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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 14-DEC-2023

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPNA45
  • locus tag: SPNA45_RS03970 [old locus tag: SPNA45_00693 ]
  • pan locus tag?: PNEUPAN002812000
  • symbol: SPNA45_RS03970
  • pan gene symbol?: aliB
  • synonym:
  • product: peptide ABC transporter substrate-binding protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNA45_RS03970 [old locus tag: SPNA45_00693 ]
  • symbol: SPNA45_RS03970
  • product: peptide ABC transporter substrate-binding protein
  • replicon: chromosome
  • strand: +
  • coordinates: 689956..691914
  • length: 1959
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_018594 (689956..691914) NCBI
  • BioCyc: SPNA45_RS03970 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1357 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    ATGAAAAAGTCTAAGAGCAAATATCTAACCTTGGCAGGTCTTGTCCTGGGCACAGGAGTT
    TTATTGAGCGCGTGTGGAAATTCTAGCACGGCGTCAAAAACATACAACTATGTTTATTCA
    AGTGATCCATCTAGCTTGAACTATCTAGCAGAAAACCGCGCAACAACATCCGATATTGTT
    GCAAATTTGGTAGACGGGTTATTAGAAAATGACCAATATGGGAATATTATTCCATCATTA
    GCAGAGGATTGGACTGTTTCTCAGGACGGTTTGACCTATACCTACAAACTTCGTAAGGAT
    GCCAAGTGGTTTACTTCTGAGGGAGAAGAATATGCGCCTGTAACTGCCCAGGATTTTGTG
    ACAGGTTTGCAATATGCAGCTGATAAAAAATCAGAAGCCTTGTATCTAGTGCAGGACTCT
    GTTGCTGGTTTGGATGACTATATCACTGGTAAAACAAGCGACTTTTCAACTGTCGGTGTC
    AAGGCACTTGATGACCAAACGGTTCAATATACTTTGGTTAAACCAGAACTTTACTGGAAT
    TCAAAAACACTTGCAACGATACTTTTTCCTGTTAATGCAGATTTCCTGAAATCAAAAGGG
    GATGATTTTGGGAAGGCGGATCCATCTAGTATTTTGTACAATGGACCTTTCTTGATGAAA
    GCACTTGTCTCAAAATCTGCTATTGAATATAAGAAAAACCCTAATTACTGGGATGCTAAG
    AATGTCTTTGTAGACGATGTGAAATTGACCTACTATGATGGTAGCGACCAAGAATCACTG
    GAACGTAATTTTACAGCTGGTGCTTATACTACGGCTCGTCTTTTTCCTAACAGCTCCAGC
    TATGAAGGGATTAAAGAAAAATACAAAAACAATATCATCTATAGTATGCAAAATTCAACT
    TCATATTTCTTTAATTTTAACCTAGATAGGAAGTCTTACAATTATACTTCTAAAACAAGT
    GACATTGAAAAGAAATCGACTCAGGAAGCAGTTCTCAATAAAAACTTCCGTCAGGCTATC
    AATTTTGCTTTTGACAGAACATCTTATGGGGCTCAGTCTGAAGGGAAAGAAGGTGCAACA
    AAGATTTTGCGTAACCTAGTGGTTCCTCCAAACTTTGTCAGTATCAAGGGAAAAGACTTT
    GGTGAAGTTGTAGCCTCTAAGATGGTCAACTATGGTAAGGAATGGCAAGGTATCAACTTT
    GCGGATGGTCAAGACCCTTACTACAATCCTGAGAAAGCCAAGGCTAAGTTTGCGGAAGCT
    AAGAAAGAACTCGAAGCGAAGGGTGTTCAATTCCCAATCCACTTGGATAAGACTGTGGAA
    GTAACAGATAAAGTAGGCATACAAAGAGTTAATTCTATCAAACAATCAATTGAATCTGTT
    TTAGGTTCTGATAATGTAGTGATTGACATTCAGCAATTAACATCAGATGAGTTTGACAGT
    TCAGGCCACTTTGCTCAAACAGCTGCTCAGAAAGACTATGATTTATATCATGGCGGTTGG
    GGACCTGATTATCAAGACCCGTCAACCTATCTCGATATTTTTAATACTAATAGTGGAGGA
    TTTCTGCAAAATCTTGGACTAGAGCCTGGTGAGGCCAATGACAAGGCTAAGGCAGTTGGA
    CTGGATGTCTATACTCAAATGTTGGAAGAAGCTAATAAAGAACGAGATCCAGCCAAACGT
    TATGAGAAATATGCTGATATTCAAGCTTGGTTGATTGATAGTTCTTTAGTTCTTCCAAGT
    GTTTCGCGTGGGGGAACACCATCATTGAGAAGAACCGTACCATTTGCTGCTGCCTATGGT
    TTAACCGGTACAAAAGGGGTTGAATCATATAAATACCTCAAAGTACAAGATAAGATTGTC
    ACAACAGACGAATATGCAAAAGCTAGAGAAAAATGGTTGAAAGAAAAAGAAGAATCCAAT
    AAAAAAGCCCAAGAAGAATTGGCAAAACATGTCAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1959

