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serotype 4
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HU-OH
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Hu15
serotype 19A
Hu17
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serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 22-NOV-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae P1031
  • locus tag: SPP_RS00920 [old locus tag: SPP_0188 ]
  • pan locus tag?: PNEUPAN000796000
  • symbol: mnmG
  • pan gene symbol?: mnmG
  • synonym:
  • product: tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPP_RS00920 [old locus tag: SPP_0188 ]
  • symbol: mnmG
  • product: tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG
  • replicon: chromosome
  • strand: +
  • coordinates: 157169..159082
  • length: 1914
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    ATGACTTATCATTTTACTGAAGAATACGATATTATTGTAATTGGTGCGGGACACGCTGGG
    GTTGAGGCTTCCTTGGCCGCTAGCCGTATGGGCTGTAAGGTCCTGCTTGCGACCATCAAT
    ATTGAAATGCTGGCTTTCATGCCTTGTAATCCCTCTATCGGTGGTTCTGCTAAGGGGATT
    GTCGTACGTGAAGTCGATGCCCTCGGTGGCGAGATGGCCAAGACCATTGACAAGACTTAC
    ATCCAGATGAAGATGCTCAACACAGGGAAGGGCCCAGCCGTTCGTGCCCTTCGTGCGCAG
    GCTGATAAGGAACTTTACTCTAAGGAAATGCGCAAGACAGTTGAAAATCAAGAAAATCTG
    ACCCTTCGTCAAACCATGATTGATGAGATTTTGGTGGAAGATGGCAAGGTTGTCGGTGTG
    CGTACAGCCACCCATCAAGAATATGCTGCTAAGGCTGTTATTGTGACGACAGGGACTGCT
    CTCCGTGGGGAAATTATCATCGGAGACCTCAAGTACTCATCAGGTCCTAACCACAGCTTG
    GCTTCTATTAACCTAGCTGACAATCTCAAGGAACTGGGTCTCGAAATCGGTCGTTTCAAG
    ACAGGAACCCCTCCACGTGTCAAGGCTTCTTCTATCAATTACGATGTGACGGAAATTCAG
    CCAGGAGACGAAGTGCCTAATCATTTCTCATACACTTCACGTGATGAGGATTATGTCAAA
    GATCAAGTGCCATGCTGGTTGACCTATACCAATGGTACCAGTCATGAGATTATCCAAAAC
    AACCTCCACCGTGCGCCTATGTTTACAGGTGTGGTCAAGGGAGTGGGGCCTCGTTACTGT
    CCGTCGATTGAAGACAAGATTGTGCGCTTTGCGGACAAGGAACGTCACCAACTCTTCCTT
    GAGCCAGAAGGGCGCAATACTGAGGAAGTCTATGTTCAAGGACTTTCAACCAGTCTGCCT
    GAGGATGTCCAGCGTGACTTGGTTCATTCCATCAAAGGTTTGGAAAATGCAGAGATGATG
    CGGACAGGTTATGCTATTGAGTATGATATGGTCTTGCCTCATCAGTTGCGTGCGACTTTG
    GAAACCAAGAAAATCTCAGGTCTCTTCACTGCTGGTCAGACAAATGGAACATCAGGTTAT
    GAAGAAGCTGCTGGCCAAGGGATTATCGCGGGTATCAATGCGGCTCTGAAAATCCAAGGT
    AAACCTGAGTTGATTCTAAAACGAAGTGACGGTTATATCGGGGTGATGATCGACGACTTG
    GTGACCAAGGGAACCATTGAACCTTACCGTCTCTTGACCAGTCGTGCTGAATACCGTCTC
    ATTCTTCGTCATGACAATGCTGATATGCGCTTGACTGAGATGGGACGCGAGATTGGCCTT
    GTGGATGATGAACGCTGGGCTCGTTTTGAAATCAAGAAAAATCAATTTGATAATGAGATG
    AAACGCCTAGACAGTATCAAACTCAAGCCAGTCAAGGAAACCAATGCTAAGGTTGAGGAA
    ATGGGCTTCAAGCCGTTGACAGATGCGGTGACAGCCAAAGAATTCCTTCGCCGTCCAGAA
    GTTTCTTACCAAGATGTGGTGGCCTTCATCGGACCAGCTGCAGAAGACTTGGATGACAAG
    ATTATCGAATTGATTGAAACAGAAATCAAGTACGAAGGCTATATTTCAAAAGCCATGGAT
    CAGGTTGCCAAGATGAAACGTATGGAAGAAAAACGCATTCCAGCCAATATTGACTGGGAT
    GACATCGATTCTATTGCGACGGAAGCTCGTCAGAAGTTCAAACTCATCAATCCAGAAACC
