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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 11-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae INV200
  • locus tag: SPNINV200_RS05735 [old locus tag: SPNINV200_10710 ]
  • pan locus tag?: PNEUPAN002299000
  • symbol: zmpD
  • pan gene symbol?: zmpD
  • synonym:
  • product: zinc metalloprotease D

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNINV200_RS05735 [old locus tag: SPNINV200_10710 ]
  • symbol: zmpD
  • product: zinc metalloprotease D
  • replicon: chromosome
  • strand: -
  • coordinates: 1086907..1092312
  • length: 5406
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_017593 (1086907..1092312) NCBI
  • BioCyc: SPNINV200_RS05735 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    3061
    3121
    3181
    3241
    3301
    3361
    3421
    3481
    3541
    3601
    3661
    3721
    3781
    3841
    3901
    3961
    4021
    4081
    4141
    4201
    4261
    4321
    4381
    4441
    4501
    4561
    4621
    4681
    4741
    4801
    4861
    4921
    4981
    5041
    5101
    5161
    5221
    5281
    5341
    5401
    TTGTCATTATTAAAAAAAGATAAATTTTCCATTCGGAAAATAAAGGGTATTGTTGGTTCG
    GTATTCTTGGGGAGTCTTTTATTTGCACCGTCAGTTGTTGGTGCATCGACTTATCATTAC
    TTAGATTATAGTAGTTTGACACAAACTGAACGTGATCAACTCAAACAAGGTAGACCTGAT
    GAATCCAAAGAGTCATATGCTTTGGATTATGAAAAAGACGCACTACCAAACACAGGAAGT
    TCTCAATCTATTATGACTGCATTGGGTTTGTTAGCTATCGGGAGTCTTATTGTGATTATC
    ACAAAAGATAATAGAAATAAAAAAATAGCTACATTTTTGATTGTAGGGGCGACAGGTTTA
    GTTACACTATCAACTGCTTCAGCACTTAATTTGAATGCTAACATCCATGAGTCTGGACGT
    GATGGTGTGTTGCAAATTTCTGGTTACAGATATGTTGGTTACTTGGAGCTTGATGATAAA
    ACTGTTTCGTCGGTTTCTCCAGCATCAACTGTTTCGCCAGTTGAGCAACCCAAAGTTGTA
    ACAGAGAAAGGGGAACCGGAGGTTCAACCAGCCTTACCCGAAGCTGTTGTGACTGACAAA
    GGCGAACCGGAAGTACAACCGACATTACCAGAAGCTGTTGTGACTGACAAAGGCGAACCA
    GAAGTTCATGAGAAGCCTGACTATACGCAACCAATAGGTGCAAACCTTGTTGAGCCTGAA
    GTTCATGAGAAACTAGCATACACTGAATCAGTAGGTACAACAGGAATGGATGAAAACGGA
    AACTTGATTGAACCACCTGTTAGCGATATTCCAGAATACACTGAATCAGTAGGTACAACA
    GGAGTGGACGAAAATGGAAACTTGATTGAACCACCTGTTAGCGATATTCCAGAATACACT
    GAATCAGTAGGTACAACAGGAGTGGACGAAAACGGAAACTTGATTGAACCACCTGTTAAC
    GACATTCCAGAGTATACTGAACCAATATCTACAGTTTCAGAAGTTGCATCAGAAAGAGAA
    GAGTTGCCTTCTTTACATACCGATATTCGTACAGAGACTATTCCTAAAACCACTATAGAA
    GAATCTGATCCTAGCAAATTTATAGGCGATGATTCTGTTAAAGAAGTTGGTGAGGATGGC
    GAACGTCAAATTGTTACTAGCTATGAAGAGTTACATGGCAAAAAAATTAGTGAACCAGTT
    GAAACGGTAACAATTTTGAAAGAAATGAAACCTAAAATTCTTGTAAAAGGTACAAAAGAA
    AATCCAAAAGAAAAAACAGTTCCCGTTTTGACCTTGACCAAAGTAACAGAAGATGCTATG
    AATCGTTCTGCCAACTTAAATTATGAGCTTGATAATAAAGATAATGCTGAAATATCAAGT
    ATTATAGCTGAAATTAAAGATGGTGATACAGTAGTTAAAAAGGTTGATTTATCTAAAGAA
    AAATTAACTGACGCTGTACAAAATTTGGATTTGTTTAAAGATTATAAGATTGCAACAACA
    ATGATTTATGATCGTGGTCAAGGTTCTGAAACGTCTAAACTGGATGAAAAAACTTTGCGT
    TTGGAGTTGAAAAAGGTCGAAATTAAAAATATTTCATCTACTAATTTAGTGAAGGTAAAT
    GATGATGGTACTGAAATACCTAGTGATTTCATGAGCGAAAAACCTTCTGATGAAGATGTG
    AAGAAAATGTACTTAAAAATCACTAGTCGTGATAATAAAGTAACTCGTTTAGCAGTTGAT
    AAGATTGAGTTAGTAACTGAAAAAGAAAAAGAACTTTATAAAATTACAGCAAGCGCTCAA
    GATTTAATTCAACATGTCGATCCATCTAAGACTAGAAATGAATACATTCATTACATTGAA
    AAACCAGTTCCAAAAGTCAATAATGTATATTACAATTTCAATGAACTTGTGAGAGATATG
    CAAGAACATCCAAATGACGAGTTTAAATTGGGTGCTGACCTTAATGCCACAAATGTATCA
    GCATTTGGTAAATCATATGTTACGAAAGATTTCAAAGGTAAGCTCTTGAGTGATGGTGAT
    AATCACTATACCATTCATAACTTGTCACGTCCGTTATTTGGCAATGTTATTGGTGGAACG
    ATTAAGAATATTAATCTTGGTAATGTTGACATAAATATGCCATGGGCGAACCAAGTTGCA
    GCTGTAGCGAATATTATTAAAGGTGGAACTACCATTGAAAATGTTAAGGTTAAAGGTAAT
    ATAGTAGGTAAAGATTGGGTATCTGGATTTATTGATAAGATTGATAACCAAGGTACACTC
    AGAAATGTGGCCTTTATCGGTAACGTAACTTCTGTCGGCGATGGTGGACAATTCTTGACT
    GGTATCGTTGGTGAGAACTGGAAAGGACTCGTCGAACGCGCGTATGTTAACGCAAATCTT
    ATTGGCAAGAAAGCCAAGGCTGCGGGCATTGCTTATTGGACACAAAATGAAGGAAATAAC
    AATACTGTTCGTCAGGAAGGAGCAATCAAAAAATCTATTGCTAAGGGAACAATTCAAGTA
    ACTGAGGCGATTGAAAGTGGTGGTGTTGTAGGAAGCATGAAGCACCACGGTTCTGTCGAA
    GATTCAGTTTCCATGATGAAGGTACCTAATGGTGAAATTTTCTATGGTTCTAGTGATATT
    GATTATGATGATGGCTACTGGACAGGAGATAATGTAAGACGAAATTATGTTGTAATAGGT
    GTTAGTGATGGGCATTCTAGCTACCAGCGTTCAAAAGATAAAAATCGTATCAGACCTATT
    TCTGAGGAAGAGGCAAAATCTAAAATTGAAGCTACAGGAATTACCGCAGATAAATACGAA
    ATCAATGAACCTGTGGTCAATCGCTTAAATCGTTTAACCAGAAGAGAAGATGAATATAAG
    TCAACCCAAGACTATAAAGTAGATCGAGATCTGGCTTATCGTAATATTGAGAAACTGCAA
    CCATTTTATAACAAAGAATGGATTGTCAATCAAGGTAACAAACTTGCAGAAGATTCAAAC
    TTAGCTAAGAAAGAAGTCCTTTCTGTTACGGGTATGAAGGATGGTCAATTCGTGACCGAT
    TTATCAGATATTGATCATGTGATGATTCACTATGCAGATAAGACTAAAGAAATCAAAGCT
    GTTCATCAAAAAGAGTCTAAAGTAGCGCAAGTTCGTGAGTATAGTATCGATGGATTAGAT
    GACATTGTTTATACACCAAACATGGTTGATAAAAATCGTGATCAATTGATTAAAGACATT
    AAAGATAGGTTAGCAACTGTTGAATTAATTTCTCCCGAAGTCCGTGCTTTGATGGATAAA
    CGAGATACATCTAGAGATCCTAATGCTAATTCGGATGAGCGTAAGAATGGTTATATCCGA
    GACCTTTATTTCGAAGAAAGTTTTTCTGAAACGAAAGCTAATCTTGATAAATTGGTCAAA
    TCTTTGATTGAAAATGCTGACCATCAATTAAATAGTGACGAAGCAGCTATGAAAGCACTT
    GTTAAGAAGGTGGATGAAAATAAAGCTAAAATCGTGATGGCTCTTACTTACCTTAATCGT
    TACTATGATATCAAGTATGGGGATATGACTATCAAAAACTTGATGATGTTTAAACCTGAT
    TTCTATGGTAAGTCAGTTGACCTTCTTGACTTCTTGATTCGAATTGGATCAAGTGAGCGA
    AATATCAAGGGTGACAGAACTTTGGATGCTTATCGTGATATGATTGGTGGAACTATTGGT
    AAGTCTGAATTACATGGCTTCTTAGATTACAACATGCGTCTCTTCACTAACGATACTGAT
    TTAAATGATTGGTTTATCCATGCGGCTAAGAACGTATACATTGTGGAGCCTAAAACAACG
    AACCCAGATTTTGTTAATAAACGACATCGTGCATTTGATGGTTTGAATAATGGTGTTCAT
    AATCGTATGATCCTACCTCTATTAACTCTTAAGAATGCACATATGTTCTTGATTTCGACT
    TACAATACAATGGCTTATAGCTCTTTTGAAAAATATGGTAAGTATACAGAAGCTGAACGA
    GAAGCATTTAAAGATAAAATTAAAGAAGTTGCTCACGCACAACAAACTTATCTTGACTTC
    TGGTCGCGTTTAGCATTGCCAAGCGTACGTGACCAATTACTCAAGAGTCAAAATAGGGTT
    CCAACACCTGTTTGGGATAACCAAAACTATCATAACGTCGAAGGTGTAAATCGTATGGGT
    TATGATAAGAATAATAAACCAATTGCACCTATTCGTGAATTATATGGACCTACTTGGCGT
    TATCATACTACAAATTGGTACATGGGAGCTATGGCATCTATTTTCCAAGATCCCAATAAT
    AATGACCAAGTTTATTTCATGGGAACAAATATGATTAGTCCGTTTGGTATTTCAGCCTTT
    ACTCACGAAACAACACACGTAAACGATAGAATGCTTTACTTCGGTGGGCATAGACACCGT
    CAAGGTACAGACGTTGAAGCCTATGCGCAAGGTATGTTGCAGACACCTGATAAATCTGGT
    AACGGTGAATATGGTGCTCTTGGTCTTAACATGGCTTATCATCGTGAAAATGACGGTGAC
    CAATGGTATAATTATGATCCAGATAAATTGAAAACTCGTGAAGATATCGACCGTTATATG
    AGAAATTATAATGATGCTCTTATGATGTTAGACCATCTTGAGGCTGATGCTGTTATCCCT
    AAATTACATGGTAATATTAGTCGATGGTTCAAGAAAATGGATAGACAATATCGCAAAAAT
    GGAGAGCTACATCAATTTGATAAAGTTCGTGAATTAACTGAAGATGAGAAGAAGAAAATT
    GTTATCAACAACATTGATGATTTAGTCAACAATAATTTGATGACAAAACATGGCGCTCCT
    AGTGACAGAACATATAATCCAGAAGATTTTGATAGTGCTTACGTAAATATTAATATGATG
    ACCGGTATCTATGGTGGTAATACTAGCCAAGGAGCACCTGGAGCTGCATCATTCAAGCAT
    AATACTTTCCGTATGTGGGGCTATTTTGGTTATGAAAATGGATTCATTAGTTATGCATCT
    AGCAAATATCAAGGCGAAGCTGACAAAACCAATAAAAAATTATTGGGTGATGATTTCATT
    ATCAAGAAAGTATCTAAGGATAAATTCAATAATCTTGAAGAGTGGAAGAAACAATACTTC
    AAAGATGTTAAGTCAAAAGCAGAAAAAGGATTTACTGCTATTGAAATTGATGGTCGTCAA
    ATTACAAATTATGCTCAGTTGAAAACTTTATTTGCTGAAGCTGTTCAAAAAGATATTGAT
    GGTATGTCAGATCCGAAAATTAAAGATCATTTCAAAAATACAGTAGACTTGAAATCCAAA
    GTATTCAAAGCCCTTCTTAAAAACACAGACGGTTTCTTTAATAAACTGTTTAAAGAAGAC
    ATTTAA
    60
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    240
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    420
    480
    540
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    660
    720
    780
    840
    900
    960
    1020
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    1140
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    1260
    1320
    1380
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    2160
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    2820
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    2940
    3000
    3060
    3120
    3180
    3240
    3300
    3360
    3420
    3480
    3540
    3600
    3660
    3720
    3780
    3840
    3900
    3960
    4020
    4080
    4140
    4200
    4260
    4320
    4380
    4440
    4500
    4560
    4620
    4680
    4740
    4800
    4860
    4920
    4980
    5040
    5100
    5160
    5220
    5280
    5340
    5400
    5406

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNINV200_RS05735 [old locus tag: SPNINV200_10710 ]
  • symbol: ZmpD
  • description: zinc metalloprotease D
  • length: 1801
  • theoretical pI: 5.43632
  • theoretical MW: 203015
  • GRAVY: -0.628484

⊟Function[edit | edit source]

  • TIGRFAM:
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 19.8)
  • TheSEED: see SPNINV200_10710
  • PFAM:
    no clan defined Peptidase_M26_C; M26 IgA1-specific Metallo-endopeptidase C-terminal region (PF07580; HMM-score: 826.5)
    and 4 more
    Peptidase_M26_N; M26 IgA1-specific Metallo-endopeptidase N-terminal region (PF05342; HMM-score: 253.9)
    G5 (CL0593) G5; G5 domain (PF07501; HMM-score: 35.3)
    no clan defined Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 19.8)
    YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 8.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 10
    • Extracellular Score: 0
    • Internal Helices: 2
  • DeepLocPro: Cell wall & surface
    • Cytoplasmic Score: 0.0006
    • Cytoplasmic Membrane Score: 0.0211
    • Cell wall & surface Score: 0.8757
    • Extracellular Score: 0.1026
