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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 07-MAR-2025
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae Hu17
- locus tag: SPNHU17_RS04535 [old locus tag: SPNHU17_00987 ]
- pan locus tag?: PNEUPAN001916000
- symbol: SPNHU17_RS04535
- pan gene symbol?: holB
- synonym:
- product: DNA polymerase III subunit delta'
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SPNHU17_RS04535 [old locus tag: SPNHU17_00987 ]
- symbol: SPNHU17_RS04535
- product: DNA polymerase III subunit delta'
- replicon: chromosome
- strand: +
- coordinates: 911989..912879
- length: 891
- essential: unknown other strains
⊟Accession numbers[edit | edit source]
- Location: NZ_CP020549 (911989..912879) NCBI
- BioCyc: SPNHU17_RS04535 BioCyc
- MicrobesOnline:
- PneumoBrowse for strain D39V: SPV_0826 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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841ATGAAACAAGATCAACTAAAGGCTTGGCAACCAGCTCAGTTTGACCGTTTTGTCCGTATC
TTAGAACAAGACCAGCTCAATCACGCCTATCTCTTTTCAGGTTTCTTTGGAAGCTTGGAA
ATGGCGCAATTTTTAGCTAAGAGCCTCTTTTGTACGGATAAAGTTGGCGTCTTACCATGT
GAGAAATGCCGAAGTTGCAAGCTGATTGAACAGGAAGAGTTTCCAGATGTCACCTTGATT
AAGCCAGTCAATCAGGTCATCAAGACAGAACGCATTCGGGAATTGGTGGGACAGTTTTCT
CAAGCAGGGATTGAAAGCCAGCAACAGGTCTTTATCATCGAGCAAGCGGATAAAATGCAT
CCCAACGCAGCCAATTCTCTGCTCAAGGTCATCGAAGAACCCCAGAGTGAAGTTTATATT
TTCTTCTTGACTAGCGATGAGGAAAAGATGTTACCGACAATCCGAAGTCGGACTCAGATC
TTCCACTTTAAAAAGCAAGAAGAAAAACTTATCTTACTCTTAGAACAAATGGGACTTGTT
AAGAAAAAAGCGACTCTTTTAGCTAAGTTTAGTCAATCGCGAGCTGAAGCAGAAAAGTTG
GCTAATCAGGCAAGTTTTTGGACCTTGGTCGATGAAAGTGAACGCCTGCTGACTTGGTTA
GTAGCTAAGAAAAAAGAAAGTTATCTACAGGTTGCCAAATTAGCCAACTTGGCAGATGAT
AAGGAAAAACAGGATCAGGTTTTACGGATTCTTGAAGTTCTCTGTGGGCAGGACCTCTTG
CAGGTAAGAGTAAGAGTGATTCTACAAGATTTACTAGAAGCTAGAAAAATGTGGCAAGCT
AATGTCAGCTTTCAAAATGCCATGGAATATCTGGTCTTGAAAGAAATATAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SPNHU17_RS04535 [old locus tag: SPNHU17_00987 ]
- symbol: SPNHU17_RS04535
- description: DNA polymerase III subunit delta'
- length: 296
- theoretical pI: 6.77785
- theoretical MW: 34358.8
- GRAVY: -0.213176
⊟Function[edit | edit source]
- reaction: EC 2.7.7.7? ExPASyDNA-directed DNA polymerase Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
- TIGRFAM: DNA metabolism DNA replication, recombination, and repair DNA polymerase III, delta' subunit (TIGR00678; EC 2.7.7.7; HMM-score: 191.9)and 2 moreDNA metabolism DNA replication, recombination, and repair DNA polymerase III, subunit gamma and tau (TIGR02397; EC 2.7.7.7; HMM-score: 112.9)hopanoid biosynthesis associated protein HpnK (TIGR03473; HMM-score: 20.1)
- TheSEED: data available for D39, Hungary19A-6, TIGR4
- PFAM: P-loop_NTPase (CL0023) DNA_pol3_delta2; DNA polymerase III, delta subunit (PF13177; HMM-score: 189.9)and 1 moreAAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 18.2)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9384
- Cytoplasmic Membrane Score: 0.0409
- Cell wall & surface Score: 0.0107
- Extracellular Score: 0.01
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.00908
- TAT(Tat/SPI): 0.00434
- LIPO(Sec/SPII): 0.000586
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq: WP_000806714 NCBI
- UniProt:
⊟Protein sequence[edit | edit source]
- MKQDQLKAWQPAQFDRFVRILEQDQLNHAYLFSGFFGSLEMAQFLAKSLFCTDKVGVLPCEKCRSCKLIEQEEFPDVTLIKPVNQVIKTERIRELVGQFSQAGIESQQQVFIIEQADKMHPNAANSLLKVIEEPQSEVYIFFLTSDEEKMLPTIRSRTQIFHFKKQEEKLILLLEQMGLVKKKATLLAKFSQSRAEAEKLANQASFWTLVDESERLLTWLVAKKKESYLQVAKLANLADDKEKQDQVLRILEVLCGQDLLQVRVRVILQDLLEARKMWQANVSFQNAMEYLVLKEI
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_0826 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]