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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_1960 [new locus tag: SP_RS09850 ]
  • pan locus tag?: PNEUPAN003592000
  • symbol: rpoC
  • pan gene symbol?: rpoC
  • synonym:
  • product: DNA-directed RNA polymerase, beta' subunit

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_1960 [new locus tag: SP_RS09850 ]
  • symbol: rpoC
  • product: DNA-directed RNA polymerase, beta' subunit
  • replicon: chromosome
  • strand: -
  • coordinates: 1862645..1866322
  • length: 3678
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    3061
    3121
    3181
    3241
    3301
    3361
    3421
    3481
    3541
    3601
    3661
    GTGGTTGATGTAAATCGTTTTAAAAGTATGCAAATCACCCTAGCTTCTCCAAGTAAAGTC
    CGTTCATGGTCTTATGGAGAAGTCAAAAAACCTGAAACAATCAATTATCGTACCTTGAAA
    CCAGAACGTGAAGGACTCTTTGATGAAGTGATCTTTGGTCCTACAAAAGACTGGGAATGT
    GCTTGTGGTAAGTACAAACGCATTCGTTACAGAGGAATTGTTTGTGACCGCTGTGGGGTT
    GAAGTAACGCGTACGAAAGTTCGTCGTGAGCGTATGGGACATATCGAATTGAAAGCTCCT
    GTATCTCACATCTGGTACTTCAAGGGGATTCCAAGCCGTATGGGCTTGACCCTTGATATG
    AGCCCTCGTGCCCTCGAGGAAGTTATCTACTTTGCGGCTTATGTGGTGATTGATCCTAAG
    GATACACCACTTGAGCACAAGTCTATCATGACAGAGCGCGAATACCGAGAGCGCTTGCGT
    GAATATGGTTATGGTTCATTTGTTGCCAAGATGGGTGCGGAAGCCATCCAAGACCTTTTG
    AAGCAAGTAGATCTTGAAAAAGAAATTGCTGAACTCAAAGAAGAATTGAAAACAGCTACT
    GGACAAAAGCGTGTCAAAGCCATCCGTCGTTTGGATGTTTTGGATGCCTTTTACAAGTCT
    GGAAACAAACCTGAATGGATGATTCTTAACATCCTTCCGGTTATCCCACCAGATCTTCGT
    CCAATGTTGCAGTTGGATGGTGGCCGTTTTGCCTCATCTGACTTGAATGACCTTTACCGC
    CGTGTTATCAACCGTAACAACCGTTTGGCTCGTTTGCTTGAGTTAAATGCACCAGGTATC
    ATCGTTCAAAATGAGAAGCGTATGCTTCAAGAAGCAGTTGACGCTTTGATTGACAATGGT
    CGTCGTGGTCGTCCAATCACAGGACCAGGTAGCCGTCCATTGAAATCATTGAGCCACATG
    CTTAAAGGTAAACAAGGACGCTTCCGTCAAAACTTGCTCGGTAAACGTGTTGACTTCTCA
    GGACGTTCAGTTATCGCCGTTGGTCCAACTCTTAAGATGTACCAATGTGGTGTGCCGCGT
    GAAATGGCGATTGAACTCTTTAAACCATTTGTCATGCGTGAAATCGTTGCCCGTGATATC
    GTGCAAAACGTCAAAGCAGCTAAACGCTTGGTGGAACGCGGAGATGAGCGTATCTGGGAT
    ATCCTTGAAGAAGTGATTAAAGAACACCCAGTGCTTTTGAACCGCGCACCGACCCTTCAC
    CGTTTGGGTATCCAAGCCTTCGAGCCAGTCTTGATTGATGGTAAGGCTCTTCGCTTGCAC
    CCACTTGTCTGTGAAGCCTACAATGCTGACTTTGACGGGGACCAAATGGCCATCCACGTA
    CCACTTTCAGAAGAAGCACAAGCAGAAGCTCGTATCCTCATGCTAGCTGCTGAGCACATC
    TTGAACCCGAAAGATGGGAAACCGGTAGTTACTCCATCTCAGGACATGGTTTTGGGTAAC
    TACTACTTGACCATGGAAGAAGCTGGTCGCGAAGGTGAAGGAATGGTCTTCAAAGACCGT
    GACGAAGCGGTTATGGCTTACCGCAATGGTTATGTTCACCTCCACTCACGTGTTGGTATC
    GCAACAGACAGCCTCAACAAGCCTTGGACAGAAGAGCAAAGACATAAGGTCTTGCTTACA
    ACAGTTGGTAAAATTCTCTTCAACGATATCATGCCAGAGGGGCTACCATACTTGCAAGAA
    CCAAACAATGCCAACTTGACAGAAGGTGTTCCAGCTAAATACTTCTTGCCACTTGGTGGA
    GATATCAAGGAAGCTATCAGCAATCTTGAGCTCAACCCTCCATTCAAGAAGAAAAACCTT
    GGAAATATCATCGCTGAAATCTTCAAACGTTTCCGTACGACAGAAACTTCTGCCCTACTT
    GACCGCATGAAGAACCTCGGTTACCACCACTCAACTCTTGCAGGATTGACAGTGGGTATT
    GCCGATATCCCAGTCGTTGATGACAAGGCTGAAATCATTGAAGAATCACACAAACGTGTC
    GAACAAATCACCAAACAATTCCGTCGTGGTATGATCACAGACGACGAGCGTTACAATGCT
    GTTACAGCTGAATGGCGTGCTGCCCGTGAAAAACTTGAGAAACGCTTGATTGCTAACCAA
    GATCCTAAGAACCCAATCGTTATGATGATGGACTCTGGAGCCCGTGGTAACATCTCAAAC
    TTCTCACAGCTTGCCGGTATGCGTGGTCTGATGGCTGCTCCGAATGGACGTATCATGGAA
    TTGCCAATCCTTTCAAACTTCCGCGAAGGTTTGTCGGTATTGGAAATGTTCTTCTCAACT
    CACGGTGCTCGTAAAGGTATGACCGATACGGCCCTTAAGACAGCCGACTCAGGTTACTTG
    ACTCGTCGTTTGGTCGACGTTGCCCAAGACGTTATCATCCGTGAGGACGACTGTGGAACT
    GACCGTGGTCTCTTGATCCGTTCTATCGCAGAAGGAAAAGAGATGATCGAGTCTCTCGAA
    GAGCGTCTCAACGGTCGTTACACTAAGAAAACTGTTAAACATCCAGAAACTGGTGCAGTG
    ATTATTGGTCCAAATGAATTGATTACAGAAGACAAGGCGCGTGAAATTGTCAATGCTGGT
    GTGGAAGAAGTGACTATCCGTTCTGTATTTACATGTAACACTCGTCACGGTGTCTGCCGT
    CACTGTTACGGTATCAACTTGGCGACTGGTGATGCGGTTGAAGTTGGTGAAGCAGTTGGT
    ACAATCGCTGCCCAATCTATCGGGGAACCTGGTACACAGCTTACAATGCGTACCTTCCAC
    ACAGGTGGGGTTGCCTCAAATACCGATATCACTCAGGGTCTTCCTCGTGTCCAAGAAATC
    TTTGAAGCCCGCAATCCTAAAGGGGAAGCGGTTATTACAGAGGTTAAAGGACAAGTTACT
    GCTATCGAAGAAGATGCATCAACTCGTACCAAGAAAGTCTTTGTTAAGGGTGAAACTGGC
    GAAGGTGAATATGTCGTTCCATTTACAGCTCGTATGCGTGTCGAAGTTGGGGGCCAAGTA
    GCGCGTGGTGCTGCTCTGACAGAAGGTTCTATCCAACCAAAACGTCTCCTTGCAGTTCGT
    GATGTCTTGTCAGTTGAAACGTACCTTCTCGGTGAAGTACAAAAAGTTTACCGTAGCCAA
    GGGGTAGAAATCGGTGACAAACACATCGAGGTAATGGTTCGTCAAATGATCCGTAAAGTC
    CGTGTCATGGATCCAGGTGATACAGATCTTCTCATGGGTACCCTCATGGATATCAATGAC
    TTTACAGATGCCAACAAAGATGTCCTTATCGCAGGTGGAGTTCCAGCGACAGGTCGCCCA
    GTCCTTATGGGAATTACCAAAGCCTCACTTGAAACAAACAGTTTCTTGTCAGCGGCTTCC
    TTCCAGGAAACAACTCGTGTCCTTACTGACGCAGCTATCCGTGGTAAGAAAGACCATCTC
    CTTGGACTTAAAGAAAATGTTATCATCGGTAAGATCATCCCAGCTGGTACTGGTATGGCC
    CGTTACCGTAACCTTGAACCACATGCTGTCAACGAAGAAGAATACCTTAATCCTCCAGTA
    GAGGAAGAAGGAAATGAAGAAACAACAGAAGTAGTTGTGGATACTGCCGTTGAAACTGTG
    GAAGAAACAGTAGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2700
    2760
    2820
    2880
    2940
    3000
    3060
    3120
    3180
    3240
    3300
    3360
    3420
    3480
    3540
    3600
    3660
    3678

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_1960 [new locus tag: SP_RS09850 ]
  • symbol: RpoC
  • description: DNA-directed RNA polymerase, beta' subunit
  • length: 1225
  • theoretical pI: 7.03255
  • theoretical MW: 136988
  • GRAVY: -0.328571

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.7.6?  ExPASy
    DNA-directed RNA polymerase Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
  • TIGRFAM:
    Genetic information processing Transcription DNA-dependent RNA polymerase DNA-directed RNA polymerase, beta' subunit (TIGR02386; EC 2.7.7.6; HMM-score: 1822.1)
    and 4 more
    DNA-directed RNA polymerase, gamma subunit (TIGR02387; EC 2.7.7.6; HMM-score: 831.3)
    Genetic information processing Transcription DNA-dependent RNA polymerase DNA-directed RNA polymerase, beta subunit (TIGR02388; EC 2.7.7.6; HMM-score: 629.6)
