGGAAGAACCAAAATCG
    GAGATAAAACCTACTGACGACACCCTTCCTAAAGTAGAAGAGGGGAAAGAAGATTCAGCA
    GAACCAGCTCCAGTTGAAGAAGTAGGTGGAGAAGTTGAGTCAAAACCAGAGGAAAAAGTA
    GCAGTTAAGCCAGAAAGTCAACCATCAGACAAACCAACAGAGGAACCAAAAGTTGAACAA
    GTAGGTGAACCAGTCGAGCCAAGTGAAGACGAACAGGCACCAACGGCACCAGTTGAGCCA
    GAAAAGCAACCAGAAGCTCCTGAAGAAGAGAAGGCTGTAGAGGAAACACCGAAACCAGAA
    GATAAAATAAAGGGTATTGGTACTAAAGAACCAGTTGATAAAAGTGAGTTAAATAATCAA
    ATTGATAAAGCTAGTTCAGTTTCTCCTACTGATTATTCTACAGCAAGTTACAATGATCTT
    GGACCTGTTTTAGAAACTGCAAAAGGTGTCTATGCTTCAGAGCCTGTAAAACAGCCTGAG
    GTAAATAGTGAGACAAATAAACTTAAAACGGCTATTGACGCTCTAAACGTTGATAAAACT
    GAATTAAACAATACGATTGCAGATGCAAAAACAAAGGTAAAAGAACATTACAGTGATAGA
    AGTTGGCAAAACCTCCAAACTGGGGTTACAGAAGCTGAAAAAGTTGCAGCTAATACAGAT
    GCTAAACAAAGTGAAGTAAATTCTGAGACTGCAAGTCTTAAAACAGCAATTTCTAGATTA
    AATACAGATAAAGTTGAACTCGAAAATCAACTTAAGATTGCACAGGGAAAAACTGAAACT
    GATTTCAGCATGGAATCTTGGACTGTTTTGAGTACAGCTAAAAATAAAGCTCAGGAAGTA
    AAAGATAACGGAACAGCGACCCAAGAACAAATAAACGAAGCAGAGAAAAGTTTGAAAACA
    GCCCTTGCTGACTTATCTGTTGACAAAACAGCTTTGGGAAGCGCTATCGATACAGCTACT
    AAGAAAAATAAAGAGAATTATACAAATCAAACATGGGCAGAGTTGGAAACAGCGCTTACA
    GCAGCAAAATCTGTAAATACTAACGAGTCTAAACAAAGCGACGTTAACGAAGCTGCTGAA
    AAATTAACTGCAACTATGGAAAAATTGGTTGAATTGTCTGAAAAGCCACGTTTGACTCTA
    TCTATTGAAAAGAGAGACATAGATCGAAAAGCTACGGTCACGTATACTTTGGAAAATCCA
    GCAAATACTCAAATAAAATCAATAACTGCAACTCTGAAAAAAGGAGAGGAAGTTGTTAAG
    GATTTTGTTTTAACAGAAGAAAATCTTAAAACTAATCATTTAACTGCTTTGTTTGAAAAG
    CTAGACTACTACAAAGAATACACTCTATCTACGGATATGGTATATAACAGAGGAAATGAT
    GATGAGACGGAGAGTATTTCAGAAGAACTAATTCAGCTGAATCTTAAGAAACTAGAATTG
    AAAGATATCCAGACAGTCTCTCTGATGAAATTTGAAAATGGTCAAGAAAGTCAGGTTACA
    CACTTGTCTGATAAACCGACCGATTTGAGTAAATTATACTTAAAAGTTACATCATCAACG
    TCTAAGGATGCTGTGTTAGCCGTTAGCTCTATAGAAGAAGAGATTATTGAAAATAAAAAA
    ATCTTTAAAATTCATGCAGATACACCAGAATTAGTAGTTCGTAAGAAAGATGGCAGTCTT
    TCTAAGGGATTTGACTATTACATGGAGAGAGTTATCCCTCATGATGGTGATATTTATTAT
    GATTTTAAAGACTTGATTTCAGCTATGACATCTAATCCTACAGGTACGTTTATTTTAGGG
    AGAGATATTTCCTCGCGTAATGTAAAACCGGATGGAAATGGAAAATCTTATATCAAAGGT
    GAATTTAAAGGAAAACTACTTGGTACAAATGATAATGTTAGACACTCGATTTTTGACTTA
    GAATATCCATTGTTTGATACTATAAAATCAGGAGTCGTGAAAGATATTGATTTCAAGCAT
    GTCAATATGGTATTCCCAGATAGCAATCAAGGAGATAACGTAGCAACAATTGCAAGAGTA
    ATCAAAGATAAGACAAAAATTGAGAATGTTAATGTTGAAGGTTATCTCGAGGGTCGAGAT
    CATGTAGCTGGTTTAGTTAATAATCTTGAAGGTAATTCCGAAATTGAAAATGTATCCTTT
    ACAGGAAAGATTAAGTCTAAAGGTGGTAATTCTATTACAGCAGGTATTGCAGGTAGAAAT
    ATCTTATCTCGTGTTAAACGTGCCTATGTAAATGCAGATATAGAGGTACATCGATCATCT
    AATTCTAGCATGCTTGTTGCAGTAAATGGAATAAATGCAGATGCAAGTGGTGGTTGGGGA
    ACCTGGGGTAGACTTACTGAGTCAGTTGCTAAAGGAACATTAGAAACCAAGCAAGGAGGG
    CAAGCTGGAGGAGCCTCTTCTACAGTCTGGCCTTATGGAGCAATTGATAATGTTGTCAGC
    TATGCAAAAGTGACCAAAGGGAAAGAATTATTTGGATCAGATGGTGATTTAAATTATGAT
    TGGTTTATGAAAAAAATTAGTAATATTTTTGGTGTTCAAGGCATCAGCTCAGGCGATTCG
    GGTAGTGATTCTAAATTTACGCGTATTTCTGAGGAAGAAGCAAATCAAAAAGTTGCTTCT
    TATAATATTACAGCTCCCAACTTGATGAGTGACTCAAGTCTTTTGGTAGACAGACTCAAT
    GAAAGTTGGAAAAATACTGATCAATTTGAAAGTATACAGGATTATCAAGCCCAAAACCAA
    TTAATTTACCAGAACTTGACTAAATTTACTCCTTATTACAATAAAGAATTTATTGTTCAT
    GAAGGAAATGCTCTCACTCCTGAACAGGAAATATTGAAGACTAAGAAAATCAAATCGATT
    GTAGGGTTGAAAGGAACAGAGTTCGTTGTAGATGGCAGTGATATTGATACTATCATGCTT
    CATTTTGAGGATGGTAGTCAGAAGCGATATAAGGTAACCTCTACTGGTAAGTTTTCGATA
    ACTAATTTACCGGAATATCAGGTTGAAGATTTAAATGTGGTGTATACATCAGAACATATA
    GTACATCCACTAGATTCGTCACTGATAAATAACCTTGTTGAAGAATTGAAAAAAGTAGAA
    TTGTATACAGAGTCTACTTACCAAGTTCTAGGTATTGATAAAGATAATGCTAACAAATTG
    AATAGAACTAAGAGATTATTCTTAGATGAGTCATTAGATGCTGTTAAAACACAATTGCCT
    ACCTTTGTAAAAACAATGTTTGAAAATGAGTGGTTGCACATCAATGGAGAATCTAGTGGA
    GCTGTCGCTGCTTTACGACAAAAAATCATGGATAATAAGACGGCTATATTGCTTGCTTTG
    ACTTATATCAATCGTTATTATGATGTTAAATTCTCAGACTATAATATTAAAAAACTGATG
    CTCTTTAAACCAACTTTCCATGGTGAAAAGATTGATCTATTAGATCGATTAATCCGACTA
    GGATCATCTGGAGAAAATAGATTAAAAGGTTCAGAAAATGCAGAAACGTTCAAGCAGTTA
    TTTGCTAGCGAAACGAAGCAGAAGGATTTGGTGACTTATTTAGACTACAATCGCTCTTTG
    TTGACTAATTATCAAACAACAGGGGAATGGTTTAAAGAAACGACTAAGGATTATATTCAA
    TTTGAGGAACGTCCATCCTTAGTAGAGGAGATTAAAGATGCCAAATATCGAGTTTACGAT
    AATTTAACCGCACCGTATTATCAAGGATATATCCTACCTCTCTTAACGTTGAAGAATACT
    CATTTAGCAATTTTATCGAACTATAGTACTATGACATTTGTCAGCCGTGAAAAACGCCCT
    AATTGGAAAAATGAAGATTTTGATAAGTGGGTGAAATATGTAGCAACTGCTCATAGAAAC
    CATGTTGATACTTGGTATAAGATTTTACCTGATAATATCAAAGGTAAAATGGTTAAAGAG
    AATGTTACTGCTGTTTGGGAAGGATTGAGCATCCCAGGAAGTGAATGGGTAGACCAGAAT
    GCTGTAGATAGAAAAGGAAGAGATTACGCCCCAGCTCGAGAATTCTTTAATCTTGTAGGT
    GGTCCTATGGGAGGTTGGTATGCTTACCATGGTTATGGTGCGCATGCTGGAGGAAGAAAT
    CGGGTTAATTATGAGGTGTTTGATGTATTAAGTGAGTATGGTATATCGGTCTTTACTCAT
    GAATTGACTCACGTTAATGATACTTGGATTTACTTAGGAGGGTATGGTAGACGTGAAAAT
    ATGGGACCTGAAGCTTATGCTCAGGGATTATTCCAGTCTCCTGTTCCAGGTCAGCCGGGT
    TGGGGGGCGCTTGGTCTCAATATGGCATTTGAAAGAAAAAATGATGGTGATCTAATTTAT
    AATGCCTCCCCAACTCAATTTGAAAATAGGAAAGAGTTAGATAGTTATATGAAAAATTAT
    AACGATACTCTCATGATGGTGGACTACTTGGAAGGAGATGCAGTTATCTCTAAAGGTAAA
    GAAGCTATTACTAAATGGTTTAAAAAAGTTGAACCTAAGGTTGTTAGTCAAACAGCTCAG
    TATGATACGGTTCGTCAGTTGACTGCTGAAGAGAAAGAAAAACTTTCTGTTTCTAGTGTT
    GATGATTTAGTTGATCAAGGATTAATGTCAGACAGAGCTGTAGGAAATAATACCTATAAT
    CCAGCTGATTTTGAAACAAGTTATATTGCGATAGATTATATGACTGGTATTTATGGTGGA
    GGAAAGAATAGTGTAGGTTCACCAGGTGCCTTGATGTTTAAACATAATACTTTCCGTATG
    TGGGGCTACTATGGTTTTGAAGAAGGTGTTCTAGGATATGCTTCTAATAAATTTAAGCAA
