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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 14-DEC-2023

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPNA45
  • locus tag: SPNA45_RS06315 [old locus tag: SPNA45_01125 ]
  • pan locus tag?: PNEUPAN001753000
  • symbol: SPNA45_RS06315
  • pan gene symbol?: yoaA
  • synonym:
  • product: bifunctional DnaQ family exonuclease/ATP-dependent helicase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNA45_RS06315 [old locus tag: SPNA45_01125 ]
  • symbol: SPNA45_RS06315
  • product: bifunctional DnaQ family exonuclease/ATP-dependent helicase
  • replicon: chromosome
  • strand: +
  • coordinates: 1118886..1121336
  • length: 2451
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_018594 (1118886..1121336) NCBI
  • BioCyc: SPNA45_RS06315 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0705 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    ATGAAAACGATTGGTAATCGCTATGTTGTGGTGGATTTAGAGGCAACTAGCACAGGTAGT
    AAGGCTAAAATTATCCAAGTGGGAATTGTCGTGATTGAGGATGGAGAAATCGTCGATCAC
    TATACGACGGATGTCAATCCACATGAACCCTTGGATGCTCATATCAAAGAACTGACAGGA
    TTGACAGACCAACGTCTGGCGCAAGCACCTGATTTTTCGCAAGTTGCCAAAAAAATCTTT
    GACTTGGTGGAGGATGGGATTTTTGTAGCCCATAATGTTCAGTTTGATGCTAATCTCTTG
    GCGGAAAATTTATTTTTTGAAGGCTATGAGCTAAGAAACCCTCGTGTTGATACGGTCGAA
    TTGGCCCAGGTCTTTTTCCCTGAACTGGAAAAATATAGCTTGCCGATTTTGTGTCGAGAA
    TTAGGAATTCCTCTTAAACACGCACACACAGCCCTTTCAGATGCCCAAGCTACAGCAGAA
    TTACTTCTTTTTTTACGGGAAAAGATGACCCAGCTTCCTAAAGGTCTCTTGGAACGCTTG
    CTGGAAATGGCTGACGCTCTCCTATATGAGTCCTACCTGGTTATTGAGGAAACTTATTGC
    AACCAATCTATCCTGAGTTCTCCAGACTTGGTCCGAGTTCAAGGACTGTATTTTAAGAAA
    ATGGCAGCTTCTCTGGAGCCACGAAAACTATCTCAAGACTTTTCTAAAAATATTTCTCTG
    TTGAACCTTGAAGTGAGGGAGGAACAAGAAAATTTTGCTAAAGAGGTTGGCTTGCTATTG
    AAAGATGAACCTGTCTCTCTGATTCAAGCGCCGACAGGGATTGGGAAAACCTATGGCTAT
    CTCTTACCCGCTTTATCTCAATCCAAAGAGCGACAAATTGTTCTTAGTGTTCCGACAAAG
    ATTCTTCAAAATCAAATTATGGAAGAAGAAGGTAAACGTCTCAAGGAAGTGTTCCATACA
    GATATTCATAGCTTAAAGGGACCACAAAATTATCTGAAGTTGGATGCCTTTTATCATTCC
    TTGCAGGAAAATGATGAAAACCGCTTATTTAGACGCTTTAAAATGCAAGTCTTGGTCTGG
    CTTACTGAGACAGAGACAGGAGATTTGGATGAAATCGGGCAACTCTACCGTTACCAACAT
    TTTCTAGCAGACCTTCGTCATGATGGGAATTTATCATCCCAGAGCTTATTTGTGACGGAA
    GATTTTTGGAAACGTAGTCAAGAAAGGGCAGAGACTTGCAAGCTTTTAGTGACTAATCAT
    GCCTATCTCGTAACCAGACTTGAAGATAATCCTGAATTTGTCAGTGACCGTTTACTGATT
    ATTGATGAAGTCCAAAAGATTTTGTTAGCTCTAGAAAATCTGCTTCAAGAGACCTACGAT
    ATACAATCTATTATCGATTTAATTGATAAGGCTTTAGTAGGAGAAGAAAACAGGGTTCAA
    CAACGGATACTAGAAAGTATTCGCTTTGAGTGTCTCTACTTGATAGAACAATTTCAGTCT
    GGCAAATCTAGGAAAAATATCTTAGATTCTCTGGACAATCTCCATCAGTATTTTTCAGAA
    TTAGAAGTAGAAGGCTTTGATGAGCTGGTTCGCTATTTTACAGCTGAAGGTGATTACTGG
    CTTGAAGTAACTGAAACGAGTCAAAAGAAAATTCAGATTTCTTCTACAAAATCAGGCCGT
    ACTCTTCTGTCCTCTTTACTTCCTGAGAGTTGCCAAGTCTTGGGAGTATCGGCTACTCTT
    GAGATTAGTCAGAGGGTTTCTTTGGCAGACCTTTTAGGCTATCCTGAAGCTAAATTTGTC
    AAGATTGAATCTCGGGGAAAACAGGAACAAGAAGTGGTCATGGTCAAAGATTTCCCTCTG
    GTAACAGAAACCTCCTTAGAAGTCTATGCCAGAGAGGTAGCTGCTTTACTAGTGGAAATT
    CAAGCTTTCCAGCAACCGATTTTGGTTCTCTTTACCGCTAAAGACATGCTTCTAGCAGTA
    TCGGATTTACTTACAGTTAGCCACTTGGCCCAGTATAAAAATGGGGATGTTCATCAGCTA
    AAGAAACGCTTTGAAAAAGGTGAACAACAAATCTTGCTTGGTGCAGCAAGTTTCTGGGAG
    GGAGTTGATTTTTCAAGCCATCCTTTTGTGATTCAAGTTGTACCGAGGCTTCCTTTCCAA
    AATCCTCAAGAACCCTTGACGAAAAAGATTAATCAAGAACTGAATCAAGAAGGGAAAAAT
    GCCTTTTATGATTATCAATTGCCAATGGCCATTATTCGTTTAAAACAGGCTTTGGGAAGA
    AGTATGAGACGTGAATACCAACGTTCCTTAACTCTTATTTTGGATAGGAGAATCGTCGGA
    AAACGATACGGAAAACAAATAGTAGCATCTCTAGCAGAAGAAGCGACTGTTAAAACCATC
    TCTCGATCCGAAGTTGACGAGGCTATTGATAGATTTTTTAATGAACTTTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2451