    ATCGGCCAAGCCAGCCGTATTTCGGGAGTAAACCCAGCAGATATTTCTATTTTGATGGTG
    TATCTGGAAGGTAAAAATCGTAGTATTTCTAAAACTCTTCAAAAATCAAAATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1914

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPP_RS00920 [old locus tag: SPP_0188 ]
  • symbol: MnmG
  • description: tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG
  • length: 637
  • theoretical pI: 5.76268
  • theoretical MW: 71045.9
  • GRAVY: -0.366562

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA (TIGR00136; HMM-score: 911.5)
    and 26 more
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA:m(5)U-54 methyltransferase (TIGR00137; EC 2.1.1.74; HMM-score: 69.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll geranylgeranyl reductase family (TIGR02032; EC 1.3.1.-; HMM-score: 28.1)
    Metabolism Energy metabolism Electron transport thioredoxin-disulfide reductase (TIGR01292; EC 1.8.1.9; HMM-score: 24.5)
    Cellular processes Cellular processes Detoxification alkyl hydroperoxide reductase subunit F (TIGR03140; EC 1.8.1.-; HMM-score: 18.9)
    Cellular processes Cellular processes Adaptations to atypical conditions alkyl hydroperoxide reductase subunit F (TIGR03140; EC 1.8.1.-; HMM-score: 18.9)
    Metabolism Energy metabolism Amino acids and amines sarcosine oxidase, alpha subunit family (TIGR01372; HMM-score: 17.3)
    putative alkyl hydroperoxide reductase F subunit (TIGR03143; EC 1.6.4.-; HMM-score: 16.4)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridine nucleotides L-aspartate oxidase (TIGR00551; EC 1.4.3.16; HMM-score: 14.5)
    Metabolism Energy metabolism Amino acids and amines sarcosine oxidase, monomeric form (TIGR01377; HMM-score: 14.4)
    dihydrolipoyl dehydrogenase (TIGR01350; EC 1.8.1.4; HMM-score: 14.2)
    Unknown function Enzymes of unknown specificity flavoprotein, HI0933 family (TIGR00275; HMM-score: 13.6)
    Metabolism Energy metabolism TCA cycle succinate dehydrogenase, flavoprotein subunit (TIGR01816; HMM-score: 13.6)
    Unknown function Enzymes of unknown specificity GMC family mycofactocin-associated oxidreductase (TIGR04542; EC 1.-.-.-; HMM-score: 13.5)
    Unknown function Enzymes of unknown specificity putative bacillithiol system oxidoreductase, YpdA family (TIGR04018; EC 1.8.-.-; HMM-score: 13.2)
    Metabolism Energy metabolism Anaerobic glycerol-3-phosphate dehydrogenase, anaerobic, B subunit (TIGR03378; EC 1.1.5.3; HMM-score: 11.9)
    Metabolism Energy metabolism Electron transport glutathione-disulfide reductase (TIGR01424; EC 1.8.1.7; HMM-score: 11.5)
    thioredoxin and glutathione reductase (TIGR01438; EC 1.6.4.-; HMM-score: 11.4)
    lycopene cyclase family protein (TIGR01790; HMM-score: 11.1)
    Metabolism Energy metabolism TCA cycle succinate dehydrogenase or fumarate reductase, flavoprotein subunit (TIGR01812; HMM-score: 9.9)