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNA45_RS03970 [old locus tag: SPNA45_00693 ]
  • symbol: SPNA45_RS03970
  • description: peptide ABC transporter substrate-binding protein
  • length: 652
  • theoretical pI: 5.20562
  • theoretical MW: 72719.6
  • GRAVY: -0.571626

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Cations and iron carrying compounds nickel ABC transporter, nickel/metallophore periplasmic binding protein (TIGR02294; HMM-score: 47.7)
    and 1 more
    Metabolism Transport and binding proteins Unknown substrate ABC transporter substrate binding protein, KPN_01854 family (TIGR04028; HMM-score: 24.2)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    PBP (CL0177) SBP_bac_5; Bacterial extracellular solute-binding proteins, family 5 Middle (PF00496; HMM-score: 170)
    and 1 more
    no clan defined DUF3991; Protein of unknown function (DUF3991) (PF13154; HMM-score: 18.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0.01
    • Cytoplasmic Membrane Score: 0.53
    • Cellwall Score: 8.75
    • Extracellular Score: 0.7
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0005
    • Cytoplasmic Membrane Score: 0.683
    • Cell wall & surface Score: 0.0902
    • Extracellular Score: 0.2263
  • SignalP: Signal peptide LIPO(Sec/SPII) length 24 aa
    • SP(Sec/SPI): 0.00294
    • TAT(Tat/SPI): 0.00014
    • LIPO(Sec/SPII): 0.996639
    • Cleavage Site: CS pos: 24-25. LSA-CG. Pr: 0.9973
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000748894 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKKSKSKYLTLAGLVLGTGVLLSACGNSSTASKTYNYVYSSDPSSLNYLAENRATTSDIVANLVDGLLENDQYGNIIPSLAEDWTVSQDGLTYTYKLRKDAKWFTSEGEEYAPVTAQDFVTGLQYAADKKSEALYLVQDSVAGLDDYITGKTSDFSTVGVKALDDQTVQYTLVKPELYWNSKTLATILFPVNADFLKSKGDDFGKADPSSILYNGPFLMKALVSKSAIEYKKNPNYWDAKNVFVDDVKLTYYDGSDQESLERNFTAGAYTTARLFPNSSSYEGIKEKYKNNIIYSMQNSTSYFFNFNLDRKSYNYTSKTSDIEKKSTQEAVLNKNFRQAINFAFDRTSYGAQSEGKEGATKILRNLVVPPNFVSIKGKDFGEVVASKMVNYGKEWQGINFADGQDPYYNPEKAKAKFAEAKKELEAKGVQFPIHLDKTVEVTDKVGIQRVNSIKQSIESVLGSDNVVIDIQQLTSDEFDSSGHFAQTAAQKDYDLYHGGWGPDYQDPSTYLDIFNTNSGGFLQNLGLEPGEANDKAKAVGLDVYTQMLEEANKERDPAKRYEKYADIQAWLIDSSLVLPSVSRGGTPSLRRTVPFAAAYGLTGTKGVESYKYLKVQDKIVTTDEYAKAREKWLKEKEESNKKAQEELAKHVK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

J P Claverys, B Grossiord, G Alloing
Is the Ami-AliA/B oligopeptide permease of Streptococcus pneumoniae involved in sensing environmental conditions?
Res Microbiol: 2000, 151(6);457-63
[PubMed:10961459] [WorldCat.org] [DOI] (P p)A R Kerr, P V Adrian, S Estevão, R de Groot, G Alloing, J-P Claverys, T J Mitchell, P W M Hermans
The Ami-AliA/AliB permease of Streptococcus pneumoniae is involved in nasopharyngeal colonization but not in invasive disease.
Infect Immun: 2004, 72(7);3902-6
[PubMed:15213133] [WorldCat.org] [DOI] (P p)Fauzy Nasher, Manfred Heller, Lucy J Hathaway
Streptococcus pneumoniae Proteins AmiA, AliA, and AliB Bind Peptides Found in Ribosomal Proteins of Other Bacterial Species.
Front Microbiol: 2017, 8;2688
[PubMed:29379482] [WorldCat.org] [DOI] (P e)Frank Schmidt, Niamatullah Kakar, Tanja C Meyer, Maren Depke, Ilias Masouris, Gerhard Burchhardt, Alejandro Gómez-Mejia, Vishnu Dhople, Leiv S Håvarstein, Zhi Sun, Robert L Moritz, Uwe Völker, Uwe Koedel, Sven Hammerschmidt
In vivo proteomics identifies the competence regulon and AliB oligopeptide transporter as pathogenic factors in pneumococcal meningitis.
PLoS Pathog: 2019, 15(7);e1007987
[PubMed:31356624] [WorldCat.org] [DOI] (I e)

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