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SPN994038
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serotype 1

NCBI: 26-AUG-2017

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae OXC141
  • locus tag: SPNOXC08740 [new locus tag: SPNOXC_RS04740 ]
  • pan locus tag?: PNEUPAN001999000
  • symbol: pmrA
  • pan gene symbol?: pmrA
  • synonym:
  • product: multi-drug resistance efflux pump

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNOXC08740 [new locus tag: SPNOXC_RS04740 ]
  • symbol: pmrA
  • product: multi-drug resistance efflux pump
  • replicon: chromosome
  • strand: +
  • coordinates: 883998..885182
  • length: 1185
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    TTGATAATAATGGCAATCAGAACCAGCTTCTTAATCAAGTGCATATCCTTCTTGAGGGAG
    GTAGGCAAGATGACAGAGATTAACTGGAAGGATAATCTGCGCATTGCCTGGTTTGGTAAT
    TTTCTGACAGGAGCCAGTATTTCTTTGGTTGTACCCTTTATGCCCATCTTCGTGGAAAAT
    CTAGGTGTAGGGAGTGAGCAAGTCGCTTTTTATGCAGGCTTAGCAATTTCTGTCTCTGCT
    ATTTCCGCGGCGCTCTTTTCTCCTATTTGGGGTATTCTTGCTGACAAATACGGCCGAAAA
    CCCATGATGATTCGGGCAGGTCTTGCTATGACTATCACTATGGGAGGCTTGGCCTTTGTC
    CCAAATATCTATTGGTTAATCTTTCTTCGTTTACTAAACGGTGTATTTGCAGGTTTTGTT
    CCTAATGCAACGGCACTGATAGCCAGTCAGGTTCCAAAGGAGAAATCAGGCTCTGCCTTA
    GGTACTTTGTCTACAGGCGTAGTTGCAGGTACTCTAACTGGTCCCTTTATTGGTGGCTTT
    ATCAAGGAAGATTTTCAACCAGTAGCCAAGGAAAAGGCTATTCCAACAAAGGAATTATTT
    ACCTCGGTTAAATATCCCTATCTTTTGCTCAATCTCTTTTTAACCAGTTTTGTCATCCAA
    TTTTCAGCTCAATCGATTGGCCCTATTTTGGCTCTTTATGTACGCGACTTAGGGCAGACA
    GAGAATCTTCTTTTTGTCTCTGGTTTGATTGTGTCCAGTATGGGCTTTTCCAGCATGATG
    AGTGCAGGAGTCATGGGCAAGCTAGGTGACAAGGTGGGCAATCATCGTCTCTTGGTTGTC
    GCCCAGTTTTATTCAGTCATCATCTATCTCCTCTGTGCCAATGCCTCTAGCCCCCTTCAA
    CTAGGACTCTATCGTTTCCTCTTTGGATTGGGAACCGGTGCCTTGATTCCCGGGGTTAAT
    GCCCTACTCAGCAAAATGACTCCCAAAGCCGGCATTTCGAGGGTCTTTGCCTTCAATCAG
    GTATTCTTTTATCTGGGAGGTGTTGTTGGTCCCATGGCAGGTTCTGCAGTAGCAGGTCAA
    TTTGGCTACCATGCTGTCTTTTATGCGACGAGCCTTTGTGTTGCCTTTAGTTGTCTCTTT
    AACCTGATTCAATTTCGAACATTATTAAAAGTAAAGGAAATCTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1185

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNOXC08740 [new locus tag: SPNOXC_RS04740 ]
  • symbol: PmrA
  • description: multi-drug resistance efflux pump
  • length: 394
  • theoretical pI: 10.107
  • theoretical MW: 42422.2
  • GRAVY: 0.759898

⊟Function[edit | edit source]

  • TIGRFAM:
    multidrug resistance protein (TIGR00880; HMM-score: 116.1)
    and 14 more
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids MFS transporter, aromatic acid:H+ symporter (AAHS) family (TIGR00895; HMM-score: 91.2)
    Cellular processes Cellular processes Toxin production and resistance drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family (TIGR00711; HMM-score: 80.3)
    Metabolism Transport and binding proteins Other drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family (TIGR00711; HMM-score: 80.3)
    drug resistance transporter, Bcr/CflA subfamily (TIGR00710; HMM-score: 61)
    Metabolism Transport and binding proteins Cations and iron carrying compounds H+ Antiporter protein (TIGR00900; HMM-score: 51.9)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids phosphoglycerate transporter family protein (TIGR00881; HMM-score: 48.6)
    Metabolism Transport and binding proteins Cations and iron carrying compounds cation transport protein (TIGR00898; HMM-score: 44.5)
    Metabolism Transport and binding proteins Anions Na(+)-dependent inorganic phosphate cotransporter (TIGR00894; HMM-score: 41.8)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids D-galactonate transporter (TIGR00893; HMM-score: 38.8)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids MFS transporter, sialate:H+ symporter (SHS) family (TIGR00891; HMM-score: 33.5)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids sugar efflux transporter (TIGR00899; HMM-score: 29.2)
    Metabolism Transport and binding proteins Unknown substrate MFS transporter, metabolite:H+ symporter (MHS) family protein (TIGR00883; HMM-score: 27.5)
    synaptic vesicle protein SV2 (TIGR01299; HMM-score: 15.8)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids oxalate/formate antiporter family transporter (TIGR00890; HMM-score: 15.1)
  • TheSEED  :
    • Multidrug resistance efflux pump PmrA
    Virulence, Disease and Defense Resistance to antibiotics and toxic compounds Multidrug Resistance Efflux Pumps  Multidrug resistance efflux pump PmrA
  • PFAM:
    MFS (CL0015) MFS_1; Major Facilitator Superfamily (PF07690; HMM-score: 160.3)
    and 4 more
    Sugar_tr; Sugar (and other) transporter (PF00083; HMM-score: 57.4)
    MFS_1_like; MFS_1 like family (PF12832; HMM-score: 36.6)
    MFS_3; Transmembrane secretion effector (PF05977; HMM-score: 29.9)
    Glycine-zipper (CL0500) Rick_17kDa_Anti; Glycine zipper 2TM domain (PF05433; HMM-score: 9.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 10
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.006477
    • TAT(Tat/SPI): 0.000351
    • LIPO(Sec/SPII): 0.001701
  • predicted transmembrane helices (TMHMM): 10

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: CBW32531 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MIIMAIRTSFLIKCISFLREVGKMTEINWKDNLRIAWFGNFLTGASISLVVPFMPIFVENLGVGSEQVAFYAGLAISVSAISAALFSPIWGILADKYGRKPMMIRAGLAMTITMGGLAFVPNIYWLIFLRLLNGVFAGFVPNATALIASQVPKEKSGSALGTLSTGVVAGTLTGPFIGGFIKEDFQPVAKEKAIPTKELFTSVKYPYLLLNLFLTSFVIQFSAQSIGPILALYVRDLGQTENLLFVSGLIVSSMGFSSMMSAGVMGKLGDKVGNHRLLVVAQFYSVIIYLLCANASSPLQLGLYRFLFGLGTGALIPGVNALLSKMTPKAGISRVFAFNQVFFYLGGVVGPMAGSAVAGQFGYHAVFYATSLCVAFSCLFNLIQFRTLLKVKEI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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