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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 27-FEB-2015

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPNA45
  • locus tag: SPNA45_00255 [new locus tag: SPNA45_RS01540 ]
  • pan locus tag?: PNEUPAN003591000
  • symbol: rpoB
  • pan gene symbol?: rpoB
  • synonym:
  • product: DNA-directed RNA polymerase beta chain

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNA45_00255 [new locus tag: SPNA45_RS01540 ]
  • symbol: rpoB
  • product: DNA-directed RNA polymerase beta chain
  • replicon: chromosome
  • strand: +
  • coordinates: 264482..267910
  • length: 3429
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    3061
    3121
    3181
    3241
    3301
    3361
    3421
    ATGGAGTTGGAATTTGTTGGATATGAAATCAAGGAACCAAAATACACGCTAGAAGAAGCT
    CGTATCCACGATGCTAGCTACTCAGCACCAATTTTTGTAACCTTCCGCTTGATCAATAAA
    GAAACAGGCGAAATCAAGACCCAAGAAGTTTTCTTTGGTGATTTCCCAATCATGACAGAA
    ATGGGTACTTTCATCATCAATGGTGGTGAACGTATTATCGTTTCTCAGTTGGTCCGCTCA
    CCAGGTGTTTACTTTAACGACAAAGTAGACAAAAATGGTAAGGTGGGCTATGGTTCAACT
    GTTATCCCTAACCGTGGAGCTTGGCTGGAACTTGAAAGCGACTCAAAAGATATCACCTAC
    ACTCGTATCGACCGTACTCGTAAGATTCCATTTACAACCTTGGTTCGTGCTCTTGGTTTC
    TCAGGTGATGATGAAATCTTTGATATTTTTGGTGACAGCGAATTGGTTCGCAACACTGTT
    GAAAAAGATATCCACAAGAATCCAATGGACTCTCGTACAGACGAAGCCTTGAAAGAAATT
    TACGAACGCCTTCGTCCAGGTGAGCCTAAGACGGCTGAAAGCTCACGTAGCTTGCTTGTG
    GCTCGCTTCTTTGACCCACGTCGCTATGACTTGGCAGCAGTTGGTCGTTACAAAATCAAT
    AAAAAACTCAATGTTAAAACACGTTTGCTCAACCAAACCATTGCAGAGCCATTGGTAGAC
    CCTGAAACTGGAGAAATCTTGGTAGAAGCTGGTACGATTATGACTCGTAGCGTGATTGAA
    AGCATTGAAAGCCATTTGGATGGCGACTTGAACAAGATTGTCTACATCCCAAACGATGCA
    GCCGTTGTGACTGAGCCTGTTGTTCTTCAAAAATTCAAGGTTGTTGCTCCAACTGATCCA
    GATCGCGTCGTAACGATCATTGGTAATGCTAACCCAGATGATAAGGTTCGTACGGTGACT
    CCTGCAGATATCCTTGCTGAGATGAGCTACTTCCTCAACTTGGCTGAAGGACTTGGCCGT
    GTAGATGATATCGACCACCTTGGAAATCGTCGTATCCGTGCGGTTGGTGAATTGCTTGCT
    AACCAAGTACGTTTGGGACTTTCTCGTATGGAACGTAATGTCCGTGAACGTATGTCTGTT
    CAGGACAATGAAGTCTTGACACCACAACAAATTATCAATATTCGTCCTGTAACAGCTGCA
    GTTAAAGAATTCTTTGGTTCATCACAGTTGTCACAGTTCATGGACCAACACAACCCGCTT
    TCTGAGTTGTCTCACAAACGCCGTTTGTCAGCCTTAGGACCTGGTGGTTTGACTCGTGAC
    CGTGCCGGATATGAAGTACGTGACGTGCACTACACTCACTATGGTCGTATGTGTCCAATC
    GAGACACCTGAAGGACCTAACATCGGTTTGATCAATAACTTGTCATCTTACGGACACTTG
    AACAAATATGGTTTTGTTCAAACACCATACCGTAAGGTTGACCGTGAAACAGGTGTTGTC
    ACGAACGAAATTGTTTGGTTGACAGCTGATGAAGAAGATGAATATACTGTAGCTCAGGCT
    AACTCTCGTCTGAATGAAGATGGAACCTTTGCTGAGAAGATTGTCATGGGACGTCACCAA
    GGGGTCAACCAAGAGTATCCAGCTAATATTGTTGACTACATGGACGTTTCACCAAAACAG
    GTAGTTGCCGTTGCGACAGCATGTATTCCTTTCTTGGAAAACGATGACTCCAACCGTGCC
    CTCATGGGAGCCAATATGCAACGTCAGGCTGTGCCATTGATTAATCCTCAGGCACCTTAC
    GTTGGTACTGGTATGGAATACCAAGCAGCCCACGATTCTGGTGCGGCTGTGATTGCTCAG
    TATGATGGTAAAGTTACTTACGCAGATGCTGACAAGGTAGAAGTTCGTCGTGAAGATGGT
    TCATTGGATGTTTACCACATCCAAAAATTCCGTCGTTCAAACTCAGGTACTGCTTACAAC
    CAACGCACTCTCGTAAAAGTTGGTGATGTCGTTGAAAAAGGCGATTTCATCGCTGACGGG
    CCTTCTATGGAAAATGGAGAAATGGCGCTTGGACAAAACCCAATCGTTGCCTACATGACT
    TGGGAAGGTTACAACTTCGAGGATGCCGTTATCATGAGCGAACGCTTGGTGAAGGACGAT
    GTCTACACATCTGTTCACCTTGAAGAATACGAATCAGAAACGCGCGATACAAAGCTTGGG
    CCTGAAGAAATCACTCGCGAAATTCCAAACGTTGGTGAAGATGCCCTCAAAGACCTTGAC
    GAAATGGGGATTATCCGTATTGGTGCTGAGGTTAAAGAAGGTGATATTCTTGTAGGTAAA
    GTAACACCTAAGGGTGAGAAAGACCTTTCAGCTGAAGAACGTCTCTTGCACGCTATCTTT
    GGAGACAAGTCTCGTGAAGTGCGTGATACTTCTCTTCGTGTACCACACGGTGCCGATGGT
    GTCGTTCGTGATGTTAAGATCTTTACACGTGTAAATGGAGATGAGTTGCAATCAGGTGTT
    AACATGTTGGTTCGTGTTTACATCGCTCAAAAACGTAAGATTAAGGTCGGAGATAAAATG
    GCCGGACGTCACGGAAACAAAGGGGTTGTCTCTCGTATCGTTCCTGTAGAAGACATGCCT
    TACCTTCCAGACGGAACTCCAGTCGACATCATGTTGAACCCACTTGGGGTGCCATCACGT
    ATGAATATCGGTCAGGTTATGGAGCTTCACCTTGGTATGGCAGCTCGTACTCTTGGTATT
    CACATTGCGACACCAGTCTTTGATGGAGCAAGTTCTGAAGATCTTTGGTCAACTGTTAAA
    GAAGCAGGTATGGATAGCGATGCCAAGACAATCCTTTACGATGGACGTACAGGTGAACCA
    TTTGATAACCGTGTTTCTGTTGGAGTCATGTACATGATCAAACTCCACCACATGGTTGAC
    GATAAATTGCACGCGCGTTCAGTCGGACCTTACTCAACTGTTACCCAACAACCACTCGGA
    GGTAAAGCTCAGTTTGGTGGACAACGTTTCGGTGAGATGGAGGTTTGGGCTCTTGAAGCC
    TACGGTGCGTCAAATGTCCTTCAAGAAATCTTGACTTACAAGTCGGACGATATCAACGGA
    CGTTTGAAAGCCTATGAAGCTATTACAAAAGGCAAACCAATTCCAAAACCAGGTGTTCCA
    GAATCCTTCCGAGTTCTTGTCAAAGAATTGCAATCTCTTGGTCTTGACATGCGTGTCCTA
    GACGAAGATGACCAAGAAGTGGAACTTCGCGACTTGGATGAAGGAATGGACGAAGATGTC
    ATCCACGTAGATGACCTTGAAAAAGCCCGCGAAAAAGCAGCCCAAGAGGCTAAAGCAGCC
    TTTGAAGCTGAAGAAGCTGAGAAAGCAACAAAAGCGGAAGCAACAGAAGAAGCTGCTGAA
    CAAGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2700
    2760
    2820
    2880
    2940
    3000
    3060
    3120
    3180
    3240
    3300
    3360
    3420
    3429

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNA45_00255 [new locus tag: SPNA45_RS01540 ]
  • symbol: RpoB
  • description: DNA-directed RNA polymerase beta chain
  • length: 1142
  • theoretical pI: 4.71804
  • theoretical MW: 127258
  • GRAVY: -0.416813

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Transcription DNA-dependent RNA polymerase DNA-directed RNA polymerase, beta subunit (TIGR02013; EC 2.7.7.6; HMM-score: 1641.4)
    and 2 more
    DNA-directed RNA polymerase subunit B (TIGR03670; EC 2.7.7.6; HMM-score: 295.2)
    Genetic information processing Transcription DNA-dependent RNA polymerase DNA-directed RNA polymerase, beta' subunit (TIGR02386; EC 2.7.7.6; HMM-score: 13.7)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    LEF-8-like (CL0410) RNA_pol_Rpb2_6; RNA polymerase Rpb2, domain 6 (PF00562; HMM-score: 539.5)
    and 8 more
    no clan defined RNA_pol_Rpb2_2; RNA polymerase Rpb2, domain 2 (PF04561; HMM-score: 117.5)
    RNA_pol_Rpb2_3; RNA polymerase Rpb2, domain 3 (PF04565; HMM-score: 97)
    RNA_pol_Rpb2_7; RNA polymerase Rpb2, domain 7 (PF04560; HMM-score: 90.7)
    RNA_pol_Rpb2_1; RNA polymerase beta subunit (PF04563; HMM-score: 81.4)
    RNA_pol_Rpb2_45; RNA polymerase beta subunit external 1 domain (PF10385; HMM-score: 79.8)
    Hybrid (CL0105) Peptidase_M23; Peptidase family M23 (PF01551; HMM-score: 19.3)
    no clan defined NusG_add; NusG additional domain (PF18298; HMM-score: 14.9)
    Hybrid (CL0105) Biotin_lipoyl_2; Biotin-lipoyl like (PF13533; HMM-score: 12.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003678
    • TAT(Tat/SPI): 0.000119
    • LIPO(Sec/SPII): 0.000429
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: CCM07545 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MELEFVGYEIKEPKYTLEEARIHDASYSAPIFVTFRLINKETGEIKTQEVFFGDFPIMTEMGTFIINGGERIIVSQLVRSPGVYFNDKVDKNGKVGYGSTVIPNRGAWLELESDSKDITYTRIDRTRKIPFTTLVRALGFSGDDEIFDIFGDSELVRNTVEKDIHKNPMDSRTDEALKEIYERLRPGEPKTAESSRSLLVARFFDPRRYDLAAVGRYKINKKLNVKTRLLNQTIAEPLVDPETGEILVEAGTIMTRSVIESIESHLDGDLNKIVYIPNDAAVVTEPVVLQKFKVVAPTDPDRVVTIIGNANPDDKVRTVTPADILAEMSYFLNLAEGLGRVDDIDHLGNRRIRAVGELLANQVRLGLSRMERNVRERMSVQDNEVLTPQQIINIRPVTAAVKEFFGSSQLSQFMDQHNPLSELSHKRRLSALGPGGLTRDRAGYEVRDVHYTHYGRMCPIETPEGPNIGLINNLSSYGHLNKYGFVQTPYRKVDRETGVVTNEIVWLTADEEDEYTVAQANSRLNEDGTFAEKIVMGRHQGVNQEYPANIVDYMDVSPKQVVAVATACIPFLENDDSNRALMGANMQRQAVPLINPQAPYVGTGMEYQAAHDSGAAVIAQYDGKVTYADADKVEVRREDGSLDVYHIQKFRRSNSGTAYNQRTLVKVGDVVEKGDFIADGPSMENGEMALGQNPIVAYMTWEGYNFEDAVIMSERLVKDDVYTSVHLEEYESETRDTKLGPEEITREIPNVGEDALKDLDEMGIIRIGAEVKEGDILVGKVTPKGEKDLSAEERLLHAIFGDKSREVRDTSLRVPHGADGVVRDVKIFTRVNGDELQSGVNMLVRVYIAQKRKIKVGDKMAGRHGNKGVVSRIVPVEDMPYLPDGTPVDIMLNPLGVPSRMNIGQVMELHLGMAARTLGIHIATPVFDGASSEDLWSTVKEAGMDSDAKTILYDGRTGEPFDNRVSVGVMYMIKLHHMVDDKLHARSVGPYSTVTQQPLGGKAQFGGQRFGEMEVWALEAYGASNVLQEILTYKSDDINGRLKAYEAITKGKPIPKPGVPESFRVLVKELQSLGLDMRVLDEDDQEVELRDLDEGMDEDVIHVDDLEKAREKAAQEAKAAFEAEEAEKATKAEATEEAAEQE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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