    Metabolism Energy metabolism Anaerobic succinate dehydrogenase or fumarate reductase, flavoprotein subunit (TIGR01812; HMM-score: 9.9)
    Metabolism Energy metabolism Aerobic succinate dehydrogenase or fumarate reductase, flavoprotein subunit (TIGR01812; HMM-score: 9.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin precorrin 3B synthase CobZ (TIGR02485; HMM-score: 9.8)
    Cellular processes Cellular processes Detoxification mercury(II) reductase (TIGR02053; EC 1.16.1.1; HMM-score: 9.4)
    FAD dependent oxidoreductase TIGR03364 (TIGR03364; HMM-score: 9.3)
    Metabolism Energy metabolism Electron transport flavocytochrome c (TIGR01813; HMM-score: 8.8)
    squalene-associated FAD-dependent desaturase (TIGR03467; HMM-score: 7)
  • TheSEED: see SPP_0188
  • PFAM:
    NADP_Rossmann (CL0063) GIDA; Glucose inhibited division protein A (PF01134; HMM-score: 551.7)
    and 10 more
    no clan defined GIDA_C; tRNA modifying enzyme MnmG/GidA C-terminal domain (PF13932; HMM-score: 254)
    NADP_Rossmann (CL0063) Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase (PF07992; HMM-score: 27.5)
    FAD_oxidored; FAD dependent oxidoreductase (PF12831; HMM-score: 24.1)
    FAD_binding_2; FAD binding domain (PF00890; HMM-score: 22.1)
    Pyr_redox_3; Pyridine nucleotide-disulphide oxidoreductase (PF13738; HMM-score: 18.9)
    HI0933_like; HI0933-like protein (PF03486; HMM-score: 18.7)
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase (PF00070; HMM-score: 16.5)
    no clan defined YlqD; YlqD protein (PF11068; HMM-score: 16.2)
    NADP_Rossmann (CL0063) AlaDh_PNT_C; Alanine dehydrogenase/PNT, C-terminal domain (PF01262; HMM-score: 15.5)
    DAO; FAD dependent oxidoreductase (PF01266; HMM-score: 12.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9013
    • Cytoplasmic Membrane Score: 0.0119
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0867
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.025987
    • TAT(Tat/SPI): 0.008923
    • LIPO(Sec/SPII): 0.008784
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000220964 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MTYHFTEEYDIIVIGAGHAGVEASLAASRMGCKVLLATINIEMLAFMPCNPSIGGSAKGIVVREVDALGGEMAKTIDKTYIQMKMLNTGKGPAVRALRAQADKELYSKEMRKTVENQENLTLRQTMIDEILVEDGKVVGVRTATHQEYAAKAVIVTTGTALRGEIIIGDLKYSSGPNHSLASINLADNLKELGLEIGRFKTGTPPRVKASSINYDVTEIQPGDEVPNHFSYTSRDEDYVKDQVPCWLTYTNGTSHEIIQNNLHRAPMFTGVVKGVGPRYCPSIEDKIVRFADKERHQLFLEPEGRNTEEVYVQGLSTSLPEDVQRDLVHSIKGLENAEMMRTGYAIEYDMVLPHQLRATLETKKISGLFTAGQTNGTSGYEEAAGQGIIAGINAALKIQGKPELILKRSDGYIGVMIDDLVTKGTIEPYRLLTSRAEYRLILRHDNADMRLTEMGREIGLVDDERWARFEIKKNQFDNEMKRLDSIKLKPVKETNAKVEEMGFKPLTDAVTAKEFLRRPEVSYQDVVAFIGPAAEDLDDKIIELIETEIKYEGYISKAMDQVAKMKRMEEKRIPANIDWDDIDSIATEARQKFKLINPETIGQASRISGVNPADISILMVYLEGKNRSISKTLQKSK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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