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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 22-NOV-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae P1031
  • locus tag: SPP_RS13730 [old locus tag: SPP_0745 ]
  • pan locus tag?: PNEUPAN001658000
  • symbol: SPP_RS13730
  • pan gene symbol?: —
  • synonym:
  • product: winged helix-turn-helix domain-containing protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPP_RS13730 [old locus tag: SPP_0745 ]
  • symbol: SPP_RS13730
  • product: winged helix-turn-helix domain-containing protein
  • replicon: chromosome
  • strand: -
  • coordinates: 680339..680845
  • length: 507
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_012467 (680339..680845) NCBI
  • BioCyc:
  • MicrobesOnline: see SPP_0745
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    ATGAAATCAATTAAAGAAGACATCCAAACCATCAAAACACTTTTAAAAGACTCTCGTACA
    GCTAAATATCATAAACGCCTTCAAATCGTTCTATTTCGTCTGATGGGCAAATCTTATAAA
    GAGATTATAGAGCTTTTAGACTGTAATCAAACAACGATTTGGCGAAATGTAAAAAAATAT
    GAGGAGTTCGGACTCGACTCTCTCCTTCAAGAAACACGTGGTGGTCGTAACCATGCATAT
    ATGACAGTTGAGGAAGAGAAAGCCTTTCTTGCCCGCCATTTGAAGGCTACAGAGGCAGGA
    GAATTTGTTACAATTGATGCCTTATTTCAGGCTTATAAAAAGGAGTTAGGTCATTCCTAC
    ACACGTGATGCCTTCTATCAACTGTTGAAGCGCCATGGTTGGCGAAATATTACGCCACGT
    CCAGAACATCCTAAGAAAGCAGACGCTCAAACCATTGTTGCGTCTAAAAATAAAATCTCA
    ATTCAAGAAGACAAGAAAGCGTTTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    507

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPP_RS13730 [old locus tag: SPP_0745 ]
  • symbol: SPP_RS13730
  • description: winged helix-turn-helix domain-containing protein
  • length: 168
  • theoretical pI: 10.1893
  • theoretical MW: 19717.6
  • GRAVY: -0.705952

⊟Function[edit | edit source]

  • TIGRFAM:
    RNA polymerase sigma factor, sigma-70 family (TIGR02937; HMM-score: 18.3)
    and 2 more
    RNA polymerase sigma factor RpoE (TIGR02939; HMM-score: 14.4)
    Signal transduction Regulatory functions DNA interactions biotin operon repressor (TIGR00122; HMM-score: 12.2)
  • TheSEED: see SPP_0745
  • PFAM:
    HTH (CL0123) HTH_33; Winged helix-turn helix (PF13592; HMM-score: 47.5)
    HTH_23; Homeodomain-like domain (PF13384; HMM-score: 38.5)
    and 7 more
    HTH_28; Helix-turn-helix domain (PF13518; HMM-score: 35.9)
    HTH_29; Winged helix-turn helix (PF13551; HMM-score: 22.5)
    HTH_32; Homeodomain-like domain (PF13565; HMM-score: 16.9)
    HTH_11; HTH domain (PF08279; HMM-score: 15.8)
    Sigma70_r4_2; Sigma-70, region 4 (PF08281; HMM-score: 15.8)
    Terminase_5; Putative ATPase subunit of terminase (gpP-like) (PF06056; HMM-score: 14.9)
    HTH_38; Helix-turn-helix domain (PF13936; HMM-score: 14.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.8883
    • Cytoplasmic Membrane Score: 0.0037
    • Cell wall & surface Score: 0.0175
    • Extracellular Score: 0.0906
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004946
    • TAT(Tat/SPI): 0.000333
    • LIPO(Sec/SPII): 0.001304
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000835780 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKSIKEDIQTIKTLLKDSRTAKYHKRLQIVLFRLMGKSYKEIIELLDCNQTTIWRNVKKYEEFGLDSLLQETRGGRNHAYMTVEEEKAFLARHLKATEAGEFVTIDALFQAYKKELGHSYTRDAFYQLLKRHGWRNITPRPEHPKKADAQTIVASKNKISIQEDKKAF

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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