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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 25-AUG-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hu17
  • locus tag: SPNHU17_RS04715 [old locus tag: SPNHU17_01024 ]
  • pan locus tag?: PNEUPAN002008000
  • symbol: SPNHU17_RS04715
  • pan gene symbol?: trmR
  • synonym:
  • product: O-methyltransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNHU17_RS04715 [old locus tag: SPNHU17_01024 ]
  • symbol: SPNHU17_RS04715
  • product: O-methyltransferase
  • replicon: chromosome
  • strand: +
  • coordinates: 944422..945135
  • length: 714
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP020549 (944422..945135) NCBI
  • BioCyc: SPNHU17_RS04715 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0867 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    ATGGTTGAATCGTATAGTAAGAATGCTAACCATAACATGCGTCGTCCTGTCGTCAAAGAA
    GAAATTGTAGACTTGATGCGTCAGCGTCAAAAGCAGGTCACAGGTTTCTTGAAAGAATTG
    GAAGACTTTGCCCGCAAGGAAAATATTCCTATTATTCCCCATGAAACGGTTGCTTATTTC
    CGTTTTCTTATGGAAACCATGCAGCCTAAAAATATTCTGGAAATTGGGACGGCTATCGGT
    TTTTCAGCTCTCTTGATGGCTGAACATGCGCCAAATGCTAAGATTACAACTATTGATCGT
    AATCCAGAAATGATTGGTTTTGCCAAGGAAAATTTTGCCCAGTTTGACAGTCGCAAGCAA
    ATCACTCTCCTAGAGGGAGATGCGGTGGATGTCTTATCTACACTGACAGAGTCTTATGAT
    TTCGTATTTATGGATTCTGCCAAGTCTAAATACATCGTCTTTCTGCCAGAAATCCTCAAA
    CATTTGGAAGTTGGTGGTGTGGTTGTCTTGGATGATATTTTTCAAGGTGGTGATGTTGCC
    AAGGATATTATGGAAGTCCGTCGTGGTCAGCGAACCATTTATCGAGGCCTTCAAAAATTA
    TTTGATGCAACCTTAGACAATCCAGAACTCACCGCAACATTAGTGCCTTTAGGAGATGGT
    ATTCTCATGCTTCGTAAAAATGTAGCAGATGTTCAACTGTCTGAAAGCGAATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    714

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNHU17_RS04715 [old locus tag: SPNHU17_01024 ]
  • symbol: SPNHU17_RS04715
  • description: O-methyltransferase
  • length: 237
  • theoretical pI: 4.91611
  • theoretical MW: 26867.8
  • GRAVY: -0.157384

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit (TIGR02469; EC 2.1.1.132; HMM-score: 46.8)
    and 16 more
    Genetic information processing Protein synthesis Ribosomal proteins: synthesis and modification protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific (TIGR03533; EC 2.1.1.-; HMM-score: 31.7)
    Genetic information processing Protein fate Protein modification and repair protein-(glutamine-N5) methyltransferase, release factor-specific (TIGR03534; EC 2.1.1.-; HMM-score: 29.5)
    Genetic information processing Protein fate Protein modification and repair methyltransferase, HemK family (TIGR00536; HMM-score: 23.8)
    Unknown function Enzymes of unknown specificity tRNA (cmo5U34)-methyltransferase (TIGR00740; EC 2.1.1.-; HMM-score: 23.2)
    Unknown function Enzymes of unknown specificity putative methylase (TIGR00537; HMM-score: 22.7)
    methyltransferase, ATP-grasp peptide maturase system (TIGR04188; HMM-score: 21.7)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA (guanine-N(7)-)-methyltransferase (TIGR00091; EC 2.1.1.33; HMM-score: 20.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Biotin malonyl-acyl carrier protein O-methyltransferase BioC (TIGR02072; EC 2.1.1.-; HMM-score: 20.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone ubiquinone/menaquinone biosynthesis methyltransferase (TIGR01934; EC 2.1.1.-; HMM-score: 19.9)
    methyltransferase, FxLD system (TIGR04364; HMM-score: 18.5)
    Genetic information processing Protein synthesis tRNA and rRNA base modification 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG (TIGR00138; EC 2.1.1.170; HMM-score: 18.4)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides putative sugar O-methyltransferase (TIGR04371; EC 2.1.1.-; HMM-score: 17.8)
    methyltransferase, Rta_06860 family (TIGR04290; EC 2.1.1.-; HMM-score: 17.4)
    Genetic information processing Protein synthesis tRNA and rRNA base modification ribosomal RNA small subunit methyltransferase A (TIGR00755; EC 2.1.1.182; HMM-score: 16.6)
    Genetic information processing Protein fate Protein modification and repair protein-L-isoaspartate O-methyltransferase (TIGR00080; EC 2.1.1.77; HMM-score: 15.8)
    methyltransferase, FkbM family (TIGR01444; HMM-score: 15.8)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    NADP_Rossmann (CL0063) Methyltransf_3; O-methyltransferase (PF01596; HMM-score: 102.6)
    and 19 more
    Methyltransf_24; Methyltransferase domain (PF13578; HMM-score: 49)
    Methyltransf_31; Methyltransferase domain (PF13847; HMM-score: 45.8)
    Methyltransf_25; Methyltransferase domain (PF13649; HMM-score: 37.7)
    Methyltransf_11; Methyltransferase domain (PF08241; HMM-score: 30.5)
    MTS; Methyltransferase small domain (PF05175; HMM-score: 27.5)
    Met_10; Met-10+ like-protein (PF02475; HMM-score: 24.5)
    Methyltransf_23; Methyltransferase domain (PF13489; HMM-score: 24)
    Methyltransf_12; Methyltransferase domain (PF08242; HMM-score: 23.9)
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) (PF01135; HMM-score: 22.8)
    Spermine_synth; Spermine/spermidine synthase domain (PF01564; HMM-score: 21.3)
    Methyltransf_4; Putative methyltransferase (PF02390; HMM-score: 19.1)
    Methyltransf_16; Lysine methyltransferase (PF10294; HMM-score: 17.3)
    CmcI; Cephalosporin hydroxylase (PF04989; HMM-score: 16.8)
    Methyltransf_15; RNA cap guanine-N2 methyltransferase (PF09445; HMM-score: 15.7)
    Cons_hypoth95; Conserved hypothetical protein 95 (PF03602; HMM-score: 15.3)
    GidB; rRNA small subunit methyltransferase G (PF02527; HMM-score: 13.9)
    Methyltransf_5; MraW methylase family (PF01795; HMM-score: 13.4)
    Rsm22; Mitochondrial small ribosomal subunit Rsm22 (PF09243; HMM-score: 13.4)
    ADH_zinc_N; Zinc-binding dehydrogenase (PF00107; HMM-score: 11.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002076
    • TAT(Tat/SPI): 0.000283
    • LIPO(Sec/SPII): 0.000321
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000230399 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MVESYSKNANHNMRRPVVKEEIVDLMRQRQKQVTGFLKELEDFARKENIPIIPHETVAYFRFLMETMQPKNILEIGTAIGFSALLMAEHAPNAKITTIDRNPEMIGFAKENFAQFDSRKQITLLEGDAVDVLSTLTESYDFVFMDSAKSKYIVFLPEILKHLEVGGVVVLDDIFQGGDVAKDIMEVRRGQRTIYRGLQKLFDATLDNPELTATLVPLGDGILMLRKNVADVQLSESE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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