PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 03-APR-2017

⊟Summary

• organism: Streptococcus pneumoniae Hu17
• locus tag: SPNHU17_00588 [new locus tag: SPNHU17_RS02710 ]
• pan locus tag^?: PNEUPAN001397000
• symbol: SPNHU17_00588
• pan gene symbol^?: blpB
• synonym:
• product: Competence-stimulating peptide ABC transporter permease protein ComB

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPNHU17_00588 [new locus tag: SPNHU17_RS02710 ]
• symbol: SPNHU17_00588
• product: Competence-stimulating peptide ABC transporter permease protein ComB
• replicon: chromosome
• strand: -
• coordinates: 538926..539861
• length: 936
• essential: unknown

⊟Accession numbers

• Location: CP020549 (538926..539861) NCBI
• BioCyc: see SPNHU17_RS02710
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0471 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  
  ATGAATTTTACTAAACAATCCCATGATATTGAACTGGGTATCACAAAGACTAACACTGAG
  GTTTCAAATCAAGCTAATCTTGCCAATAGCAGTTCATCAGCTATTGAACAAGAAATTACA
  AAAGTTCAACAACAAATTGGAGAATATCAAGAGCTGAGAGATGCTATCATAAATAACAGA
  GCACGCTTACCAACTAGCAATCCACACCAGTCAATTTTGAATCGTTATCTTGTAGCCTCA
  CAAGGACAAACACAAGGAACGGCAGAGGAGCCATTTTTATCTCAAATTAATCAAAGTATT
  GCAGGTCTTGAATCATCTATCGCAAGCCTCAAAATTCAGCAAGCTGGTATCGGAAGTGTA
  GCAACTTATGATAATAGTTTAGCAACCAAAATTGAAGTACTCCGCACTCAGTTTTTACAA
  ACAGCCTCACAGCAACAACTAACCGTGGAGAACCAATTAACAGAATTAAAAGTACAACTA
  GATCAAGCGACACAGCGCTTAGAAAACAATACCTTAACCGCTCCAAGTAAAGGTATCGTT
  CATCTGAACAGCGAATTTGAAGGTGAAAATAGAATTCCAACTGGTACAGAAATTGCTCAA
  ATATTCCCTATCATCACAGATACAAGAGAAGTACTAATCACTTACTACGTAGCTTCTGAC
  TATCTACCTCTACTAGATAAAGGACAAACTGTAAGATTAAAACTGGAGAAGATTGGAAAT
  CACGGCATTACCATCATCGGCCAACTTCAGACAATTGATCAAACTCCTACCAGAACAGAG
  CAAGGCAATCTCTTTAAATTAACCGCTCTTGCAAAACTATCTAATGAGGATAGTAAACTC
  ATCCAATATGGCTTACAAGGTCGCGTCACTAGTGTAACTGCAAAGAAAACATATTTTGAT
  TATTTCAAAGATAAAATTTTAACCCATTCTGATTAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  936
  

⊟Protein

⊟General

• locus tag: SPNHU17_00588 [new locus tag: SPNHU17_RS02710 ]
• symbol: SPNHU17_00588
• description: Competence-stimulating peptide ABC transporter permease protein ComB
• length: 311
• theoretical pI: 5.70808
• theoretical MW: 34524.5
• GRAVY: -0.427974

⊟Function

• TIGRFAM:
  Metabolism Transport and binding proteins Other bacteriocin secretion accessory protein (TIGR01000; HMM-score: 226)
  and 3 more
  Metabolism Transport and binding proteins Unknown substrate efflux transporter, RND family, MFP subunit (TIGR01730; HMM-score: 35.1)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion membrane fusion protein, HlyD family (TIGR01843; HMM-score: 31.2)
  Metabolism Transport and binding proteins Other efflux pump membrane protein (TIGR00998; HMM-score: 8.4)
• TheSEED: data available for Hungary19A-6, TIGR4
• PFAM:
  Hybrid (CL0105) HlyD_3; HlyD family secretion protein (PF13437; HMM-score: 59.3)
  and 5 more
  HlyD_D23; Barrel-sandwich domain of CusB or HlyD membrane-fusion (PF16576; HMM-score: 19.4)
  no clan defined Filament; Intermediate filament protein (PF00038; HMM-score: 11.6)
  Cnn_1N; Centrosomin N-terminal motif 1 (PF07989; HMM-score: 11.3)
  ABC_tran_CTD; ABC transporter C-terminal domain (PF16326; HMM-score: 10.1)
  TPR_MLP1_2; TPR/MLP1/MLP2-like protein (PF07926; HMM-score: 9.9)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic Membrane
  • Cytoplasmic Score: 1.05
  • Cytoplasmic Membrane Score: 8.78
  • Cellwall Score: 0.08
  • Extracellular Score: 0.09
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.3321
  • Cytoplasmic Membrane Score: 0.3068
  • Cell wall & surface Score: 0.0383
  • Extracellular Score: 0.3228
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.016541
  • TAT(Tat/SPI): 0.003138
  • LIPO(Sec/SPII): 0.003015
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: ARD34196 NCBI
• UniProt:

⊟Protein sequence

• MNFTKQSHDIELGITKTNTEVSNQANLANSSSSAIEQEITKVQQQIGEYQELRDAIINNRARLPTSNPHQSILNRYLVASQGQTQGTAEEPFLSQINQSIAGLESSIASLKIQQAGIGSVATYDNSLATKIEVLRTQFLQTASQQQLTVENQLTELKVQLDQATQRLENNTLTAPSKGIVHLNSEFEGENRIPTGTEIAQIFPIITDTREVLITYYVASDYLPLLDKGQTVRLKLEKIGNHGITIIGQLQTIDQTPTRTEQGNLFKLTALAKLSNEDSKLIQYGLQGRVTSVTAKKTYFDYFKDKILTHSD

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V: SPV_0471 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications