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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 14-DEC-2023

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPNA45
  • locus tag: SPNA45_RS04710 [old locus tag: SPNA45_00826 ]
  • pan locus tag?: PNEUPAN002652000
  • symbol: SPNA45_RS04710
  • pan gene symbol?: aroE
  • synonym:
  • product: shikimate dehydrogenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNA45_RS04710 [old locus tag: SPNA45_00826 ]
  • symbol: SPNA45_RS04710
  • product: shikimate dehydrogenase
  • replicon: chromosome
  • strand: +
  • coordinates: 822027..822881
  • length: 855
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_018594 (822027..822881) NCBI
  • BioCyc: SPNA45_RS04710 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1210 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGAAGCTTGATGGCTATACACGTTTAGCTGCAGTTGTTGCCAATCCTATTAAGCATTCT
    ATTTCTCCCTTCATCCACAATAGAGCCTTTGAGGCGACAGCTACCAACGGTGCTTATGTG
    GCTTGGGAGATTGAAGCGAGTGACTTGGTAGAAACAGTGGCCAATATTCGTCGCTACCAG
    ATGTTTGGCATCAATCTGTCCATGCCCTATAAGGAGCAGGTGATTCCTTATTTGGATAAG
    CTGAGCGATGAAGCGCGCTTGATTGGTGCGGTTAATACGGTTGTCAATGAGAATGGCAAT
    TTAATTGGATATAATACAGATGGCAAGGGATTTTTTAAGTGCTTGCCTTCTTTTACAATT
    TCAGGTAAAAAGATGACCCTGCTGGGTGCAGGTGGTGCGGCTAAATCAATCTTGGCACAG
    GCTATTTTGGATGGCGTCAGTCAGATTTCGGTCTTTGTTCGTTCCGTTTCTATGGAAAAA
    ACAAGACCTTACCTAGACAAGTTACAGGAGCAGACAGGTTTTAAAGTGGATTTGTGTGCT
    TTAGAATATGTTTCTGAACTGCAAGCAAGGATTGCCGAGTCGGATTTGCTAGTTAATGCC
    ACCAGTGTGGGCATGGATGGCCAATCCTCTCCTGTTCCTGAAAACATAGTCTTACCAGAA
    ACTCTTTTAGTTGCAGATATCATATACCAATCCTTTGAAACACCGTTTTTGAAATGGGCT
    AGAAGTCAGGGCAATCCAGCAGTCAATGGTCTGGGAATGTTACTCTATCAAGCTGCAGAA
    GCTTTTCAACTGTGGACAGGCAAGGAAATGCCGACAGAAGAGATTTGGCAGTCTTTAACA
    GAAAAATACCAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    855

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNA45_RS04710 [old locus tag: SPNA45_00826 ]
  • symbol: SPNA45_RS04710
  • description: shikimate dehydrogenase
  • length: 284
  • theoretical pI: 4.75513
  • theoretical MW: 31259.6
  • GRAVY: -0.0183099

⊟Function[edit | edit source]

  • reaction:
    EC 1.1.1.25?  ExPASy
    Shikimate dehydrogenase Shikimate + NADP+ = 3-dehydroshikimate + NADPH
  • TIGRFAM:
    Metabolism Amino acid biosynthesis Aromatic amino acid family shikimate dehydrogenase (TIGR00507; EC 1.1.1.25; HMM-score: 234.8)
    and 3 more
    Metabolism Amino acid biosynthesis Aromatic amino acid family shikimate-5-dehydrogenase (TIGR01809; EC 1.1.1.25; HMM-score: 119.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin glutamyl-tRNA reductase (TIGR01035; EC 1.2.1.70; HMM-score: 15.1)
    Genetic information processing Protein synthesis Ribosomal proteins: synthesis and modification ribosomal protein uS11 (TIGR03632; HMM-score: 12.3)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    AA_dh_N (CL0603) Shikimate_dh_N; Shikimate dehydrogenase substrate binding domain (PF08501; HMM-score: 95.8)
    and 3 more
    no clan defined SDH_C; Shikimate 5'-dehydrogenase C-terminal domain (PF18317; HMM-score: 51)
    NADP_Rossmann (CL0063) Shikimate_DH; Shikimate / quinate 5-dehydrogenase (PF01488; HMM-score: 20.3)
    no clan defined DUF3600; Domain of unknown function (DUF3600) (PF12207; HMM-score: 11.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9971
    • Cytoplasmic Membrane Score: 0.0006
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0022
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.018141
    • TAT(Tat/SPI): 0.002353
    • LIPO(Sec/SPII): 0.001603
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000762486 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKLDGYTRLAAVVANPIKHSISPFIHNRAFEATATNGAYVAWEIEASDLVETVANIRRYQMFGINLSMPYKEQVIPYLDKLSDEARLIGAVNTVVNENGNLIGYNTDGKGFFKCLPSFTISGKKMTLLGAGGAAKSILAQAILDGVSQISVFVRSVSMEKTRPYLDKLQEQTGFKVDLCALEYVSELQARIAESDLLVNATSVGMDGQSSPVPENIVLPETLLVADIIYQSFETPFLKWARSQGNPAVNGLGMLLYQAAEAFQLWTGKEMPTEEIWQSLTEKYQ

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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