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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_1961 [new locus tag: SP_RS09855 ]
  • pan locus tag?: PNEUPAN003591000
  • symbol: rpoB
  • pan gene symbol?: rpoB
  • synonym:
  • product: DNA-directed RNA polymerase, beta subunit

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_1961 [new locus tag: SP_RS09855 ]
  • symbol: rpoB
  • product: DNA-directed RNA polymerase, beta subunit
  • replicon: chromosome
  • strand: -
  • coordinates: 1866355..1869966
  • length: 3612
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    3061
    3121
    3181
    3241
    3301
    3361
    3421
    3481
    3541
    3601
    TTGGCAGGACATGACGTTCAATACGGGAAACATCGTACCCGTCGTAGTTTTTCAAGAATC
    AAAGAAGTTCTTGACTTACCAAATTTGATTGAAATTCAAACTGACTCATTCAAAGCTTTC
    CTAGACCACGGTCTTAAGGAAGTGTTTGAAGATGTATTGCCAATTTCAAACTTCACAGAC
    ACAATGGAGTTGGAATTTGTTGGATATGAAATCAAGGAACCAAAATATACGCTAGAAGAA
    GCTCGTATCCACGATGCTAGCTACTCAGCACCAATTTTTGTAACCTTCCGTTTGATCAAT
    AAAGAAACAAGCGAAATCAAGACCCAAGAAGTTTTCTTTGGTGATTTCCCAATCATGACA
    GAAATGGGTACTTTCATCATCAATGGTGGTGAACGTATTATCGTTTCTCAGTTGGTCCGC
    TCACCAGGTGTTTACTTTAACGACAAAGTAGACAAAAATGGTAAGGTGGGCTATGGTTCA
    ACTGTTATCCCTAACCGTGGAGCTTGGTTGGAACTTGAAAGCGACTCAAAAGATATCACC
    TACACTCGTATCGACCGTACTCGTAAGATTCCATTTACAACCTTGGTTCGTGCTCTTGGT
    TTCTCAGGTGATGATGAAATCTTTGATATCTTTGGTGACAGCGAATTGGTTCGCAACACT
    GTTGAAAAAGATATCCACAAGAATCCAATGGACTCTCGTACAGACGAAGCCTTGAAAGAA
    ATTTACGAACGCCTTCGTCCAGGTGAGCCTAAGACGGCTGAAAGCTCACGTAGCTTGCTT
    GTAGCTCGCTTCTTTGACCCACGTCGTTATGACTTGGCAGCAGTTGGTCGTTACAAAATC
    AATAAAAAACTCAATGTTAAAACACGTTTGCTCAACCAAACCATTGCAGAGCCATTGGTA
    GACCCTGAAACTGGAGAAATCTTGGTAGAAGCTGGTACGATTATGACTCGTAGCGTGATT
    GAAAGCATTGAAAGCCATTTGGATGGCGACTTGAACAAGATTGTCTACATCCCAAACGAT
    GCAGCCGTTGTGACTGAGCCTGTTGTTCTTCAAAAATTCAAGGTTATTGCTCCAACTGAT
    CCAGATCGCGTCGTAACGATCATTGGTAATGCTAACCCAGATGACAAGGTTCGTACGGTG
    ACTCCTGCAGATATCCTTGCTGAGATGAGCTACTTCCTCAACTTGGCTGAAGGACTTGGC
    CGTGTAGATGATATCGACCACCTTGGAAATCGTCGTATCCGTGCGGTTGGTGAATTGCTT
    GCCAACCAAGTACGTTTGGGACTTTCTCGTATGGAACGTAATGTCCGTGAACGTATGTCT
    GTTCAGGACAATGAAGTCTTGACACCACAACAAATTATCAATATCCGTCCTGTAACAGCT
    GCAGTTAAAGAATTCTTTGGTTCATCACAGTTGTCACAGTTCATGGACCAACACAACCCG
    CTTTCTGAGTTGTCTCACAAACGCCGTTTGTCAGCCTTAGGACCTGGTGGTTTGACTCGT
    GACCGTGCTGGATATGAAGTACGTGACGTGCACTACACTCACTATGGTCGTATGTGTCCA
    ATCGAGACACCTGAAGGACCTAACATCGGTTTGATCAATAACTTGTCATCTTATGGACAC
    TTGAACAAATATGGTTTTGTTCAAACACCATACCGTAAGGTTGACCGTGAAACAGGTGTT
    GTCACGAACGAAATTGTTTGGTTGACAGCTGATGAAGAAGATGAATATACTGTAGCTCAG
    GCTAACTCTCGTCTGAATGAAGATGGAACCTTTGCTGAGAAGATTGTCATGGGACGTCAC
    CAAGGGGTCAACCAAGAGTATCCAGCTAATATTGTTGACTACATGGACGTTTCACCAAAA
    CAGGTAGTTGCCGTTGCGACAGCATGTATTCCTTTCTTGGAAAACGATGACTCCAACCGT
    GCCCTCATGGGAGCCAATATGCAACGTCAGGCTGTGCCATTGATTAATCCTCAGGCACCT
