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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 05-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae OXC141
  • locus tag: SPNOXC_RS01895 [old locus tags: SPNOXC03480 SPNOXC_03480 ]
  • pan locus tag?: PNEUPAN001107000
  • symbol: SPNOXC_RS01895
  • pan gene symbol?: luxS
  • synonym:
  • product: S-ribosylhomocysteine lyase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNOXC_RS01895 [old locus tags: SPNOXC03480 SPNOXC_03480 ]
  • symbol: SPNOXC_RS01895
  • product: S-ribosylhomocysteine lyase
  • replicon: chromosome
  • strand: -
  • coordinates: 340891..341373
  • length: 483
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_017592 (340891..341373) NCBI
  • BioCyc: SPNOXC_RS01895 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0309 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    ATGTCAAAAGAAGTTATTGTCGAAAGTTTTGAACTTGACCACACCATTGTCAAAGCACCC
    TATGTTCGCTTGATTGGGGAAGAAACAGGACCCAAAGGAGACATCATCTCCAATTATGAT
    ATTCGCTTGGTGCAACCAAACGAAGACTCTATCCCTACTGCCGGCCTTCACACTATCGAG
    CACCTCTTAGCCAAACTCATCCGTACCCGCATTGACGGCATGATTGACTGTTCACCATTT
    GGTTGCCGCACAGGCTTCCACATGATTATGTGGGGACGTCACACCAGTGCTAAAATCGCA
    GCTGTTATCAAGGATTCGCTCAAGGAAATCGCTGAAACTACTACTTGGGAAGATGTCCCA
    GGGACAACCATCGAATCTTGCGGAAACTACAAGGACCACAGCCTCTTCTCTGCTAAAGAA
    TGGGCAAAACTCATCTTGGAACAAGGGATTTCAGATGATGCCTTTGAACGTCATGTGATT
    TAA
    60
    120
    180
    240
    300
    360
    420
    480
    483

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNOXC_RS01895 [old locus tags: SPNOXC03480 SPNOXC_03480 ]
  • symbol: SPNOXC_RS01895
  • description: S-ribosylhomocysteine lyase
  • length: 160
  • theoretical pI: 5.26106
  • theoretical MW: 17923.4
  • GRAVY: -0.173125

⊟Function[edit | edit source]

  • reaction:
    EC 4.4.1.21?  ExPASy
    S-ribosylhomocysteine lyase S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione
  • TIGRFAM:
  • TheSEED: see SPNOXC03480
  • PFAM:
    Peptidase_ME (CL0094) LuxS; S-Ribosylhomocysteinase (LuxS) (PF02664; HMM-score: 177.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9894
    • Cytoplasmic Membrane Score: 0.0004
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0101
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003523
    • TAT(Tat/SPI): 0.000216
    • LIPO(Sec/SPII): 0.000447
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000032550 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSKEVIVESFELDHTIVKAPYVRLIGEETGPKGDIISNYDIRLVQPNEDSIPTAGLHTIEHLLAKLIRTRIDGMIDCSPFGCRTGFHMIMWGRHTSAKIAAVIKDSLKEIAETTTWEDVPGTTIESCGNYKDHSLFSAKEWAKLILEQGISDDAFERHVI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Uwe H Stroeher, Adrienne W Paton, A David Ogunniyi, James C Paton
Mutation of luxS of Streptococcus pneumoniae affects virulence in a mouse model.
Infect Immun: 2003, 71(6);3206-12
[PubMed:12761100] [WorldCat.org] [DOI] (P p)Susana Romao, Guido Memmi, Marco R Oggioni, Marie-Claude Trombe
LuxS impacts on LytA-dependent autolysis and on competence in Streptococcus pneumoniae.
Microbiology (Reading): 2006, 152(Pt 2);333-341
[PubMed:16436421] [WorldCat.org] [DOI] (P p)Claudia Trappetti, Adam J Potter, Adrienne W Paton, Marco R Oggioni, James C Paton
LuxS mediates iron-dependent biofilm formation, competence, and fratricide in Streptococcus pneumoniae.
Infect Immun: 2011, 79(11);4550-8
[PubMed:21875962] [WorldCat.org] [DOI] (I p)

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