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serotype 4
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serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
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A66
serotype 3
AP200
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ASP0581
serotype 12F
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serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 26-OCT-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: SPR_RS01855 [old locus tag: spr0362 ]
  • pan locus tag?: PNEUPAN001269000
  • symbol: tig
  • pan gene symbol?: tig
  • synonym:
  • product: trigger factor

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPR_RS01855 [old locus tag: spr0362 ]
  • symbol: tig
  • product: trigger factor
  • replicon: chromosome
  • strand: +
  • coordinates: 359944..361227
  • length: 1284
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGTCTGTATCATTTGAAAACAAAGAAACAAACCGTGGTGTCTTGACTTTCACTATCTCT
    CAAGACCAAATCAAACCAGAATTGGACCGTGTCTTCAAGTCAGTGAAGAAATCTCTTAAT
    GTTCCAGGTTTCCGTAAAGGTCACCTTCCACGCCCTATCTTCGACCAAAAATTTGGTGAA
    GAAGCTCTTTATCAAGATGCAATGAACGCACTTTTGCCAAACGCTTATGAAGCAGCTGTA
    AAAGAAGCTGGTCTTGAAGTGGTTGCCCAACCAAAAATTGACGTAACTTCAATGGAAAAA
    GGTCAAGACTGGGTTATCACTGCTGAAGTCGTTACAAAACCTGAAGTAAAATTGGGTGAC
    TACAAAAACCTTGAAGTATCAGTTGATGTAGAAAAAGAAGTAACTGACGCTGATGTCGAA
    GAGCGTATCGAACGCGAACGCAACAACCTGGCTGAATTGGTTATCAAGGAAGCTGCTGCT
    GAAAACGGCGACACTGTTGTGATCGACTTCGTTGGTTCTATCGACGGTGTTGAATTTGAC
    GGTGGAAAAGGTGAAAACTTCTCACTTGGACTTGGTTCAGGTCAATTCATCCCTGGTTTC
    GAAGACCAATTGGTAGGTCACTCAGCTGGCGAAACCGTTGATGTTATCGTAACATTCCCA
    GAAGACTACCAAGCAGAAGACCTTGCAGGTAAAGAAGCTAAATTCGTGACAACTATCCAC
    GAAGTAAAAGCTAAAGAAGTTCCAGCTCTTGACGATGAACTTGCAAAAGACATTGATGAA
    GAAGTTGAAACACTTGCTGACTTGAAAGAAAAATACCGCAAAGAATTGGCTGCTGCTAAA
    GAAGAAACTTACAAAGATGCAGTTGAAGGTGCAGCAATTGATACAGCTGTAGAAAACGCT
    GAAATCGTAGAACTTCCAGAAGAAATGATCCATGAAGAAGTTCACCGTTCAGTAAATGAA
    TTCCTTGGGAACTTGCAACGTCAAGGGATCAACCCTGACATGTACTTCCAAATCACTGGA
    ACTACTCAAGAAGACCTTCACAACCAATACCAAGCAGAAGCTGAGTCACGTACTAAGACT
    AACCTTGTTATCGAAGCAGTTGCCAAAGCTGAAGGATTTGATGCTTCAGAAGAAGAAATA
    CAAAAAGAAGTTGAGCAATTGGCAGCAGACTACAACATGGAAGTTGCACAAGTTCAAAAC
    TTGCTTTCAGCTGACATGTTGAAACATGATATCACTATCAAAAAAGCTGTTGAATTGATC
    ACAAGCACAGCAACAGTAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1284

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPR_RS01855 [old locus tag: spr0362 ]
  • symbol: Tig
  • description: trigger factor
  • length: 427
  • theoretical pI: 4.15295
  • theoretical MW: 47297.4
  • GRAVY: -0.423653

⊟Function[edit | edit source]

  • reaction:
    EC 5.2.1.8?  ExPASy
    Peptidylprolyl isomerase Peptidylproline (omega=180) = peptidylproline (omega=0)
  • TIGRFAM:
    Genetic information processing Protein fate Protein folding and stabilization trigger factor (TIGR00115; EC 5.2.1.8; HMM-score: 427.1)
    and 1 more
    Cellular processes Cellular processes Biosynthesis of natural products nif11-like leader peptide domain (TIGR03798; HMM-score: 8.7)
  • TheSEED: see spr0362
  • PFAM:
    Trigger_C (CL0262) Trigger_C; Bacterial trigger factor protein (TF) C-terminus (PF05698; HMM-score: 148.4)
    no clan defined Trigger_N; Bacterial trigger factor protein (TF) (PF05697; HMM-score: 135)
    and 6 more
    FKBP (CL0487) FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase (PF00254; HMM-score: 58.2)
    HTH (CL0123) MADF_DNA_bdg; Alcohol dehydrogenase transcription factor Myb/SANT-like (PF10545; HMM-score: 17.9)
    S15_NS1 (CL0600) WHEP-TRS; WHEP-TRS domain (PF00458; HMM-score: 13)
    no clan defined Focal_AT; Focal adhesion targeting region (PF03623; HMM-score: 11.4)
    Trigger_C (CL0262) SurA_N; SurA N-terminal domain (PF09312; HMM-score: 10.9)
    HTH (CL0123) PqqD; Coenzyme PQQ synthesis protein D (PqqD) (PF05402; HMM-score: 8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003942
    • TAT(Tat/SPI): 0.000517
    • LIPO(Sec/SPII): 0.001525
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSVSFENKETNRGVLTFTISQDQIKPELDRVFKSVKKSLNVPGFRKGHLPRPIFDQKFGEEALYQDAMNALLPNAYEAAVKEAGLEVVAQPKIDVTSMEKGQDWVITAEVVTKPEVKLGDYKNLEVSVDVEKEVTDADVEERIERERNNLAELVIKEAAAENGDTVVIDFVGSIDGVEFDGGKGENFSLGLGSGQFIPGFEDQLVGHSAGETVDVIVTFPEDYQAEDLAGKEAKFVTTIHEVKAKEVPALDDELAKDIDEEVETLADLKEKYRKELAAAKEETYKDAVEGAAIDTAVENAEIVELPEEMIHEEVHRSVNEFLGNLQRQGINPDMYFQITGTTQEDLHNQYQAEAESRTKTNLVIEAVAKAEGFDASEEEIQKEVEQLAADYNMEVAQVQNLLSADMLKHDITIKKAVELITSTATVK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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