    TACGTTGGTACTGGTATGGAATACCAAGCAGCCCACGATTCTGGTGCGGCTGTGATTGCT
    CAGTATGATGGTAAAGTTACTTACGCAGATGCTGACAAGGTAGAAGTTCGTCGTGAAGAT
    GGTTCATTGGATGTTTACCACATCCAAAAATTCCGTCGTTCAAACTCAGGTACTGCTTAC
    AACCAACGCACTCTCGTAAAAGTTGGTGATGTCGTTGAAAAAGGCGATTTCATCGCTGAC
    GGACCTTCTATGGAAAATGGAGAAATGGCGCTTGGACAAAACCCAATCGTTGCCTACATG
    ACTTGGGAAGGTTACAACTTCGAGGATGCCGTTATCATGAGCGAACGCTTGGTGAAGGAC
    GATGTCTACACATCTGTTCACCTTGAAGAATACGAATCAGAAACGCGCGATACAAAGCTT
    GGGCCTGAAGAAATCACTCGCGAAATTCCAAACGTTGGTGAAGATGCCCTCAAAGACCTT
    GACGAAATGGGGATTATCCGTATTGGTGCTGAGGTTAAAGAAGGTGATATTCTTGTAGGT
    AAAGTAACACCTAAGGGTGAGAAAGATCTTTCAGCTGAAGAACGTCTCTTGCACGCTATC
    TTTGGAGACAAGTCTCGTGAAGTGCGTGATACTTCTCTTCGTGTACCACACGGTGCCGAT
    GGTGTCGTTCGTGATGTTAAGATCTTTACACGTGTAAATGGAGATGAGTTGCAATCAGGT
    GTTAACATGTTGGTTCGTGTTTACATCGCTCAAAAACGTAAGATTAAGGTCGGAGATAAA
    ATGGCCGGACGTCACGGAAACAAAGGGGTTGTCTCTCGTATCGTTCCTGTAGAAGACATG
    CCTTACCTTCCAGACGGAACTCCAGTCGACATCATGTTGAACCCACTTGGGGTACCATCA
    CGTATGAATATCGGTCAGGTTATGGAGCTTCACCTTGGTATGGCAGCTCGTACTCTTGGT
    ATTCACATCGCTACACCAGTCTTTGATGGAGCAAGTTCTGAAGATCTTTGGTCAACTGTT
    AAAGAAGCAGGTATGGATAGCGATGCCAAAACGATCCTTTACGATGGACGTACTGGTGAA
    CCGTTTGATAACCGTGTTTCTGTCGGAGTCATGTACATGATCAAACTCCACCACATGGTT
    GATGATAAATTGCACGCGCGTTCAGTCGGACCATACTCAACTGTTACCCAACAACCACTC
    GGAGGTAAGGCTCAGTTTGGTGGACAACGTTTCGGTGAGATGGAGGTTTGGGCTCTTGAA
    GCCTACGGTGCGTCAAATGTCCTTCAAGAAATCTTGACTTACAAGTCGGACGATATCAAC
    GGACGTTTGAAAGCCTATGAAGCTATTACAAAAGGCAAACCAATTCCAAAACCAGGTGTT
    CCAGAATCCTTCCGAGTTCTTGTCAAAGAATTGCAATCTCTTGGTCTTGACATGCGTGTC
    CTAGACGAAGATGACCAAGAAGTGGAACTTCGCGACTTGGATGAAGGAATGGACGAAGAT
    GTCATCCACGTAGATGACCTTGAAAAAGCCCGCGAAAAAGCAGCCCAAGAGGCTAAAGCA
    GCCTTTGAAGCTGAAGAAGCTGAGAAAGCAACAAAAGCGGAAGCAACAGAAGAAGCTGCT
    GAACAAGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2700
    2760
    2820
    2880
    2940
    3000
    3060
    3120
    3180
    3240
    3300
    3360
    3420
    3480
    3540
    3600
    3612

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_1961 [new locus tag: SP_RS09855 ]
  • symbol: RpoB
  • description: DNA-directed RNA polymerase, beta subunit
  • length: 1203
  • theoretical pI: 4.75871
  • theoretical MW: 134361
  • GRAVY: -0.418038

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.7.6?  ExPASy
    DNA-directed RNA polymerase Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
  • TIGRFAM:
    Genetic information processing Transcription DNA-dependent RNA polymerase DNA-directed RNA polymerase, beta subunit (TIGR02013; EC 2.7.7.6; HMM-score: 1693.9)
    and 2 more
    DNA-directed RNA polymerase subunit B (TIGR03670; EC 2.7.7.6; HMM-score: 294.7)
    Genetic information processing Transcription DNA-dependent RNA polymerase DNA-directed RNA polymerase, beta' subunit (TIGR02386; EC 2.7.7.6; HMM-score: 13.5)
