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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 11-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae INV200
  • locus tag: SPNINV200_RS03955 [old locus tag: SPNINV200_07390 ]
  • pan locus tag?: PNEUPAN001791000
  • symbol: SPNINV200_RS03955
  • pan gene symbol?: pdp
  • synonym:
  • product: pyrimidine-nucleoside phosphorylase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNINV200_RS03955 [old locus tag: SPNINV200_07390 ]
  • symbol: SPNINV200_RS03955
  • product: pyrimidine-nucleoside phosphorylase
  • replicon: chromosome
  • strand: +
  • coordinates: 747333..748610
  • length: 1278
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_017593 (747333..748610) NCBI
  • BioCyc: SPNINV200_RS03955 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0736 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGAGAGCAGTTGATTTAATCCAAAAAAAACGAGACGGTCAAGAACTGACTTCAAGTGAA
    ATTGAATGGCTGATAGAAGGCTATGTATCAGGAACTGTTCCTGATTATCAGATGTCTGCC
    TTTGCTATGGCTGTTTATTTTAAAGGAATGACGACTCGAGAAATCTCTGATTTAACGATG
    AATATGGTTAAGACTGGGCAAGAGTTTGACCTGTCAGCCATTGATGGTGTGAAAGTTGAC
    AAGCATTCTACTGGTGGTGTCGGCGATAAGGTAACCTTGATTTTAGCTCCTCTTGTTGCT
    AGCTTCGGTGTGCCTGTAGCAAAAATGAGTGGTCGTGGTCTTGGCCATACAGGCGGAACA
    ATTGATAAATTGGAGTCCATTAAGGGCTATCAAGTAGAACGTAGTCAAGAGGATTTTATT
    CGTCAGGTTCAGGATATTGGAGTATCTGTCATTGGGCAATCAGACCAGCTGGTCAAAGCA
    GATAAGCTTCTCTATGCCCTTCGTGATGTGACCGCAACTGTCGACACGATTCCTTTGATT
    GCGAGTTCGGTGATGAGCAAGAAAATTGCGGCAGGGGCGGATGCTATTTTGCTAGACGTG
    ACTGTCGGTGAGGGTGCCTTCATGAAGACGGTTGATGAGGCGCGTGAGTTGGCTCAAACT
    ATGGTAGATCTTGGTAAGGTTGTTGGACGGAAGACAGTAGCAGTGATTACGGATATGAGC
    CAGCCTTTGGGACGAGCGATTGGAAATCGTCTGGAAATCCTTGAAGCATTGGAGATTTTG
    CAAGGTCAAGGACGTCAGGATATTACCCACTTTATTTGTGAATTGGCTCAAATTATGCTT
    GGTTTGGCAAATGTTAACAAAACTGTTGAAGAAGTTCGCCAACATCTTGAGAATGGTCAA
    GCACTGGCTAAGTTTGAGGAAATGGTGCAAGCCCAAGGTGGAGACTTGGAAGACCTCTAT
    CGTCCTGTAAATGTAGCTCATGTGGTGGAAATCCCTGCTCAGGAAACGGGTGTCATTTCA
    GCTCTTCCAGCTATGGACTTTGGTCTTTATGCCATGAGGCTGGGTGCTGGTCGTGCAGTT
    AAGTCTGATGCCTTGGACTATGAAACAGGAATTGTTTTTGAAAAGAAGATTGGAGACTCC
    GTTCAAAAGGGTGAAATTGTTGCAAAAGTATACACAAATGAAAAAATTCCACCTCAACTA
    GTTACAGATTTCCAAAAATGTGTTAAAATAAGTGATGAAGTGAAAAAAATCCGTGAAATT
    GTAGAAATCATCTCCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1278

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNINV200_RS03955 [old locus tag: SPNINV200_07390 ]
  • symbol: SPNINV200_RS03955
  • description: pyrimidine-nucleoside phosphorylase
  • length: 425
  • theoretical pI: 4.76317
  • theoretical MW: 46145.9
  • GRAVY: 0.0124706

⊟Function[edit | edit source]

  • reaction:
    EC 2.4.2.2?  ExPASy
    Pyrimidine-nucleoside phosphorylase Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate 2'-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Other pyrimidine-nucleoside phosphorylase (TIGR02644; EC 2.4.2.2; HMM-score: 566.6)
    and 5 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Other thymidine phosphorylase (TIGR02643; EC 2.4.2.4; HMM-score: 377.2)
    AMP phosphorylase (TIGR03327; EC 2.4.-.-; HMM-score: 228.6)
    putative thymidine phosphorylase (TIGR02645; EC 2.4.2.4; HMM-score: 221.6)
    Metabolism Amino acid biosynthesis Aromatic amino acid family anthranilate phosphoribosyltransferase (TIGR01245; EC 2.4.2.18; HMM-score: 51.9)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair nucleoside triphosphatase YtkD (TIGR02705; EC 3.6.1.-; HMM-score: 12.1)
  • TheSEED: see SPNINV200_07390
  • PFAM:
    no clan defined Glycos_transf_3; Glycosyl transferase family, a/b domain (PF00591; HMM-score: 142.3)
    and 5 more
    Glycos_trans_3N; Glycosyl transferase family, helical bundle domain (PF02885; HMM-score: 84.9)
    Hybrid (CL0105) PYNP_C; Pyrimidine nucleoside phosphorylase C-terminal domain (PF07831; HMM-score: 82)
    DUF2254; Predicted membrane protein (DUF2254) (PF10011; HMM-score: 13.2)
    no clan defined DUF2959; Protein of unknown function (DUF2959) (PF11172; HMM-score: 12.6)
    CmlA_N; Diiron non-heme beta-hydroxylase N-terminal domain (PF18456; HMM-score: 11.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9986
    • Cytoplasmic Membrane Score: 0.0006
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0007
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004243
    • TAT(Tat/SPI): 0.000506
    • LIPO(Sec/SPII): 0.000481
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001202947 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MRAVDLIQKKRDGQELTSSEIEWLIEGYVSGTVPDYQMSAFAMAVYFKGMTTREISDLTMNMVKTGQEFDLSAIDGVKVDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTIDKLESIKGYQVERSQEDFIRQVQDIGVSVIGQSDQLVKADKLLYALRDVTATVDTIPLIASSVMSKKIAAGADAILLDVTVGEGAFMKTVDEARELAQTMVDLGKVVGRKTVAVITDMSQPLGRAIGNRLEILEALEILQGQGRQDITHFICELAQIMLGLANVNKTVEEVRQHLENGQALAKFEEMVQAQGGDLEDLYRPVNVAHVVEIPAQETGVISALPAMDFGLYAMRLGAGRAVKSDALDYETGIVFEKKIGDSVQKGEIVAKVYTNEKIPPQLVTDFQKCVKISDEVKKIREIVEIIS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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