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serotype 4
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serotype 2
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serotype 19A
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serotype 19F
670-6B
serotype 6B
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serotype 6A
70585
serotype 5
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serotype 3
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serotype 11A
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serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae P1031
  • locus tag: SPP_1100 [new locus tag: SPP_RS05450 ]
  • pan locus tag?: PNEUPAN002243000
  • symbol: SPP_1100
  • pan gene symbol?: prs2
  • synonym:
  • product: ribose-Phosphate pyrophosphokinase (rppk) (phosphoribosylpyrophosphate synthetase) (p-rib-pp synthetase) (prpp synthetase)

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPP_1100 [new locus tag: SPP_RS05450 ]
  • symbol: SPP_1100
  • product: ribose-Phosphate pyrophosphokinase (rppk) (phosphoribosylpyrophosphate synthetase) (p-rib-pp synthetase) (prpp synthetase)
  • replicon: chromosome
  • strand: -
  • coordinates: 1007685..1008644
  • length: 960
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGTCAGATAGAAAAAACATGAAACTTTTCGCACTCAACTCTAACCAAGAGATTGCACAA
    AAAATTGCCCAAGCTGTTGGTGTCCCACTTGGAAAACTATCATCACGTCAATTTTCAGAC
    GGAGAAATCCAAGTAAATATCGAAGAAAGTGTCCGTGGTTATGATGTTTACATCATCCAA
    TCAACAAGTTTCCCTGTCAACAACCACCTAATGGAATTGTTAATCATGGTCGATGCTTGT
    GTGCGTGCAAGTGCCCACAGTATCAACGTTGTCCTTCCATATTTTGGCTATGCACGTCAA
    GACCGCATTGCTTGTCCTCGTGAGCCACTTACAGCAAAACTAGTTGCCAATATGCTGGTT
    AAGGCTGGAGTTGATCGTATCCTGACTCTTGATTTGCATGCCGTTCAGGTTCAAGGTTTC
    TTTGATATTCCAGTGGATAATCTTTTCACTGTTCCCCTATTCGCAAAACATTACTGCGAT
    AAAGGATTGCTTGGTTCAGATGTTGTTGTCGTTAGCCCTAAAAATTCAGGTGTCAAACGT
    GCGCGTAGCCTGGCTGAATATCTTGATGCTCCTATCGCCATTATCGACTACCCTCAAGAC
    GATGCAACTCGTAACGAAGGTTATATTATTGGTGATGTTGAAGGTAAGAAAGCTATCTTG
    ATTGATGATATTTTAAATACAGGACGTACCTTCTCTGAAGCTTCTAAAATCGTTGAACGT
    GAAGGAGCTACAGAAATTTATGCTGTTTCTAGCCACGGTCTCTTCGTCGAGGGAGCTGCT
    GAGCTTCTTGACAATACTAATATTAAAGAAATTCTTGTGACTGATTCAGTAGCAACAAAA
    GAAAAAACTCCTAAAAATGTATGCTATATCACTGCTAGTGAGTTAATTGGTGATGCTATC
    GTACGTATTCACGAAAGAAAACCAGTCAGCCCACTCTTTGCCTACAATAAAAAGAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPP_1100 [new locus tag: SPP_RS05450 ]
  • symbol: SPP_1100
  • description: ribose-Phosphate pyrophosphokinase (rppk) (phosphoribosylpyrophosphate synthetase) (p-rib-pp synthetase) (prpp synthetase)
  • length: 319
  • theoretical pI: 6.26072
  • theoretical MW: 35125.1
  • GRAVY: -0.0225705

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.6.1?  ExPASy
    Ribose-phosphate diphosphokinase ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis ribose-phosphate diphosphokinase (TIGR01251; EC 2.7.6.1; HMM-score: 341.2)
    and 6 more
    Cellular processes Cellular processes DNA transformation comF family protein (TIGR00201; HMM-score: 23.5)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis orotate phosphoribosyltransferase (TIGR01367; EC 2.4.2.10; HMM-score: 21.4)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis orotate phosphoribosyltransferase (TIGR00336; EC 2.4.2.10; HMM-score: 19)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides hypoxanthine phosphoribosyltransferase (TIGR01203; EC 2.4.2.8; HMM-score: 16.9)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides adenine phosphoribosyltransferase (TIGR01090; EC 2.4.2.7; HMM-score: 14)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides uracil phosphoribosyltransferase (TIGR01091; EC 2.4.2.9; HMM-score: 12.5)
  • TheSEED  :
    • Ribose-phosphate pyrophosphokinase (EC 2.7.6.1)
    Carbohydrates Central carbohydrate metabolism Pentose phosphate pathway  Ribose-phosphate pyrophosphokinase (EC 2.7.6.1)
    and 1 more
    Nucleosides and Nucleotides Purines De Novo Purine Biosynthesis  Ribose-phosphate pyrophosphokinase (EC 2.7.6.1)
  • PFAM:
    PRTase-like (CL0533) Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase (PF13793; HMM-score: 165.5)
    and 4 more
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain (PF14572; HMM-score: 83)
    Pribosyltran; Phosphoribosyl transferase domain (PF00156; HMM-score: 45)
    HAD (CL0137) Hydrolase_3; haloacid dehalogenase-like hydrolase (PF08282; HMM-score: 14.2)
    PRTase-like (CL0533) UPRTase; Uracil phosphoribosyltransferase (PF14681; HMM-score: 12.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.67
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.15
    • Extracellular Score: 0.17
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.01365
    • TAT(Tat/SPI): 0.005901
    • LIPO(Sec/SPII): 0.001647
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACO21424 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSDRKNMKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQVNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDACVRASAHSINVVLPYFGYARQDRIACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCDKGLLGSDVVVVSPKNSGVKRARSLAEYLDAPIAIIDYPQDDATRNEGYIIGDVEGKKAILIDDILNTGRTFSEASKIVEREGATEIYAVSSHGLFVEGAAELLDNTNIKEILVTDSVATKEKTPKNVCYITASELIGDAIVRIHERKPVSPLFAYNKKK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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