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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 07-MAR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hu15
  • locus tag: SPNHU15_RS08915 [old locus tag: SPNHU15_01888 ]
  • pan locus tag?: PNEUPAN003389000
  • symbol: SPNHU15_RS08915
  • pan gene symbol?: galE
  • synonym:
  • product: NAD-dependent epimerase/dehydratase family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNHU15_RS08915 [old locus tag: SPNHU15_01888 ]
  • symbol: SPNHU15_RS08915
  • product: NAD-dependent epimerase/dehydratase family protein
  • replicon: chromosome
  • strand: +
  • coordinates: 1769493..1770194
  • length: 702
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP020551 (1769493..1770194) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1648 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    ATGACCAAAACAATTCTTGTTACAGGTGGGACTAGCTACATTGGCTCCCATACCGTTAAA
    GCTCTTTTAAATGCTGGTTATAAGGTGCATGTCCTCGATAATCTCTCCACAGGAAATCGA
    GCGACTGTGGATAATCGTGCTAGCTTTAAAGAACTGGATGTTTATGATGCTAGCGCCTTA
    AAGGCTTACTTAGAAGAAAATCAGATTGATGCTGTCCTCCATTATGCAGGTGAAATTGTT
    GTGAGCGAAAGTATTGAAAATCCAAGTAAATACTTCACTGCCAACGTTGCTGGTAGGAAC
    CAAGTTCTCAAAGTCTTATCTGAAGTTGGCACTCAAAAAATCATGTTCTCTTCGACTGCT
    TCTCTCTATGGAAATAACTGTATTGACAAGCCGGCGACTGAAGATACCCTGATCGACCCT
    GTCAACCCTTATACAGAGACAAAACTGATGGGCGAACGAATGATTTACTGGATGGCCAAT
    CGCTACGACTGGAAATATGTTATTTTCCGTTACTTTAATGTTGCTGGGGCTGAAATGGAT
    GCTTCAAACGGTCTGCGTGTGAAAAATCCAACTCACATCATTCCAAATATCAACAAGACC
    GCATTGGGACAAAATGATAGCTTAAAAATATTTGGAGATGACTACGATACACGTGACGGT
    TCATGTATTCGAGATTACATTTATGTCTTGGACCTTGCATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    702

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNHU15_RS08915 [old locus tag: SPNHU15_01888 ]
  • symbol: SPNHU15_RS08915
  • description: NAD-dependent epimerase/dehydratase family protein
  • length: 233
  • theoretical pI: 5.32494
  • theoretical MW: 25965.2
  • GRAVY: -0.242489

⊟Function[edit | edit source]

  • reaction:
    EC 5.1.3.-?  ExPASy
  • TIGRFAM:
    Metabolism Energy metabolism Sugars UDP-glucose 4-epimerase GalE (TIGR01179; EC 5.1.3.2; HMM-score: 262.3)
    and 19 more
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides dTDP-glucose 4,6-dehydratase (TIGR01181; EC 4.2.1.46; HMM-score: 96.4)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides ADP-glyceromanno-heptose 6-epimerase (TIGR02197; EC 5.1.3.20; HMM-score: 79.1)
    NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family (TIGR04180; HMM-score: 75.3)
    hopanoid-associated sugar epimerase (TIGR03466; HMM-score: 55.7)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides CDP-glucose 4,6-dehydratase (TIGR02622; EC 4.2.1.45; HMM-score: 46.6)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides dTDP-4-dehydrorhamnose reductase (TIGR01214; EC 1.1.1.133; HMM-score: 42.6)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides GDP-mannose 4,6-dehydratase (TIGR01472; EC 4.2.1.47; HMM-score: 36.5)
    UDP-N-acetylglucosamine 4,6-dehydratase (inverting) (TIGR03589; EC 4.2.1.115; HMM-score: 33.9)
    thioester reductase domain (TIGR01746; HMM-score: 32)
    Hypothetical proteins Conserved TIGR01777 family protein (TIGR01777; HMM-score: 26.7)
    2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (TIGR04316; EC 1.3.1.28; HMM-score: 18.1)
    3-hydroxybutyrate dehydrogenase (TIGR01963; HMM-score: 17.4)
    Unknown function Enzymes of unknown specificity SDR family mycofactocin-dependent oxidoreductase (TIGR04504; EC 1.1.99.-; HMM-score: 17.3)
    Metabolism Energy metabolism Fermentation acetoin reductases (TIGR02415; EC 1.1.1.-; HMM-score: 13.6)
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase (TIGR01830; EC 1.1.1.100; HMM-score: 13.1)
    acetoacetyl-CoA reductase (TIGR01829; EC 1.1.1.36; HMM-score: 13)
    Unknown function Enzymes of unknown specificity putative quinone oxidoreductase, YhdH/YhfP family (TIGR02823; HMM-score: 12.7)
    2-hydroxycyclohexanecarboxyl-CoA dehydrogenase (TIGR03206; EC 1.1.1.-; HMM-score: 12.1)
    polyketide-type polyunsaturated fatty acid synthase PfaA (TIGR02813; HMM-score: 8.7)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    NADP_Rossmann (CL0063) Epimerase; NAD dependent epimerase/dehydratase family (PF01370; HMM-score: 174.2)
    GDP_Man_Dehyd; GDP-mannose 4,6 dehydratase (PF16363; HMM-score: 151.8)
    and 9 more
    3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family (PF01073; HMM-score: 55.7)
    RmlD_sub_bind; RmlD substrate binding domain (PF04321; HMM-score: 48.9)
    NAD_binding_4; Male sterility protein (PF07993; HMM-score: 45.1)
    Polysacc_synt_2; Polysaccharide biosynthesis protein (PF02719; HMM-score: 40.7)
    adh_short; short chain dehydrogenase (PF00106; HMM-score: 25.4)
    KR; KR domain (PF08659; HMM-score: 23.6)
    NAD_binding_10; NAD(P)H-binding (PF13460; HMM-score: 22)
    NmrA; NmrA-like family (PF05368; HMM-score: 17)
    CbiJ; Precorrin-6x reductase CbiJ/CobK (PF02571; HMM-score: 12.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.5993
    • Cytoplasmic Membrane Score: 0.0877
    • Cell wall & surface Score: 0.0018
    • Extracellular Score: 0.3113
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.02862
    • TAT(Tat/SPI): 0.001037
    • LIPO(Sec/SPII): 0.004227
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000167845 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MTKTILVTGGTSYIGSHTVKALLNAGYKVHVLDNLSTGNRATVDNRASFKELDVYDASALKAYLEENQIDAVLHYAGEIVVSESIENPSKYFTANVAGRNQVLKVLSEVGTQKIMFSSTASLYGNNCIDKPATEDTLIDPVNPYTETKLMGERMIYWMANRYDWKYVIFRYFNVAGAEMDASNGLRVKNPTHIIPNINKTALGQNDSLKIFGDDYDTRDGSCIRDYIYVLDLA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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