  • TheSEED  :
    • DNA-directed RNA polymerase beta subunit (EC 2.7.7.6)
    RNA Metabolism Transcription RNA polymerase bacterial  DNA-directed RNA polymerase beta subunit (EC 2.7.7.6)
    and 1 more
    Virulence Virulence - no subcategory Mycobacterium virulence operon involved in DNA transcription  DNA-directed RNA polymerase beta subunit (EC 2.7.7.6)
  • PFAM:
    LEF-8-like (CL0410) RNA_pol_Rpb2_6; RNA polymerase Rpb2, domain 6 (PF00562; HMM-score: 539.3)
    and 8 more
    no clan defined RNA_pol_Rpb2_2; RNA polymerase Rpb2, domain 2 (PF04561; HMM-score: 117.4)
    RNA_pol_Rpb2_1; RNA polymerase beta subunit (PF04563; HMM-score: 97.5)
    RNA_pol_Rpb2_3; RNA polymerase Rpb2, domain 3 (PF04565; HMM-score: 96.9)
    RNA_pol_Rpb2_7; RNA polymerase Rpb2, domain 7 (PF04560; HMM-score: 90.6)
    RNA_pol_Rpb2_45; RNA polymerase beta subunit external 1 domain (PF10385; HMM-score: 79.6)
    Hybrid (CL0105) Peptidase_M23; Peptidase family M23 (PF01551; HMM-score: 19.2)
    no clan defined NusG_add; NusG additional domain (PF18298; HMM-score: 14.7)
    Hybrid (CL0105) Biotin_lipoyl_2; Biotin-lipoyl like (PF13533; HMM-score: 12.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001252
    • TAT(Tat/SPI): 0.000141
    • LIPO(Sec/SPII): 0.000182
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MAGHDVQYGKHRTRRSFSRIKEVLDLPNLIEIQTDSFKAFLDHGLKEVFEDVLPISNFTDTMELEFVGYEIKEPKYTLEEARIHDASYSAPIFVTFRLINKETSEIKTQEVFFGDFPIMTEMGTFIINGGERIIVSQLVRSPGVYFNDKVDKNGKVGYGSTVIPNRGAWLELESDSKDITYTRIDRTRKIPFTTLVRALGFSGDDEIFDIFGDSELVRNTVEKDIHKNPMDSRTDEALKEIYERLRPGEPKTAESSRSLLVARFFDPRRYDLAAVGRYKINKKLNVKTRLLNQTIAEPLVDPETGEILVEAGTIMTRSVIESIESHLDGDLNKIVYIPNDAAVVTEPVVLQKFKVIAPTDPDRVVTIIGNANPDDKVRTVTPADILAEMSYFLNLAEGLGRVDDIDHLGNRRIRAVGELLANQVRLGLSRMERNVRERMSVQDNEVLTPQQIINIRPVTAAVKEFFGSSQLSQFMDQHNPLSELSHKRRLSALGPGGLTRDRAGYEVRDVHYTHYGRMCPIETPEGPNIGLINNLSSYGHLNKYGFVQTPYRKVDRETGVVTNEIVWLTADEEDEYTVAQANSRLNEDGTFAEKIVMGRHQGVNQEYPANIVDYMDVSPKQVVAVATACIPFLENDDSNRALMGANMQRQAVPLINPQAPYVGTGMEYQAAHDSGAAVIAQYDGKVTYADADKVEVRREDGSLDVYHIQKFRRSNSGTAYNQRTLVKVGDVVEKGDFIADGPSMENGEMALGQNPIVAYMTWEGYNFEDAVIMSERLVKDDVYTSVHLEEYESETRDTKLGPEEITREIPNVGEDALKDLDEMGIIRIGAEVKEGDILVGKVTPKGEKDLSAEERLLHAIFGDKSREVRDTSLRVPHGADGVVRDVKIFTRVNGDELQSGVNMLVRVYIAQKRKIKVGDKMAGRHGNKGVVSRIVPVEDMPYLPDGTPVDIMLNPLGVPSRMNIGQVMELHLGMAARTLGIHIATPVFDGASSEDLWSTVKEAGMDSDAKTILYDGRTGEPFDNRVSVGVMYMIKLHHMVDDKLHARSVGPYSTVTQQPLGGKAQFGGQRFGEMEVWALEAYGASNVLQEILTYKSDDINGRLKAYEAITKGKPIPKPGVPESFRVLVKELQSLGLDMRVLDEDDQEVELRDLDEGMDEDVIHVDDLEKAREKAAQEAKAAFEAEEAEKATKAEATEEAAEQE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CodY (activation (repression)) regulon
    CodY(TF)important in Amino acid metabolism; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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