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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 05-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN994039
  • locus tag: SPN994039_RS00060 [old locus tag: SPN994039_00120 ]
  • pan locus tag?: PNEUPAN000367000
  • symbol: hpt
  • pan gene symbol?: hpt
  • synonym:
  • product: hypoxanthine phosphoribosyltransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN994039_RS00060 [old locus tag: SPN994039_00120 ]
  • symbol: hpt
  • product: hypoxanthine phosphoribosyltransferase
  • replicon: chromosome
  • strand: +
  • coordinates: 11801..12343
  • length: 543
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_021005 (11801..12343) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0012 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    ATGTTAGAAAACGATATTAAAAAAGTCCTCGTTTCACACGATGAAATTACAGAAGCAGCT
    AAAAAACTAGGTGCTCAATTAACTAAAGACTATGCAGGAAAAAATCCAATCTTAGTTGGG
    ATTTTAAAAGGATCTATTCCTTTTATGGCTGAATTGGTCAAACATATTGATACACATATT
    GAAATGGACTTCATGATGGTTTCTAGCTACCATGGTGGAACAGCAAGTAGTGGTGTTATC
    AATATTAAACAAGATGTGACTCAAGATATCAAAGGAAGACATGTTCTATTTGTAGAAGAT
    ATCATTGATACAGGTCAAACTTTGAAGAATTTGCGAGATATGTTTAAAGAAAGAGAAGCA
    GCTTCTGTTAAAATTGCAACCTTGTTGGATAAACCAGAAGGACGTGTTGTAGAAATTGAG
    GCAGACTATACCTGCTTTACTATCCCAAATGAGTTTGTAGTAGGTTATGGTTTAGACTAC
    AAAGAAAATTATCGTAATCTTCCTTATATTGGAGTATTGAAAGAGGAAGTGTATTCAAAT
    TAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    543

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN994039_RS00060 [old locus tag: SPN994039_00120 ]
  • symbol: Hpt
  • description: hypoxanthine phosphoribosyltransferase
  • length: 180
  • theoretical pI: 5.09473
  • theoretical MW: 20212.1
  • GRAVY: -0.183333

⊟Function[edit | edit source]

  • reaction:
    EC 2.4.2.8?  ExPASy
    Hypoxanthine phosphoribosyltransferase IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides hypoxanthine phosphoribosyltransferase (TIGR01203; EC 2.4.2.8; HMM-score: 214.8)
    and 8 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides uracil phosphoribosyltransferase (TIGR01091; EC 2.4.2.9; HMM-score: 28.9)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis ribose-phosphate diphosphokinase (TIGR01251; EC 2.7.6.1; HMM-score: 26.4)
    Cellular processes Cellular processes DNA transformation comF family protein (TIGR00201; HMM-score: 20.3)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis orotate phosphoribosyltransferase (TIGR01367; EC 2.4.2.10; HMM-score: 18)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides adenine phosphoribosyltransferase (TIGR01090; EC 2.4.2.7; HMM-score: 17.3)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis pur operon repressor PurR (TIGR01743; HMM-score: 16.8)
    Signal transduction Regulatory functions DNA interactions pur operon repressor PurR (TIGR01743; HMM-score: 16.8)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis orotate phosphoribosyltransferase (TIGR00336; EC 2.4.2.10; HMM-score: 16.2)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    PRTase-like (CL0533) Pribosyltran; Phosphoribosyl transferase domain (PF00156; HMM-score: 106.6)
    and 4 more
    EDD (CL0245) EIIA-man; PTS system fructose IIA component (PF03610; HMM-score: 15.5)
    PRTase-like (CL0533) PRTase_2; Phosphoribosyl transferase (PF15609; HMM-score: 13.4)
    UPRTase; Uracil phosphoribosyltransferase (PF14681; HMM-score: 13)
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain (PF14572; HMM-score: 12.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9927
    • Cytoplasmic Membrane Score: 0.0001
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0071
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002476
    • TAT(Tat/SPI): 0.000194
    • LIPO(Sec/SPII): 0.000543
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000892185 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MLENDIKKVLVSHDEITEAAKKLGAQLTKDYAGKNPILVGILKGSIPFMAELVKHIDTHIEMDFMMVSSYHGGTASSGVINIKQDVTQDIKGRHVLFVEDIIDTGQTLKNLRDMFKEREAASVKIATLLDKPEGRVVEIEADYTCFTIPNEFVVGYGLDYKENYRNLPYIGVLKEEVYSN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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