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNA45_RS06315 [old locus tag: SPNA45_01125 ]
  • symbol: SPNA45_RS06315
  • description: bifunctional DnaQ family exonuclease/ATP-dependent helicase
  • length: 816
  • theoretical pI: 4.85199
  • theoretical MW: 93450.2
  • GRAVY: -0.222672

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair putative DnaQ family exonuclease/DinG family helicase (TIGR01407; HMM-score: 1110.4)
    and 8 more
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, alpha subunit, Gram-positive type (TIGR01405; EC 2.7.7.7; HMM-score: 124.9)
    Genetic information processing DNA metabolism Degradation of DNA exonuclease, DNA polymerase III, epsilon subunit family (TIGR00573; EC 2.7.7.7; HMM-score: 99.1)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, epsilon subunit (TIGR01406; EC 2.7.7.7; HMM-score: 72.8)
    CRISPR type AFERR-associated DEAD/DEAH-box helicase Csf4 (TIGR03117; HMM-score: 47)
    CRISPR-associated helicase Cas3 (TIGR01587; HMM-score: 24.4)
    CRISPR-associated helicase Cas3, subtype CYANO (TIGR03158; HMM-score: 16.5)
    DEXH box helicase, DNA ligase-associated (TIGR04121; EC 3.6.4.-; HMM-score: 16.1)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA repair helicase (rad3) (TIGR00604; EC 3.6.4.-; HMM-score: 15.2)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    RNase_H (CL0219) RNase_T; Exonuclease (PF00929; HMM-score: 100.3)
    P-loop_NTPase (CL0023) Helicase_C_2; Helicase C-terminal domain (PF13307; HMM-score: 86.4)
    and 7 more
    DEAD; DEAD/DEAH box helicase (PF00270; HMM-score: 35.2)
    RNase_H (CL0219) Rv2179c-like; 3'-5' exoribonuclease Rv2179c-like domain (PF16473; HMM-score: 30.1)
    P-loop_NTPase (CL0023) ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 25.7)
    AAA_19; AAA domain (PF13245; HMM-score: 16.1)
    Peptidase_SF (CL0299) Peptidase_S24; Peptidase S24-like (PF00717; HMM-score: 13.8)
    P-loop_NTPase (CL0023) Helicase_C; Helicase conserved C-terminal domain (PF00271; HMM-score: 13.7)
    TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 13)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.95
    • Cytoplasmic Membrane Score: 0.05
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9836
    • Cytoplasmic Membrane Score: 0.0077
    • Cell wall & surface Score: 0.0039
    • Extracellular Score: 0.0048
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.00564
    • TAT(Tat/SPI): 0.000252
    • LIPO(Sec/SPII): 0.000956
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000848687 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKTIGNRYVVVDLEATSTGSKAKIIQVGIVVIEDGEIVDHYTTDVNPHEPLDAHIKELTGLTDQRLAQAPDFSQVAKKIFDLVEDGIFVAHNVQFDANLLAENLFFEGYELRNPRVDTVELAQVFFPELEKYSLPILCRELGIPLKHAHTALSDAQATAELLLFLREKMTQLPKGLLERLLEMADALLYESYLVIEETYCNQSILSSPDLVRVQGLYFKKMAASLEPRKLSQDFSKNISLLNLEVREEQENFAKEVGLLLKDEPVSLIQAPTGIGKTYGYLLPALSQSKERQIVLSVPTKILQNQIMEEEGKRLKEVFHTDIHSLKGPQNYLKLDAFYHSLQENDENRLFRRFKMQVLVWLTETETGDLDEIGQLYRYQHFLADLRHDGNLSSQSLFVTEDFWKRSQERAETCKLLVTNHAYLVTRLEDNPEFVSDRLLIIDEVQKILLALENLLQETYDIQSIIDLIDKALVGEENRVQQRILESIRFECLYLIEQFQSGKSRKNILDSLDNLHQYFSELEVEGFDELVRYFTAEGDYWLEVTETSQKKIQISSTKSGRTLLSSLLPESCQVLGVSATLEISQRVSLADLLGYPEAKFVKIESRGKQEQEVVMVKDFPLVTETSLEVYAREVAALLVEIQAFQQPILVLFTAKDMLLAVSDLLTVSHLAQYKNGDVHQLKKRFEKGEQQILLGAASFWEGVDFSSHPFVIQVVPRLPFQNPQEPLTKKINQELNQEGKNAFYDYQLPMAIIRLKQALGRSMRREYQRSLTLILDRRIVGKRYGKQIVASLAEEATVKTISRSEVDEAIDRFFNEL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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