  • SignalP: Signal peptide SP(Sec/SPI) length 35 aa
    • SP(Sec/SPI): 0.860775
    • TAT(Tat/SPI): 0.019935
    • LIPO(Sec/SPII): 0.012019
    • Cleavage Site: CS pos: 35-36. VGA-ST. Pr: 0.5872
  • predicted transmembrane helices (TMHMM): 3

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000054797 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSLLKKDKFSIRKIKGIVGSVFLGSLLFAPSVVGASTYHYLDYSSLTQTERDQLKQGRPDESKESYALDYEKDALPNTGSSQSIMTALGLLAIGSLIVIITKDNRNKKIATFLIVGATGLVTLSTASALNLNANIHESGRDGVLQISGYRYVGYLELDDKTVSSVSPASTVSPVEQPKVVTEKGEPEVQPALPEAVVTDKGEPEVQPTLPEAVVTDKGEPEVHEKPDYTQPIGANLVEPEVHEKLAYTESVGTTGMDENGNLIEPPVSDIPEYTESVGTTGVDENGNLIEPPVSDIPEYTESVGTTGVDENGNLIEPPVNDIPEYTEPISTVSEVASEREELPSLHTDIRTETIPKTTIEESDPSKFIGDDSVKEVGEDGERQIVTSYEELHGKKISEPVETVTILKEMKPKILVKGTKENPKEKTVPVLTLTKVTEDAMNRSANLNYELDNKDNAEISSIIAEIKDGDTVVKKVDLSKEKLTDAVQNLDLFKDYKIATTMIYDRGQGSETSKLDEKTLRLELKKVEIKNISSTNLVKVNDDGTEIPSDFMSEKPSDEDVKKMYLKITSRDNKVTRLAVDKIELVTEKEKELYKITASAQDLIQHVDPSKTRNEYIHYIEKPVPKVNNVYYNFNELVRDMQEHPNDEFKLGADLNATNVSAFGKSYVTKDFKGKLLSDGDNHYTIHNLSRPLFGNVIGGTIKNINLGNVDINMPWANQVAAVANIIKGGTTIENVKVKGNIVGKDWVSGFIDKIDNQGTLRNVAFIGNVTSVGDGGQFLTGIVGENWKGLVERAYVNANLIGKKAKAAGIAYWTQNEGNNNTVRQEGAIKKSIAKGTIQVTEAIESGGVVGSMKHHGSVEDSVSMMKVPNGEIFYGSSDIDYDDGYWTGDNVRRNYVVIGVSDGHSSYQRSKDKNRIRPISEEEAKSKIEATGITADKYEINEPVVNRLNRLTRREDEYKSTQDYKVDRDLAYRNIEKLQPFYNKEWIVNQGNKLAEDSNLAKKEVLSVTGMKDGQFVTDLSDIDHVMIHYADKTKEIKAVHQKESKVAQVREYSIDGLDDIVYTPNMVDKNRDQLIKDIKDRLATVELISPEVRALMDKRDTSRDPNANSDERKNGYIRDLYFEESFSETKANLDKLVKSLIENADHQLNSDEAAMKALVKKVDENKAKIVMALTYLNRYYDIKYGDMTIKNLMMFKPDFYGKSVDLLDFLIRIGSSERNIKGDRTLDAYRDMIGGTIGKSELHGFLDYNMRLFTNDTDLNDWFIHAAKNVYIVEPKTTNPDFVNKRHRAFDGLNNGVHNRMILPLLTLKNAHMFLISTYNTMAYSSFEKYGKYTEAEREAFKDKIKEVAHAQQTYLDFWSRLALPSVRDQLLKSQNRVPTPVWDNQNYHNVEGVNRMGYDKNNKPIAPIRELYGPTWRYHTTNWYMGAMASIFQDPNNNDQVYFMGTNMISPFGISAFTHETTHVNDRMLYFGGHRHRQGTDVEAYAQGMLQTPDKSGNGEYGALGLNMAYHRENDGDQWYNYDPDKLKTREDIDRYMRNYNDALMMLDHLEADAVIPKLHGNISRWFKKMDRQYRKNGELHQFDKVRELTEDEKKKIVINNIDDLVNNNLMTKHGAPSDRTYNPEDFDSAYVNINMMTGIYGGNTSQGAPGAASFKHNTFRMWGYFGYENGFISYASSKYQGEADKTNKKLLGDDFIIKKVSKDKFNNLEEWKKQYFKDVKSKAEKGFTAIEIDGRQITNYAQLKTLFAEAVQKDIDGMSDPKIKDHFKNTVDLKSKVFKALLKNTDGFFNKLFKEDI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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