PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 13-DEC-2020

⊟Summary

• organism: Streptococcus pneumoniae SPNA45
• locus tag: SPNA45_RS04625 [old locus tag: SPNA45_00810 ]
• pan locus tag^?: PNEUPAN002720000
• symbol: SPNA45_RS04625
• pan gene symbol^?: glnH_3
• synonym:
• product: ABC transporter substrate-binding protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPNA45_RS04625 [old locus tag: SPNA45_00810 ]
• symbol: SPNA45_RS04625
• product: ABC transporter substrate-binding protein
• replicon: chromosome
• strand: +
• coordinates: 802838..803653
• length: 816
• essential: unknown

⊟Accession numbers

• Location: NC_018594 (802838..803653) NCBI
• BioCyc: SPNA45_RS04625 BioCyc
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1226 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
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  ATGAAATCAAAAAAATGGATATTTGTTTTATGTAATTTTCTTGCAAGTTTCTTCTTAGTA
  GCTTGTCAATCAAGTACGGATAGTTCCCAGTCTGCTGTGGATGCTATCAAACAAAAAGGG
  AAATTAGTTGTGGCAACCAGTCCTGACTATGCACCCTTTGAATTTCAATCATTGGTTGAT
  GGAAAGAACCAGGTAGTCGGTGCAGACATCGACATGGCTCAGTCTATCGCTGATGAACTT
  GGGGTTAAGTTGGAAATCTCAAGCATGAGTTTTGACAATGTTTTGACCAGTCTTCAAACT
  GGTAAGGCTGATCTAGCAGTTGCAGGAATTAGTGCTACTGACGAGAGAAAAGAAGTCTTT
  GATTTTTCAATCCCATACTATGAAAACAAGATTAGTTTCTTGGTTCGTAAGGCTGATGTG
  GAAAAATACAAGGATTTAACTAGCCTAGAAAGTGCTAATATTGCAGCCCAAAAAGGGACT
  GTTCCAGAATCAATGGTCAAGGAACAATTGCCAAAAGCTCAATTAACTTCCCTAACTAAT
  ATGGGTGAAGCAGTCAATGAATTGCAGGCTGGAAAAGTAGATGCTGTTCATATGGATGAG
  CCTGTTGCACTTAGTTATGCTGCTAAAAACGCTGGCTTAGCTGTCGCAACTGTCAGCTTG
  AAGATGAAGGACGGCGACGCCAATGCCGTTGCTCTTAGCAAAAATAGTGATGATTTGAAA
  GAAGTGGTAGACAAGGTTATCCAAAAACTTAAGGATGAAGGAACTTACCAAAGCTATCTT
  GAAAAAGCAGCAAGTCTAACTGAAGTTGAAGAATAA
  60
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  816
  

⊟Protein

⊟General

• locus tag: SPNA45_RS04625 [old locus tag: SPNA45_00810 ]
• symbol: SPNA45_RS04625
• description: ABC transporter substrate-binding protein
• length: 271
• theoretical pI: 4.48402
• theoretical MW: 29273
• GRAVY: -0.12952

⊟Function

• TIGRFAM:
  Metabolism Transport and binding proteins Amino acids, peptides and amines lysine-arginine-ornithine-binding periplasmic protein (TIGR01096; HMM-score: 158.1)
  and 4 more
  Metabolism Transport and binding proteins Amino acids, peptides and amines ectoine/hydroxyectoine ABC transporter solute-binding protein EhuB (TIGR02995; HMM-score: 58.5)
  extracellular substrate-binding orphan protein, GRRM family (TIGR04262; HMM-score: 56.3)
  quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein (TIGR03871; HMM-score: 27.6)
  aromatic cluster surface protein (TIGR04313; HMM-score: 15.6)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  PBP (CL0177) SBP_bac_3; Bacterial extracellular solute-binding proteins, family 3 (PF00497; HMM-score: 189.2)
  and 5 more
  Lig_chan-Glu_bd; Ligated ion channel L-glutamate- and glycine-binding site (PF10613; HMM-score: 39.1)
  Cystatin (CL0121) Cystatin; Cystatin domain (PF00031; HMM-score: 14.8)
  PBP (CL0177) NMT1_2; NMT1-like family (PF13379; HMM-score: 13.9)
  SBP_bac_5; Bacterial extracellular solute-binding proteins, family 5 Middle (PF00496; HMM-score: 13.7)
  H-int (CL0363) Intein_splicing; Intein splicing domain (PF14890; HMM-score: 11.8)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helix: 1
• SignalP: Signal peptide LIPO(Sec/SPII) length 21 aa
  • SP(Sec/SPI): 0.001384
  • TAT(Tat/SPI): 0.000068
  • LIPO(Sec/SPII): 0.998363
  • Cleavage Site: CS pos: 21-22. LVA-CQ. Pr: 0.9987
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000837368 NCBI
• UniProt:

⊟Protein sequence

• MKSKKWIFVLCNFLASFFLVACQSSTDSSQSAVDAIKQKGKLVVATSPDYAPFEFQSLVDGKNQVVGADIDMAQSIADELGVKLEISSMSFDNVLTSLQTGKADLAVAGISATDERKEVFDFSIPYYENKISFLVRKADVEKYKDLTSLESANIAAQKGTVPESMVKEQLPKAQLTSLTNMGEAVNELQAGKVDAVHMDEPVALSYAAKNAGLAVATVSLKMKDGDANAVALSKNSDDLKEVVDKVIQKLKDEGTYQSYLEKAASLTEVEE

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for TIGR4

⊟Expression data

• PneumoExpress for strain D39V: SPV_1226 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications