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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 11-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae INV200
  • locus tag: SPNINV200_RS08415 [old locus tag: SPNINV200_15820 ]
  • pan locus tag?: PNEUPAN003189000
  • symbol: secA2
  • pan gene symbol?: secA-2
  • synonym:
  • product: accessory Sec system translocase SecA2

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNINV200_RS08415 [old locus tag: SPNINV200_15820 ]
  • symbol: secA2
  • product: accessory Sec system translocase SecA2
  • replicon: chromosome
  • strand: -
  • coordinates: 1606914..1609289
  • length: 2376
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_017593 (1606914..1609289) NCBI
  • BioCyc: SPNINV200_RS08415 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    ATGTGGAATAAGAATAGACAATTACGCAAAGTAAAAAAGATATTGAATCAAATTAATCGT
    AGAAAAGAGGAGATGGCCCTACTGACAGATGAAGAATTAGCAGCTAAGACGCAAGAATTT
    AAAAGAAGGCTGACTGCGGGAGAAACCCTAGATGATATTTTGGTTGAGGCTTTCGCTGTT
    GTCCGAGAGGCTGACAAACGAATTCTAGGGATGTTTCCTTATGATGTTCAAGTCATGGGT
    GGAATTGTAATTCATCAAGGAAATGTAGCTGAGATGAATACTGGTGAAGGGAAAACATTG
    ACTGCTACCTTACCTATTTATCTCAATGCTTTATCAGGACAAGGTGTGATTCTTGTGACA
    ACTAATTCTTATCTTGCTAAACGTGATGCAGAGGAAATGGGAAAGGTTTATGAATTTTTA
    GGATTAACTATTCGATTACCCTTTGCTGATGATGAGGAAGAAAAAATTACACCTAAAGAG
    AAAAAAGAAATATATAGTGCAGATATTGTGTATACAACCAATAGTGGATTAGGTTTTGAT
    TACCTGATTGATAATCTAGCGTCAAGTGAAGAACAAAAGTACATGCCTGAATTTAATTTT
    GTTTTAGTTGATGAGATTGATTCGGTGTTGCTAGACAGTGCTCAGACTCCACTTGTCATT
    TCGGGCTCACCTCGAGTCCAATCTAATTTTTATGGAATTATTGATACTTTGATGACAACT
    CTAGTAGATGGGGAAGATTATATATTTAAGGAAGAAAAAAAGGAAGTCTGGCTAACTAAT
    AAAGGTGCCAAGATTGCAGAAAAATTTCTTGGAATTGACAATCTTTATGCTGAAGAAAAT
    AATGTATTGGCTAGACATTTGGTCTTTGCTTTGCGAGCTCATACTCTATTTAAAAGGGAT
    AAGGATTATATTATCCGTAAAGGGGAAAAGGACCAGGAACTAGTTCTGTTGGATCAAGGA
    ACAGGGCGTCTAATGGAAATGACTAAACTTCAAGGAGGTCTCCATCAGGCTATTGAAGCC
    AAGGAACATGTCAAATTATCTCCTGAGACGCGGGCTATGGCATCGATCACCTATCAGAGT
    CTTTTTAAGATGTTTAATAAGATATCTGGTATGACAGGGACAGGTAAGGTCGCGGAAAAA
    GAGTTTATTGAAACTTACAATATGTCTGTAGTACGCATTCCAACCAATCGTCCGAGACAA
    CGGATTGACTATCCAGATAATCTATATATCACTTTACCTGAAAAAGTGTATGCATCCTTG
    GAGTACATCAAGCAATACCATGCTAAGGGAAATCCTTTACTCGTTTTTGTAGGCTCAGTT
    GAAATGTCTCAACTCTATTCGTCTCTCTTGTTTCGTGAAGGGATTGCCCATAATGTCCTA
    AATGCTAATAATGCGGCGCGTGAGGCTCAGATTATCTCCGAGTCAGGTCAGATGGGGGCT
    GTGACAGTGGCTACCTCTATGGCAGGACGTGGTACGGATATCAAGCTTGGTAAAGGAGTC
    GCAGAGCTTGGGGGCTTGATTGTTATTGGGACTGAGCGGATGGAAAGTCAGCGGATCGAC
    CTACAAATTCGTGGCCGTTCTGGTCGTCAGGGAGATCCTGGTATGAGTAAATTTTTTGTA
    TCCTTAGAGGATGATGTTATCAAGAAATTTGGTCCATCTTGGGTGCATAAAAAGTACAAA
    GACTATCAGGTTCAAGATATGACTCAACCGGAAGTATTGAAAGGTCGTAAATACCGGAAA
    CTAGTCGAAAAGGCTCAGCATGCCAGTGATAGTGCTGGACGTTCAGCACGTCGTCAGACT
    CTAGAATATGCTGAAAGTATGAATATACAACGGGATATAGTCTATAAAGAGAGAAATCGT
    CTAATAGATGGTTCTCGTGACTTAGAGGATGTTGTTGTGGATATCATTGAGAGATATACA
    GAAGAGGTAGCGGCTGATCACTATGCTAGTCGTGAATTACTGTTTCACTTTATTGTGACC
    AATATTAGTTTTCATGTTAAAGAGGTTCCAGATTATATAGATGTAACTGACAAAACTGCA
    GTTCGTAGCTTTATGAAGCAGGTGATTGATAAAGAACTTTCTGAAAAGAAAGAATTACTT
    AATCAACATGACTTATATGAACAGTTTTTACGACTTTCACTGCTTAAAGCCATTGATGAC
    AACTGGGTAGAGCAGGTAGACTATCTACAACAGCTATCCATGGCTATCGGTGGTCAATCT
    GCTAGTCAGAAAAATCCAATCGTAGAGTACTATCAAGAAGCCTACGCGGGCTTTGAAGCT
    ATGAAAGAACAGATTCATGCGGATATGGTGCGTAATCTCCTGATGGGGCTGGTTGAGGTC
    ACTCCAAAAGGTGAAATCGTGACTCATTTTCCATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2376

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNINV200_RS08415 [old locus tag: SPNINV200_15820 ]
  • symbol: SecA2
  • description: accessory Sec system translocase SecA2
  • length: 791
  • theoretical pI: 5.74215
  • theoretical MW: 89921.2
  • GRAVY: -0.363085

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein fate Protein and peptide secretion and trafficking accessory Sec system translocase SecA2 (TIGR03714; HMM-score: 1235.4)
    and 3 more
    Genetic information processing Protein fate Protein and peptide secretion and trafficking preprotein translocase, SecA subunit (TIGR00963; HMM-score: 775)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking accessory Sec system translocase SecA2 (TIGR04397; HMM-score: 754.1)
    accessory Sec system translocase SecA2 (TIGR04221; HMM-score: 515.9)
  • TheSEED: see SPNINV200_15820
  • PFAM:
    P-loop_NTPase (CL0023) SecA_DEAD; SecA DEAD-like domain (PF07517; HMM-score: 368)
    and 7 more
    no clan defined SecA_SW; SecA Wing and Scaffold domain (PF07516; HMM-score: 109.6)
    SecA_PP_bind; SecA preprotein cross-linking domain (PF01043; HMM-score: 99.1)
    P-loop_NTPase (CL0023) DEAD; DEAD/DEAH box helicase (PF00270; HMM-score: 30)
    ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 18.3)
    Helicase_C; Helicase conserved C-terminal domain (PF00271; HMM-score: 18.1)
    no clan defined Vta1; Vta1 like (PF04652; HMM-score: 13.3)
    DUF6429; Domain of unknown function (DUF6429) (PF20008; HMM-score: 12.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.94
    • Cytoplasmic Membrane Score: 2.06
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.6963
    • Cytoplasmic Membrane Score: 0.2625
    • Cell wall & surface Score: 0.0022
    • Extracellular Score: 0.0391
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003724
    • TAT(Tat/SPI): 0.000635
    • LIPO(Sec/SPII): 0.000805
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000267261 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MWNKNRQLRKVKKILNQINRRKEEMALLTDEELAAKTQEFKRRLTAGETLDDILVEAFAVVREADKRILGMFPYDVQVMGGIVIHQGNVAEMNTGEGKTLTATLPIYLNALSGQGVILVTTNSYLAKRDAEEMGKVYEFLGLTIRLPFADDEEEKITPKEKKEIYSADIVYTTNSGLGFDYLIDNLASSEEQKYMPEFNFVLVDEIDSVLLDSAQTPLVISGSPRVQSNFYGIIDTLMTTLVDGEDYIFKEEKKEVWLTNKGAKIAEKFLGIDNLYAEENNVLARHLVFALRAHTLFKRDKDYIIRKGEKDQELVLLDQGTGRLMEMTKLQGGLHQAIEAKEHVKLSPETRAMASITYQSLFKMFNKISGMTGTGKVAEKEFIETYNMSVVRIPTNRPRQRIDYPDNLYITLPEKVYASLEYIKQYHAKGNPLLVFVGSVEMSQLYSSLLFREGIAHNVLNANNAAREAQIISESGQMGAVTVATSMAGRGTDIKLGKGVAELGGLIVIGTERMESQRIDLQIRGRSGRQGDPGMSKFFVSLEDDVIKKFGPSWVHKKYKDYQVQDMTQPEVLKGRKYRKLVEKAQHASDSAGRSARRQTLEYAESMNIQRDIVYKERNRLIDGSRDLEDVVVDIIERYTEEVAADHYASRELLFHFIVTNISFHVKEVPDYIDVTDKTAVRSFMKQVIDKELSEKKELLNQHDLYEQFLRLSLLKAIDDNWVEQVDYLQQLSMAIGGQSASQKNPIVEYYQEAYAGFEAMKEQIHADMVRNLLMGLVEVTPKGEIVTHFP

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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