    GCATCTAGAGATGAAGGTCATGCTGGACTTAGTGATAACTTTATTATTTCTAAGATTTCC
    AAAGGGGAATTTTTAACTATGGAAGCATTTAAAAAGGGATATTTTAAGAAAGTAGTAGAA
    GAGTTAAAAACTAAAGGTATTCGTCCTGTTACTATCAATCAAAAAACATATAGCACCTTT
    GAAGAATTGCAAGAAGGATTTAAGCAGGCTGTTGAAAGAGATTTGAAGAAAAATCAGTTA
    GATGAGAGGGAAACAAGAAACTTCAAATTCCAAGTTTTCAGACAACTTCTTCAACAAACA
    GATAGCTTTAAAACTTCTATCTTTAGATAA
    60
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    2160
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    2820
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    3000
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    3180
    3240
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    3420
    3480
    3540
    3600
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    4020
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    4140
    4200
    4260
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    4440
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    4860
    4920
    4980
    5040
    5100
    5160
    5220
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    5340
    5400
    5460
    5520
    5580
    5640
    5670

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN23F_RS03065 [old locus tags: SPN23F05990 SPN23F_05990 ]
  • symbol: SPN23F_RS03065
  • description: FIVAR domain-containing protein
  • length: 1889
  • theoretical pI: 4.90396
  • theoretical MW: 211654
  • GRAVY: -0.629698

⊟Function[edit | edit source]

  • TIGRFAM:
    Cellular processes Cellular processes Cell division chromosome segregation protein SMC (TIGR02168; HMM-score: 1.9)
    Genetic information processing DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02168; HMM-score: 1.9)
  • TheSEED: see SPN23F05990
  • PFAM:
    no clan defined Peptidase_M26_C; M26 IgA1-specific Metallo-endopeptidase C-terminal region (PF07580; HMM-score: 612.7)
    and 5 more
    Peptidase_M26_N; M26 IgA1-specific Metallo-endopeptidase N-terminal region (PF05342; HMM-score: 274.7)
    B_GA (CL0598) FIVAR; FIVAR domain (PF07554; HMM-score: 70.2)
    no clan defined Glug; The GLUG motif (PF07581; HMM-score: 12.9)
    ATP-synt_DE; ATP synthase, Delta/Epsilon chain, long alpha-helix domain (PF00401; HMM-score: 9.8)
    YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 9.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 9.94
    • Extracellular Score: 0.06
    • Internal Helices: 0
  • SignalP: Signal peptide SP(Sec/SPI) length 33 aa
    • SP(Sec/SPI): 0.98483
    • TAT(Tat/SPI): 0.008282
    • LIPO(Sec/SPII): 0.001095
    • Cleavage Site: CS pos: 33-34. VDA-AT. Pr: 0.9782
