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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_1615 [new locus tag: SP_RS07965 ]
  • pan locus tag?: PNEUPAN003005000
  • symbol: recP-1
  • pan gene symbol?: recP-1
  • synonym: tkt
  • product: transketolase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_1615 [new locus tag: SP_RS07965 ]
  • symbol: recP-1
  • product: transketolase
  • replicon: chromosome
  • strand: -
  • coordinates: 1515589..1517556
  • length: 1968
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    ATGTCACTACAATCAGTTAACGCCATTCGTTTTCTTGGCGTAGATGCTATTAACAAATCT
    AATTCTGGTCACCCGGGAATTGTCATGGGTGCTGCGCCAATGGCTTATAGCCTATTTACA
    AAGCACCTTAGAATTACACCTGAGCAGCCAAACTGGATTAACCGAGATCGCTTTATCTTG
    TCTGCGGGTCATGGATCAATGCTACTGTATGCTCTCTTGCATTTAACAGGGTATAAGGAT
    GTATCCATGGACGAGATTAAAAATTTCCGGCAATGGGGATCTAAGACACCTGGTCATCCT
    GAAGTGACGCATACGTCTGGTGTGGATGCGACATCTGGTCCGCTTGGTCAGGGGATTTCT
    ACTGCCGTTGGTTTCGCCCAAGCAGAGCGTTTTTTAGCTGCTAAGTACAACAAAGATGGT
    TTCCCTATTTTTGACCATTATACTTATGTTATCGCTGGAGACGGTGACTTCATGGAAGGA
    GTGTCTGCGGAGGCGGCTTCTTATGCAGGTCATCAAGCTTTAGATAAGCTTATCGTCCTC
    TACGACTCCAACGACATCTGCTTGGATGGTGAGACCAAAGATACTTTCTCTGAAAATGTT
    CGCGTCCGTTACGATGCTTATGGTTGGCATACAGTTCTGGTAGAAGATGGAACAGATTTA
    GCAGCAATTTCTACAGCAATTGAGACGGCCAAGTTTTCTGGTAAACCGAGTTTGATTGAA
    GTGAAAACGGTAATTGGTTACGGCTCACCCAATAAAAGTGGTACAAATGCTGTTCATGGT
    GCACCACTAGGAGCAGAAGAAACAGGAGCAACTCGTAAGTTTTTGGGATGGGATTACGAT
    CCATTTGAAGTACCAGAGGAAGTATATTCTGATTTCAAGACAAATGTAGCGGATCGTGGT
    CAGGAGGCATACGATGCTTGGGCTAGTTTGGTGTCTGATTACAAGGTTGCTTATCCCGAA
    GTTGCTAGTGAGATTGACGCTATTGTAGCTGGAAAATCCCCTGTAACCATTACTGAAAAA
    GACTTCCCTGTCTATGAGAATGGCTTCTCTCAAGCAACTCGTAATTCGTCCCAAGATGCT
    ATTAATACAGCAGCAGTTTTACCAACCTTCTTAGGTGGATCGGCAGACTTAGCTCACTCT
    AACATGACCTACATCAAGGCAGATGGCTTACAAGATAAATATAATCCATTAAACCGCAAT
    ATTCAGTTTGGGGTACGTGAATTTGCCATGGGAACAATCCTCAATGGAATGGCTCTTCAT
    GGTGGTTTACGAGTTTATGGCGGAACCTTCTTTGTTTTCTCTGACTACGTCAAAGCTGCT
    ATTCGGCTATCAGCCATTCAGGAGTTGCCTGTAACTTATGTCTTTACCCATGATTCAATT
    GCCGTTGGTGAAGATGGTCCAACTCATGAACCAGTTGAACATTTGGCAGGTTTACGCTCA
    ATGCCAAACTTGACTGTTATCCGTCCAGCGGATGCCCGTGAAACTCAAGCGGCTTGGCAT
    CATGCCTTGACCAGTACCACCACTCCAACTGTCATTGTCTTAACCCGTCAAAACTTGGTA
    GTTGAAGAAGGGACAGACTTTGGTAAGGTCGCTAAAGGAGCCTACGTCGTGTATGATACC
    CCGGGATTTGATACTATTATCATTGCTACAGGATCTGAGGTCAATCTAGCTATCAAAGCT
    GCTAAGGAATTGGTTTTACAAGGTGGTAAAGTACGTGTGGTATCTATGCCCTCAACCGAA
    CTATTTGATGCTCAAGATGCTACCTACAAGGAAGACATTTTACCATCTAAGACTCGTCGT
    CGTGTGGCCATTGAAATGGCAGCGACCCAAAGTTGGTACAAGTATGTTGGTTTGGATGGC
    GCGGTCATCGGTATTGACATCTTCGGTGCGTCTGCCCCAGCTCAGACTGTGATTGATAAT
    TATGGATTTACGGTAGAGAATATCGTTGCTCAAGTTAAGTCCCTATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1968

