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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 07-MAR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hu17
  • locus tag: SPNHU17_RS03630 [old locus tag: SPNHU17_00791 ]
  • pan locus tag?: PNEUPAN001674000
  • symbol: manA
  • pan gene symbol?: manA
  • synonym:
  • product: mannose-6-phosphate isomerase, class I

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNHU17_RS03630 [old locus tag: SPNHU17_00791 ]
  • symbol: manA
  • product: mannose-6-phosphate isomerase, class I
  • replicon: chromosome
  • strand: +
  • coordinates: 731018..731962
  • length: 945
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP020549 (731018..731962) NCBI
  • BioCyc: SPNHU17_RS03630 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0641 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGTCAGAACCATTATTTTTACAATCAGTTATGCAAGAAAAAATCTGGGGTGGTACCAAG
    CTACGTGATGAGTTTGGCTACGACATCCCAAGTGAAAAAGTCGGAGAGTACTGGGCTATC
    TCAGCTCATCTAAATGGTGTTTCTAAAGTTGCCAATGGTCGTTACGAGGGAACAGATCTT
    GCTACTTTGTATGCGGAACACCGTGAATTATTTGGCAATCGTCCAGAACCTGTATTTCCA
    CTTTTGACCAAGATCCTCGATGCCAACGACTGGCTCAGTGTCCAAGTTCACCCAGACGAT
    GCTTATGGACTCGAGCATGAAGACGAACTTGGAAAAACAGAATGTTGGTACATCATTGCA
    GCAGATGAAGGTTCAGAGATTATCTACGGTCACAATGCCAAGTCAAAAGAAGAACTCCGC
    CAGCAAATCGAGGACAAGAACTGGGATGACTTGTTGACCAAAGTCCCTGTTAAGGCTGGA
    GATTTCTTCTATGTACCAAGTGGCACCATGCATGCTATCGGTACTGGCATCTTGATTCTT
    GAAACCCAACAGTCTAGTGATACAACTTACCGCGTCTATGACTTTGACCGAAAGGACGAT
    AAGGGCAACTTGCGTGAACTTCACCTTGAAAAATCCATCGATGTTTTGAACATTGGCGAG
    CCAGCAAATAGCCGTCCTGTAACTGTTAAAGCAGATAATTTGCGTTCCACTTTACTTGTT
    TCTAATGATTTCTTCGCAGTTTACAAGTGGGAAATCACTGGAAAAGTTGATTTTGAGAAG
    ACAGCTGACTACAGCTTGTTGAGTGTCTTGGCTGGTCAAGGTCAACTAACTGTTGACGGG
    AAAAACTATCCAATCCAAAAAGGGAGACACTTTATCCTACCAAGTGATGTTGAATCTTGG
    ACTCTAGAAGGGCAAGATTTAGAATTAATTGTTAGTCATCCATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    945

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNHU17_RS03630 [old locus tag: SPNHU17_00791 ]
  • symbol: ManA
  • description: mannose-6-phosphate isomerase, class I
  • length: 314
  • theoretical pI: 4.49691
  • theoretical MW: 35484.5
  • GRAVY: -0.444586

⊟Function[edit | edit source]

  • reaction:
    EC 5.3.1.8?  ExPASy
    Mannose-6-phosphate isomerase D-mannose 6-phosphate = D-fructose 6-phosphate
  • TIGRFAM:
    Metabolism Energy metabolism Sugars mannose-6-phosphate isomerase, class I (TIGR00218; EC 5.3.1.8; HMM-score: 246.8)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    Cupin (CL0029) PMI_typeI_cat; Phosphomannose isomerase type I, catalytic domain (PF20511; HMM-score: 86)
    and 6 more
    Cupin_2; Cupin domain (PF07883; HMM-score: 32.8)
    AraC_binding; AraC-like ligand binding domain (PF02311; HMM-score: 23.7)
    PMI_typeI_C; Phosphomannose isomerase type I C-terminal (PF01238; HMM-score: 19.5)
    Cupin_3; EutQ-like cupin domain (PF05899; HMM-score: 15)
    JmjC; JmjC domain, hydroxylase (PF02373; HMM-score: 14)
    CENP-C_C; Mif2/CENP-C like (PF11699; HMM-score: 13.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9989
    • Cytoplasmic Membrane Score: 0.0004
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0006
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007233
    • TAT(Tat/SPI): 0.000392
    • LIPO(Sec/SPII): 0.000881
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001294315 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSEPLFLQSVMQEKIWGGTKLRDEFGYDIPSEKVGEYWAISAHLNGVSKVANGRYEGTDLATLYAEHRELFGNRPEPVFPLLTKILDANDWLSVQVHPDDAYGLEHEDELGKTECWYIIAADEGSEIIYGHNAKSKEELRQQIEDKNWDDLLTKVPVKAGDFFYVPSGTMHAIGTGILILETQQSSDTTYRVYDFDRKDDKGNLRELHLEKSIDVLNIGEPANSRPVTVKADNLRSTLLVSNDFFAVYKWEITGKVDFEKTADYSLLSVLAGQGQLTVDGKNYPIQKGRHFILPSDVESWTLEGQDLELIVSHP

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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