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000473015 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MFKKDRFSIRKIKGVVGSVFLGSLLMAPSVVDAATYHYVNKEIISQEAKDLIQTGKPDRNEVVYGLVYQKDQLPQTGTEASVLTAFGYLSGDILKTLGLDTVLEETSAKPGEVTVVEVETPQSTTNQEQARTENQVVETEEAPKEEAPKTEESPKEEPKSEIKPTDDTLPKVEEGKEDSAEPAPVEEVGGEVESKPEEKVAVKPESQPSDKPTEEPKVEQVGEPVEPSEDEQAPTAPVEPEKQPEAPEEEKAVEETPKPEDKIKGIGTKEPVDKSELNNQIDKASSVSPTDYSTASYNDLGPVLETAKGVYASEPVKQPEVNSETNKLKTAIDALNVDKTELNNTIADAKTKVKEHYSDRSWQNLQTGVTEAEKVAANTDAKQSEVNSETASLKTAISRLNTDKVELENQLKIAQGKTETDFSMESWTVLSTAKNKAQEVKDNGTATQEQINEAEKSLKTALADLSVDKTALGSAIDTATKKNKENYTNQTWAELETALTAAKSVNTNESKQSDVNEAAEKLTATMEKLVELSEKPRLTLSIEKRDIDRKATVTYTLENPANTQIKSITATLKKGEEVVKDFVLTEENLKTNHLTALFEKLDYYKEYTLSTDMVYNRGNDDETESISEELIQLNLKKLELKDIQTVSLMKFENGQESQVTHLSDKPTDLSKLYLKVTSSTSKDAVLAVSSIEEEIIENKKIFKIHADTPELVVRKKDGSLSKGFDYYMERVIPHDGDIYYDFKDLISAMTSNPTGTFILGRDISSRNVKPDGNGKSYIKGEFKGKLLGTNDNVRHSIFDLEYPLFDTIKSGVVKDIDFKHVNMVFPDSNQGDNVATIARVIKDKTKIENVNVEGYLEGRDHVAGLVNNLEGNSEIENVSFTGKIKSKGGNSITAGIAGRNILSRVKRAYVNADIEVHRSSNSSMLVAVNGINADASGGWGTWGRLTESVAKGTLETKQGGQAGGASSTVWPYGAIDNVVSYAKVTKGKELFGSDGDLNYDWFMKKISNIFGVQGISSGDSGSDSKFTRISEEEANQKVASYNITAPNLMSDSSLLVDRLNESWKNTDQFESIQDYQAQNQLIYQNLTKFTPYYNKEFIVHEGNALTPEQEILKTKKIKSIVGLKGTEFVVDGSDIDTIMLHFEDGSQKRYKVTSTGKFSITNLPEYQVEDLNVVYTSEHIVHPLDSSLINNLVEELKKVELYTESTYQVLGIDKDNANKLNRTKRLFLDESLDAVKTQLPTFVKTMFENEWLHINGESSGAVAALRQKIMDNKTAILLALTYINRYYDVKFSDYNIKKLMLFKPTFHGEKIDLLDRLIRLGSSGENRLKGSENAETFKQLFASETKQKDLVTYLDYNRSLLTNYQTTGEWFKETTKDYIQFEERPSLVEEIKDAKYRVYDNLTAPYYQGYILPLLTLKNTHLAILSNYSTMTFVSREKRPNWKNEDFDKWVKYVATAHRNHVDTWYKILPDNIKGKMVKENVTAVWEGLSIPGSEWVDQNAVDRKGRDYAPAREFFNLVGGPMGGWYAYHGYGAHAGGRNRVNYEVFDVLSEYGISVFTHELTHVNDTWIYLGGYGRRENMGPEAYAQGLFQSPVPGQPGWGALGLNMAFERKNDGDLIYNASPTQFENRKELDSYMKNYNDTLMMVDYLEGDAVISKGKEAITKWFKKVEPKVVSQTAQYDTVRQLTAEEKEKLSVSSVDDLVDQGLMSDRAVGNNTYNPADFETSYIAIDYMTGIYGGGKNSVGSPGALMFKHNTFRMWGYYGFEEGVLGYASNKFKQASRDEGHAGLSDNFIISKISKGEFLTMEAFKKGYFKKVVEELKTKGIRPVTINQKTYSTFEELQEGFKQAVERDLKKNQLDERETRNFKFQVFRQLLQQTDSFKTSIFR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Damiana Chiavolini, Guido Memmi, Tiziana Maggi, Francesco Iannelli, Gianni Pozzi, Marco R Oggioni
The three extra-cellular zinc metalloproteinases of Streptococcus pneumoniae have a different impact on virulence in mice.
BMC Microbiol: 2003, 3;14
[PubMed:12841855] [WorldCat.org] [DOI] (I e)C E Blue, G K Paterson, A R Kerr, M Bergé, J P Claverys, T J Mitchell
ZmpB, a novel virulence factor of Streptococcus pneumoniae that induces tumor necrosis factor alpha production in the respiratory tract.
Infect Immun: 2003, 71(9);4925-35
[PubMed:12933834] [WorldCat.org] [DOI] (P p)

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