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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN994038
  • locus tag: SPN994038_RS10795 [old locus tag: SPN994038_19560 ]
  • pan locus tag?: PNEUPAN003928000
  • symbol: pgsA
  • pan gene symbol?: pgsA
  • synonym:
  • product: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN994038_RS10795 [old locus tag: SPN994038_19560 ]
  • symbol: pgsA
  • product: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
  • replicon: chromosome
  • strand: -
  • coordinates: 2005731..2006276
  • length: 546
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_021026 (2005731..2006276) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_2049 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    ATGAAAAAAGAACAAATTCCCAATCTCTTAACAATAGGTCGAATTCTCTTTATACCTATT
    TTTCTCTTTATTTTAACGATAGGAAATTCGATAGAGAGTCATATAGTTGCAGCTATTATC
    TTTGCTGTTGCCAGTATTACCGACTATTTAGATGGATATTTAGCTCGTAAATGGAATGTG
    GTCAGTAATTTTGGTAAATTTGCAGATCCTATGGCGGATAAGTTACTAGTTATGTCGGCT
    TTTATTATGTTGATTGAGTTAGGTATGGCTCCGGCTTGGATTGTTGCAGTGATTATCTGT
    CGTGAGTTAGCTGTGACAGGTTTAAGGCTTTTATTGGTTGAAACTGGTGGAACAATTTTA
    GCAGCAGCAATGCCTGGAAAAATTAAAACTTTTAGTCAGATGTTTGCCATTATTTTCTTG
    CTATTACATTGGACTTTGCTTGGTCAAGTTCTACTTTATGTAGCCTTATTTTTCACTATC
    TACTCTGGCTATGACTATTTCAAGGGTAGTGCCTATGTATTTAAAGGGACATTTGGTTCG
    AAATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    546

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN994038_RS10795 [old locus tag: SPN994038_19560 ]
  • symbol: PgsA
  • description: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
  • length: 181
  • theoretical pI: 9.57474
  • theoretical MW: 20057
  • GRAVY: 0.950829

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.8.5?  ExPASy
    CDP-diacylglycerol--glycerol-3-phosphate 1-phosphatidyltransferase CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate
  • TIGRFAM:
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (TIGR00560; EC 2.7.8.5; HMM-score: 177.5)
    and 2 more
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis CDP-diacylglycerol-serine O-phosphatidyltransferase (TIGR00473; EC 2.7.8.8; HMM-score: 31.3)
    archaetidylserine synthase (TIGR04217; EC 2.7.8.-; HMM-score: 25.3)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    no clan defined CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase (PF01066; HMM-score: 151.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 5
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.9996
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0004
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.328719
    • TAT(Tat/SPI): 0.001525
    • LIPO(Sec/SPII): 0.031912
  • predicted transmembrane helices (TMHMM): 5

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000712141 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKKEQIPNLLTIGRILFIPIFLFILTIGNSIESHIVAAIIFAVASITDYLDGYLARKWNVVSNFGKFADPMADKLLVMSAFIMLIELGMAPAWIVAVIICRELAVTGLRLLLVETGGTILAAAMPGKIKTFSQMFAIIFLLLHWTLLGQVLLYVALFFTIYSGYDYFKGSAYVFKGTFGSK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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