PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 11-FEB-2025

⊟Summary

• organism: Streptococcus pneumoniae ATCC 700669
• locus tag: SPN23F_RS06785 [old locus tags: SPN23F13420 SPN23F_13420 ]
• pan locus tag^?: PNEUPAN002652000
• symbol: SPN23F_RS06785
• pan gene symbol^?: aroE
• synonym:
• product: shikimate dehydrogenase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPN23F_RS06785 [old locus tags: SPN23F13420 SPN23F_13420 ]
• symbol: SPN23F_RS06785
• product: shikimate dehydrogenase
• replicon: chromosome
• strand: -
• coordinates: 1312967..1313821
• length: 855
• essential: unknown

⊟Accession numbers

• Location: NC_011900 (1312967..1313821) NCBI
• BioCyc: SPN23F_RS06785 BioCyc
• MicrobesOnline: see SPN23F13420
• PneumoBrowse for strain D39V: SPV_1210 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  
  ATGAAGCTTGATGGCTATACACGTTTAGCTGCAGTTGTTGCCAATCCTATTAAGCATTCT
  ATTTCTCCCTTCATCCACAATAGAGCCTTTGAGGCGACAGCTACCAACGGTGCTTATGTG
  GCTTGGGAGATTGAAGCGAGTGACTTGGCAGAAACAGTGGCCAATATTCGTCGCTACCAG
  ATGTTTGGCATCAATCTGTCCATGCCCTATAAGGAGCAGGTGATTCCTTATTTGGATAAG
  CTGAGCGATGAAGCGCGCTTGATTGGTGCGGTTAATACGGTTGTCAATGAGAATGGCAAT
  TTAATTGGATATAATACAGATGGCAAGGGATTTTTTAAGTGCTTGCCTTCTTTTACAATT
  TCAGGTAAAAAGATGACCCTGCTGGGTGCAGGTGGTGCGGCTAAATCAATCTTGGCACAG
  GCTATTTTGGATGGCGTCAGTCAGATTTCGGTCTTTGTTCGTTCAGTTTCTATGGAAAAA
  ACAAGACCTTACCTAGACAAGTTACAGGAGCAAACAGGCTTTAAAGTGGACTTGTATGCT
  TTAGAAAATGTTTCTGAACTGCAAGCAAGGATTGTCGAGTCGGATTTACTGGTCAATGCC
  ACCAGTGTGGGCATGGATGGTCAATCATCCCCAGTTCCTGAAAGCATCAATTTGCCAGAA
  ACTATCTTGGTGGCAGATATTATTTATCAACCCTTTGAAACGCCATTTTTAAAATGGGCC
  AGAAGTCAGGGCAAACCAGCGGTTAATGGTCTGGGAATGTTGCTCTATCAAGCTGCAGAA
  GCTTTTCAACTGTGGACAGGCAAGGAAATGCCAACAGAAGAGATTTGGCAGTCTTTAACA
  GAAAAATACCAATAA
  60
  120
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  840
  855
  

⊟Protein

⊟General

• locus tag: SPN23F_RS06785 [old locus tags: SPN23F13420 SPN23F_13420 ]
• symbol: SPN23F_RS06785
• description: shikimate dehydrogenase
• length: 284
• theoretical pI: 4.86662
• theoretical MW: 31282.6
• GRAVY: -0.0588028

⊟Function

• reaction:
  EC 1.1.1.25?  ExPASy
  Shikimate dehydrogenase Shikimate + NADP⁺ = 3-dehydroshikimate + NADPH
• TIGRFAM:
  Metabolism Amino acid biosynthesis Aromatic amino acid family shikimate dehydrogenase (TIGR00507; EC 1.1.1.25; HMM-score: 238)
  and 3 more
  Metabolism Amino acid biosynthesis Aromatic amino acid family shikimate-5-dehydrogenase (TIGR01809; EC 1.1.1.25; HMM-score: 116.9)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin glutamyl-tRNA reductase (TIGR01035; EC 1.2.1.70; HMM-score: 12.6)
  Genetic information processing Protein synthesis Ribosomal proteins: synthesis and modification ribosomal protein uS11 (TIGR03632; HMM-score: 12.3)
• TheSEED: see SPN23F13420
• PFAM:
  AA_dh_N (CL0603) Shikimate_dh_N; Shikimate dehydrogenase substrate binding domain (PF08501; HMM-score: 97)
  and 3 more
  no clan defined SDH_C; Shikimate 5'-dehydrogenase C-terminal domain (PF18317; HMM-score: 50.9)
  NADP_Rossmann (CL0063) Shikimate_DH; Shikimate / quinate 5-dehydrogenase (PF01488; HMM-score: 19.9)
  P-loop_NTPase (CL0023) TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 13.8)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9973
  • Cytoplasmic Membrane Score: 0.0004
  • Cell wall & surface Score: 0.0001
  • Extracellular Score: 0.0023
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.019743
  • TAT(Tat/SPI): 0.002814
  • LIPO(Sec/SPII): 0.001642
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000762476 NCBI
• UniProt: see SPN23F13420

⊟Protein sequence

• MKLDGYTRLAAVVANPIKHSISPFIHNRAFEATATNGAYVAWEIEASDLAETVANIRRYQMFGINLSMPYKEQVIPYLDKLSDEARLIGAVNTVVNENGNLIGYNTDGKGFFKCLPSFTISGKKMTLLGAGGAAKSILAQAILDGVSQISVFVRSVSMEKTRPYLDKLQEQTGFKVDLYALENVSELQARIVESDLLVNATSVGMDGQSSPVPESINLPETILVADIIYQPFETPFLKWARSQGKPAVNGLGMLLYQAAEAFQLWTGKEMPTEEIWQSLTEKYQ

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: psr < pheA < SPN23F_RS06755 < aroA < SPN23F_RS06765 < SPN23F_RS06770 < aroC < aroB < SPN23F_RS06785 < aroD < SPN23F_RS06795

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V: SPV_1210 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications