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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 27-FEB-2015

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPNA45
  • locus tag: SPNA45_00613 [new locus tag: SPNA45_RS03540 ]
  • pan locus tag?: PNEUPAN003005000
  • symbol: SPNA45_00613
  • pan gene symbol?: recP-1
  • synonym: tkt
  • product: Transketolase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNA45_00613 [new locus tag: SPNA45_RS03540 ]
  • symbol: SPNA45_00613
  • product: Transketolase
  • replicon: chromosome
  • strand: +
  • coordinates: 615791..617281
  • length: 1491
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: HE983624 (615791..617281) NCBI
  • BioCyc: see SPNA45_RS03540
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    GTGTCTGCGGAGGCGGCTTCTTATGCAGGTCATCAAGCTTTAGATAAGCTTATCGTCCTC
    TACGACTCCAACGACATCTGCTTGGATGGTGAGACCAAAGATACTTTCTCTGAAAATGTT
    CGCGCCCGTTACGATGCTTATGGTTGGCATACAGTTCTGGTAGAAGATGGAACAGATTTA
    GCAGCAATTTCTACAGCAATTGAGACGGCCAAGTTTTCTGGTAAGCCGAGTTTGATTGAA
    GTGAAAACGGTAATTGGTTACGGCTCACCCAATAAAAGTGGTACAAATGCTGTTCATGGT
    GCACCACTAGGAGCAGAAGAAACAGGAGCAACTCGTAAGTTTTTGGGATGGGATTACGAT
    CCATTTGAAGTACCAGAGGAAGTATATTCTGATTTCAAGACAAATGTAGCGGATCGTGGT
    CAGGAGGCATACGATGCTTGGGCTAGTTTGGTGTCTGATTACAAGGTTGCTTATCCCGAA
    GTTGCTAGTGAGATTGACGCTATTGTAGCTGGAAAATCCCCTGTAACCATTACTGAAAAA
    GACTTCCCTGTCTATGAGAATGCCTTCTCTCAAGCAACTCGTAATTCGTCCCAAGATGCT
    ATTAATACAGCAGCAGCAGTTTTACCAACCTTCTTAGGTGGATCGGCAGACTTAGCTCAC
    TCCAACATGACCTACATCAAGGCAGATGGCTTACAAGATAAATATAATCCATTAAACCGC
    AATATTCAGTTTGGGGTACGTGAATTTGCCATGGGAACAATCCTCAATGGAATGGCTCTT
    CATGGTGGTTTACGAGTTTATGGCGGAACCTTCTTTGTTTTCTCTGACTACGTCAAAGCT
    GCTATTCGGCTATCAGCCATTCAGGAGTTGCCTGTAACTTATGTCTTTACCCATGATTCA
    ATTGCCGTTGGTGAAGATGGTCCAACTCATGAACCAGTTGAACATTTGGCAGGTTTACGC
    TCAATGCCAAACTTGACTGTTATCCGTCCAGCGGATGCCCGTGAAACTCAAGCGGCTTGG
    CATCATGCCTTGACCAGTACCACCACTCCAACTGTCATTGTCTTAACCCGTCAAAACTTG
    GTAGTTGAAGAAGGGACAGACTTTGGTAAGGTCGCTAAAGGAGCCTACGTCGTGTATGAT
    ACCCCGGGATTTGATACTATTATCATTGCTACAGGATCTGAGGTCAATCTAGCTATCAAA
    GCTGCTAAGGAATTGGTTTTACAAGGTGGTAAAGTACGTGTGGTATCTATGCCCTCAACC
    GAACTATTTGATGCTCAAGATGCTACCTACAAGGAAGACATTTTACCATCTAAGACTCGT
    CGTCGTGTGGCCATTGAAATGGCAGCGGCCCAAAGTTGGTACAAGTATGTTGGTTTGGAT
    GGCGCGGTCATCGGTATTGACATCTTCGGTGCGTCTGCCCCAGCTCAGACTGTGATTGAT
    AATTATGGATTTACGGTAGAGAATATCGTTGCTCAAGTTAAGTCCCTATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1491

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNA45_00613 [new locus tag: SPNA45_RS03540 ]
  • symbol: SPNA45_00613
  • description: Transketolase
  • length: 496
  • theoretical pI: 4.58583
  • theoretical MW: 53472.6
  • GRAVY: -0.0802419

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Energy metabolism Pentose phosphate pathway transketolase (TIGR00232; EC 2.2.1.1; HMM-score: 624.8)
    and 3 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other 1-deoxy-D-xylulose-5-phosphate synthase (TIGR00204; EC 2.2.1.7; HMM-score: 52.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine 1-deoxy-D-xylulose-5-phosphate synthase (TIGR00204; EC 2.2.1.7; HMM-score: 52.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridoxine 1-deoxy-D-xylulose-5-phosphate synthase (TIGR00204; EC 2.2.1.7; HMM-score: 52.9)
  • TheSEED: data available for Hungary19A-6, TIGR4
  • PFAM:
    THDP-binding (CL0254) Transketolase_N; Transketolase, thiamine diphosphate binding domain (PF00456; HMM-score: 212.9)
    and 2 more
    Transket_pyr; Transketolase, pyrimidine binding domain (PF02779; HMM-score: 152.6)
    TKC_like (CL0591) Transketolase_C; Transketolase, C-terminal domain (PF02780; HMM-score: 59.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.014298
    • TAT(Tat/SPI): 0.000172
    • LIPO(Sec/SPII): 0.005016
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: CCM07901 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSAEAASYAGHQALDKLIVLYDSNDICLDGETKDTFSENVRARYDAYGWHTVLVEDGTDLAAISTAIETAKFSGKPSLIEVKTVIGYGSPNKSGTNAVHGAPLGAEETGATRKFLGWDYDPFEVPEEVYSDFKTNVADRGQEAYDAWASLVSDYKVAYPEVASEIDAIVAGKSPVTITEKDFPVYENAFSQATRNSSQDAINTAAAVLPTFLGGSADLAHSNMTYIKADGLQDKYNPLNRNIQFGVREFAMGTILNGMALHGGLRVYGGTFFVFSDYVKAAIRLSAIQELPVTYVFTHDSIAVGEDGPTHEPVEHLAGLRSMPNLTVIRPADARETQAAWHHALTSTTTPTVIVLTRQNLVVEEGTDFGKVAKGAYVVYDTPGFDTIIIATGSEVNLAIKAAKELVLQGGKVRVVSMPSTELFDAQDATYKEDILPSKTRRRVAIEMAAAQSWYKYVGLDGAVIGIDIFGASAPAQTVIDNYGFTVENIVAQVKSL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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