    DNA-directed RNA polymerase subunit A' (TIGR02390; EC 2.7.7.6; HMM-score: 325.2)
    Genetic information processing Transcription DNA-dependent RNA polymerase DNA-directed RNA polymerase, subunit A (TIGR02389; EC 2.7.7.6; HMM-score: 105.5)
  • TheSEED  :
    • DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6)
    RNA Metabolism Transcription RNA polymerase bacterial  DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6)
    and 1 more
    Virulence Virulence - no subcategory Mycobacterium virulence operon involved in DNA transcription  DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6)
  • PFAM:
    no clan defined RNA_pol_Rpb1_1; RNA polymerase Rpb1, domain 1 (PF04997; HMM-score: 291.8)
    and 6 more
    RNA_pol_Rpb1_5; RNA polymerase Rpb1, domain 5 (PF04998; HMM-score: 217.8)
    RNA_pol_Rpb1_2; RNA polymerase Rpb1, domain 2 (PF00623; HMM-score: 139.5)
    RNA_pol_Rpb1_3; RNA polymerase Rpb1, domain 3 (PF04983; HMM-score: 112.6)
    RNA_pol_Rpb1_4; RNA polymerase Rpb1, domain 4 (PF05000; HMM-score: 52.9)
    Hybrid (CL0105) Peptidase_M23; Peptidase family M23 (PF01551; HMM-score: 14.5)
    Glyco_hydro_tim (CL0058) Dehydratase_LU; Dehydratase large subunit (PF02286; HMM-score: 12.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.059482
    • TAT(Tat/SPI): 0.007097
    • LIPO(Sec/SPII): 0.008438
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MVDVNRFKSMQITLASPSKVRSWSYGEVKKPETINYRTLKPEREGLFDEVIFGPTKDWECACGKYKRIRYRGIVCDRCGVEVTRTKVRRERMGHIELKAPVSHIWYFKGIPSRMGLTLDMSPRALEEVIYFAAYVVIDPKDTPLEHKSIMTEREYRERLREYGYGSFVAKMGAEAIQDLLKQVDLEKEIAELKEELKTATGQKRVKAIRRLDVLDAFYKSGNKPEWMILNILPVIPPDLRPMLQLDGGRFASSDLNDLYRRVINRNNRLARLLELNAPGIIVQNEKRMLQEAVDALIDNGRRGRPITGPGSRPLKSLSHMLKGKQGRFRQNLLGKRVDFSGRSVIAVGPTLKMYQCGVPREMAIELFKPFVMREIVARDIVQNVKAAKRLVERGDERIWDILEEVIKEHPVLLNRAPTLHRLGIQAFEPVLIDGKALRLHPLVCEAYNADFDGDQMAIHVPLSEEAQAEARILMLAAEHILNPKDGKPVVTPSQDMVLGNYYLTMEEAGREGEGMVFKDRDEAVMAYRNGYVHLHSRVGIATDSLNKPWTEEQRHKVLLTTVGKILFNDIMPEGLPYLQEPNNANLTEGVPAKYFLPLGGDIKEAISNLELNPPFKKKNLGNIIAEIFKRFRTTETSALLDRMKNLGYHHSTLAGLTVGIADIPVVDDKAEIIEESHKRVEQITKQFRRGMITDDERYNAVTAEWRAAREKLEKRLIANQDPKNPIVMMMDSGARGNISNFSQLAGMRGLMAAPNGRIMELPILSNFREGLSVLEMFFSTHGARKGMTDTALKTADSGYLTRRLVDVAQDVIIREDDCGTDRGLLIRSIAEGKEMIESLEERLNGRYTKKTVKHPETGAVIIGPNELITEDKAREIVNAGVEEVTIRSVFTCNTRHGVCRHCYGINLATGDAVEVGEAVGTIAAQSIGEPGTQLTMRTFHTGGVASNTDITQGLPRVQEIFEARNPKGEAVITEVKGQVTAIEEDASTRTKKVFVKGETGEGEYVVPFTARMRVEVGGQVARGAALTEGSIQPKRLLAVRDVLSVETYLLGEVQKVYRSQGVEIGDKHIEVMVRQMIRKVRVMDPGDTDLLMGTLMDINDFTDANKDVLIAGGVPATGRPVLMGITKASLETNSFLSAASFQETTRVLTDAAIRGKKDHLLGLKENVIIGKIIPAGTGMARYRNLEPHAVNEEEYLNPPVEEEGNEETTEVVVDTAVETVEETVE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CodY (activation (repression)) regulon
    CodY(TF)important in Amino acid metabolism; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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