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_1615 [new locus tag: SP_RS07965 ]
  • symbol: RecP-1
  • description: transketolase
  • length: 655
  • theoretical pI: 4.97041
  • theoretical MW: 70828.1
  • GRAVY: -0.105038

⊟Function[edit | edit source]

  • reaction:
    EC 2.2.1.1?  ExPASy
    Transketolase Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate
  • TIGRFAM:
    Metabolism Energy metabolism Pentose phosphate pathway transketolase (TIGR00232; EC 2.2.1.1; HMM-score: 908.2)
    and 5 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other 1-deoxy-D-xylulose-5-phosphate synthase (TIGR00204; EC 2.2.1.7; HMM-score: 63.3)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine 1-deoxy-D-xylulose-5-phosphate synthase (TIGR00204; EC 2.2.1.7; HMM-score: 63.3)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridoxine 1-deoxy-D-xylulose-5-phosphate synthase (TIGR00204; EC 2.2.1.7; HMM-score: 63.3)
    Metabolism Energy metabolism Pyruvate dehydrogenase pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit (TIGR03181; EC 1.2.4.1; HMM-score: 21.4)
    pyruvate dehydrogenase (acetyl-transferring), homodimeric type (TIGR00759; EC 1.2.4.1; HMM-score: 15.7)
  • TheSEED  :
    • Transketolase (EC 2.2.1.1)
    Carbohydrates Central carbohydrate metabolism Pentose phosphate pathway  Transketolase (EC 2.2.1.1)
  • PFAM:
    THDP-binding (CL0254) Transketolase_N; Transketolase, thiamine diphosphate binding domain (PF00456; HMM-score: 500.1)
    and 4 more
    Transket_pyr; Transketolase, pyrimidine binding domain (PF02779; HMM-score: 145)
    TKC_like (CL0591) Transketolase_C; Transketolase, C-terminal domain (PF02780; HMM-score: 58.6)
    THDP-binding (CL0254) TPP_enzyme_C; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain (PF02775; HMM-score: 18.7)
    DXP_synthase_N; 1-deoxy-D-xylulose-5-phosphate synthase (PF13292; HMM-score: 15.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.017388
    • TAT(Tat/SPI): 0.00341
    • LIPO(Sec/SPII): 0.002337
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSLQSVNAIRFLGVDAINKSNSGHPGIVMGAAPMAYSLFTKHLRITPEQPNWINRDRFILSAGHGSMLLYALLHLTGYKDVSMDEIKNFRQWGSKTPGHPEVTHTSGVDATSGPLGQGISTAVGFAQAERFLAAKYNKDGFPIFDHYTYVIAGDGDFMEGVSAEAASYAGHQALDKLIVLYDSNDICLDGETKDTFSENVRVRYDAYGWHTVLVEDGTDLAAISTAIETAKFSGKPSLIEVKTVIGYGSPNKSGTNAVHGAPLGAEETGATRKFLGWDYDPFEVPEEVYSDFKTNVADRGQEAYDAWASLVSDYKVAYPEVASEIDAIVAGKSPVTITEKDFPVYENGFSQATRNSSQDAINTAAVLPTFLGGSADLAHSNMTYIKADGLQDKYNPLNRNIQFGVREFAMGTILNGMALHGGLRVYGGTFFVFSDYVKAAIRLSAIQELPVTYVFTHDSIAVGEDGPTHEPVEHLAGLRSMPNLTVIRPADARETQAAWHHALTSTTTPTVIVLTRQNLVVEEGTDFGKVAKGAYVVYDTPGFDTIIIATGSEVNLAIKAAKELVLQGGKVRVVSMPSTELFDAQDATYKEDILPSKTRRRVAIEMAATQSWYKYVGLDGAVIGIDIFGASAPAQTVIDNYGFTVENIVAQVKSL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CcpA regulon
    CcpA(TF)important in Global catabolite repression; RegPrecise 

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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