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serotype 1

NCBI: 25-NOV-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: SPR_RS04850 [old locus tag: spr0969 ]
  • pan locus tag?: PNEUPAN002198000
  • symbol: SPR_RS04850
  • pan gene symbol?: nikS
  • synonym:
  • product: ATP-grasp domain-containing protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPR_RS04850 [old locus tag: spr0969 ]
  • symbol: SPR_RS04850
  • product: ATP-grasp domain-containing protein
  • replicon: chromosome
  • strand: +
  • coordinates: 951138..952337
  • length: 1200
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGGTCAAAATAGCAATCATCAATCAATTTTCACCTAGAGTTTGTGATTATAAAGCGATT
    AAAGAATTAGAAGATAAAAAATATGAAATTGAAATTTTCACAAAAGCTAGATTTAAATCT
    TACTATGAGGATTCAAAGTTTAAATGTTATTTCTATGATAATCTTTTGGATAACCAAAAT
    TATATATTTGATATTATAGATTCACATTCAAAAAAACCATTTACCTACATAGTTGCAACT
    CATGAATTTGATATAGTTTTGGCTGCAAAGATAAGAAAGTTATTGGGAATATCTGGACAA
    AACATTGATAGTGCTAATGGCTTTAGAGATAAATATATAATGAAAAAATATTTAGAAAAA
    GCAGTATCGTTACCAAAATATGCTGAAATTAATGATTGTGTAGATTTAATTGAATTTACT
    GATAACAAAAAATATCCATTTGTAGTGAAACCTAGACTTGGTGCAGGATCAATTGGTGTA
    ACAATAATACAAAATAAATCTGAATTAAAAGATTTTATTAGTAGTCCTCTAAGTCAAAAT
    TTAATGGTTGAAACTTTCACAAATGGGGAGATGTACCATGTGGATGGTTTATTTAAAGAT
    AATGAAATGCTGTTATATTCTGTTTCAAAATATTTCAATGATTGTTTATCGTTTAAAACT
    AATACACCGCTAGGCTCATATATGATTGATGATAGCAATCCCCTTTCGAGAAAATTATAT
    GATGCAACATTAAAGGTATTAACTAAAATACCGACTCCTAATCATACAATTCCTTTTCAT
    GCTGAATTTTTTGTAGATGGTGAGAAGGTTACTTTTTGCGAAATTGCTTCTAGAGTAGGA
    GGAGGGCTGATAAATGATTCCTTCAAATTACTAACTAATATTGATTTACAAAAAACATTC
    GTAAAAAGTCAAATAGGAATTGATTATTTAAATATAATAAAATCTGATAAGAGAACAGCT
    TGGATAACAATTCCTCCTAAAGAAGGAGAATTACTATCTGTTAATTTGTATAAAGATTCA
    TGGGTTGAGAAAGTGAATTTTGATGAGACCTCTATTGGGAGAAGATATAGTGGCGGTGAT
    TATAGCGCTTCTGCTCTTATAGCATATTTGATTAGTGGAACTGATGAAGACGATTTGAAG
    AATAAAATTTTACATATTATTGAGTGGCAAGATAAAAATACAATATATAAAGAGAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPR_RS04850 [old locus tag: spr0969 ]
  • symbol: SPR_RS04850
  • description: ATP-grasp domain-containing protein
  • length: 399
  • theoretical pI: 6.78896
  • theoretical MW: 45862.2
  • GRAVY: -0.302005

⊟Function[edit | edit source]

  • reaction:
    EC 6.-.-.-?  ExPASy
  • TIGRFAM:
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan D-alanine--D-alanine ligase (TIGR01205; EC 6.3.2.4; HMM-score: 34.4)
    and 7 more
    Metabolism Amino acid biosynthesis Other pyrrolysine biosynthesis protein PylC (TIGR03909; HMM-score: 24.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other coenzyme gamma-F420-2:alpha-L-glutamate ligase (TIGR04443; EC 6.3.2.32; HMM-score: 22.6)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis carbamoyl-phosphate synthase, large subunit (TIGR01369; EC 6.3.5.5; HMM-score: 21.8)
    Cellular processes Cellular processes Biosynthesis of natural products cyanophycin synthetase (TIGR02068; EC 6.3.2.29,6.3.2.30; HMM-score: 19.6)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis phosphoribosylaminoimidazole carboxylase, ATPase subunit (TIGR01161; EC 4.1.1.21; HMM-score: 19.2)
    alpha-L-glutamate ligase, RimK family (TIGR00768; EC 6.3.2.-; HMM-score: 18.8)
    Metabolism Energy metabolism Glycolysis/gluconeogenesis pyruvate carboxylase (TIGR01235; EC 6.4.1.1; HMM-score: 10.9)
  • TheSEED: see spr0969
  • PFAM:
    ATP-grasp (CL0179) ATP-grasp_4; ATP-grasp domain (PF13535; HMM-score: 39.3)
    ATP-grasp_3; ATP-grasp domain (PF02655; HMM-score: 35)
    and 6 more
    ATP-grasp; ATP-grasp domain (PF02222; HMM-score: 24.1)
    Dala_Dala_lig_C; D-ala D-ala ligase C-terminus (PF07478; HMM-score: 23.5)
    ATPgrasp_TupA; TupA-like ATPgrasp (PF14305; HMM-score: 21.3)
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain (PF02786; HMM-score: 19.2)
    GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain (PF01071; HMM-score: 17.5)
    RimK; RimK-like ATP-grasp domain (PF08443; HMM-score: 15.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Extracellular
    • Cytoplasmic Score: 0.3013
    • Cytoplasmic Membrane Score: 0.0492
    • Cell wall & surface Score: 0.0015
    • Extracellular Score: 0.648
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.005019
    • TAT(Tat/SPI): 0.000101
    • LIPO(Sec/SPII): 0.000817
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MVKIAIINQFSPRVCDYKAIKELEDKKYEIEIFTKARFKSYYEDSKFKCYFYDNLLDNQNYIFDIIDSHSKKPFTYIVATHEFDIVLAAKIRKLLGISGQNIDSANGFRDKYIMKKYLEKAVSLPKYAEINDCVDLIEFTDNKKYPFVVKPRLGAGSIGVTIIQNKSELKDFISSPLSQNLMVETFTNGEMYHVDGLFKDNEMLLYSVSKYFNDCLSFKTNTPLGSYMIDDSNPLSRKLYDATLKVLTKIPTPNHTIPFHAEFFVDGEKVTFCEIASRVGGGLINDSFKLLTNIDLQKTFVKSQIGIDYLNIIKSDKRTAWITIPPKEGELLSVNLYKDSWVEKVNFDETSIGRRYSGGDYSASALIAYLISGTDEDDLKNKILHIIEWQDKNTIYKEK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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