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serotype 1

NCBI: 26-OCT-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: SPR_RS05635 [old locus tag: spr1128 ]
  • pan locus tag?: PNEUPAN002532000
  • symbol: SPR_RS05635
  • pan gene symbol?: guaC
  • synonym:
  • product: GMP reductase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPR_RS05635 [old locus tag: spr1128 ]
  • symbol: SPR_RS05635
  • product: GMP reductase
  • replicon: chromosome
  • strand: -
  • coordinates: 1131681..1132667
  • length: 987
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    ATGTTAAATGAATTTCCAATTTTTGATTACGAAGATATTCAATTGATTCCAAATAAATGT
    GTCATTAAAAGCCGTGCAGAAGCGGATACAAGTGTCACTTTAGGAAATCACACCTTTAAA
    CTACCTGTTGTGCCAGCGAATATGCAGACGATTTTGGATGAAAATGTAGCAGAGCAACTG
    GCTAAAGGTGGTTACTTCTACATTATGCACCGTTTTGATGAGGCAGGACGCATTCCTTTT
    ATTAAACGAATGCACGATCAAGGGCTCATTGCTTCCATATCTGTCGGTGTTAAGGATTAT
    GAGTATGATTTTGTTAGCCAGCTCAAGGCTGATGCTCCTGAGTATATCACTATTGATATT
    GCTCATGGTCATGCGGATAGCGTGATTTCTATGATTCAACACATCAAGAAAGAATTGCCA
    GATACCTTTGTCATTGCTGGAAATGTGGGAACACCAGAAGCTGTGCGTGAATTGGAAAAT
    GCTGGTGCAGATGCTACTAAGGTCGGAATCGGTCCTGGTAAGGTTTGTATCACCAAGGTT
    AAGACTGGTTTTGGTACAGGTGGTTGGCAGTTGGCTGCTCTACGCTGGTGTGCCAAGGCT
    GCGCGTAAACCGATTATCGCTGATGGAGGAATTCGTACTCACGGTGATATTGCCAAGTCT
    ATCCGCTTCGGTGCTAGCATGATCATGATTGGTTCCCTCTTTGCAGGACACATTGAAAGT
    CCAGGGAAAACGATTGAAGTCGATGGTGAACAGTTCAAAGAATATTATGGTTCAGCCTCA
    CAATATCAGAAAGGTGCTTACAAAAATGTGGAAGGCAAACGTATCTTGCTTCCTGCTAAA
    GGTCATCTGCAAGACACTTTAACTGAGATGGAACAAGACCTTCAAAGTGCTATTTCTTAT
    GCAGGTGGACGTCAGGTTGCTGACCTTAAACACGTTGATTATGTGATCGTGAAAAACTCC
    ATCTGGAATGGGGATGCTTCCCACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    987

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPR_RS05635 [old locus tag: spr1128 ]
  • symbol: SPR_RS05635
  • description: GMP reductase
  • length: 328
  • theoretical pI: 6.58782
  • theoretical MW: 35882.7
  • GRAVY: -0.178049

⊟Function[edit | edit source]

  • reaction:
    EC 1.7.1.7?  ExPASy
    GMP reductase Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions guanosine monophosphate reductase (TIGR01306; EC 1.7.1.7; HMM-score: 644.2)
    and 12 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis inosine-5'-monophosphate dehydrogenase (TIGR01302; EC 1.1.1.205; HMM-score: 183.9)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions guanosine monophosphate reductase (TIGR01305; EC 1.7.1.7; HMM-score: 177.4)
    Unknown function General IMP dehydrogenase family protein (TIGR01303; HMM-score: 145.4)
    Unknown function General IMP dehydrogenase family protein (TIGR01304; HMM-score: 57.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other isopentenyl-diphosphate delta-isomerase, type 2 (TIGR02151; EC 5.3.3.2; HMM-score: 29.6)
    glycosyl amidation-associated protein WbuZ (TIGR03572; HMM-score: 22.4)
    Metabolism Amino acid biosynthesis Histidine family 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase (TIGR00007; EC 5.3.1.16; HMM-score: 19.8)
    Metabolism Amino acid biosynthesis Histidine family imidazoleglycerol phosphate synthase, cyclase subunit (TIGR00735; HMM-score: 18.1)
    Metabolism Amino acid biosynthesis Glutamate family 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase (TIGR01182; EC 4.1.2.14,4.1.3.16; HMM-score: 15.6)
    Metabolism Energy metabolism Entner-Doudoroff 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase (TIGR01182; EC 4.1.2.14,4.1.3.16; HMM-score: 15.6)
    heme/flavin dehydrogenase, mycofactocin system (TIGR03966; EC 1.-.-.-; HMM-score: 14.9)
    geranylgeranylglyceryl phosphate synthase family protein (TIGR01768; EC 2.5.1.-; HMM-score: 13.9)
  • TheSEED: see spr1128
  • PFAM:
    TIM_barrel (CL0036) IMPDH; IMP dehydrogenase / GMP reductase domain (PF00478; HMM-score: 227.6)
    and 10 more
    FMN_dh; FMN-dependent dehydrogenase (PF01070; HMM-score: 29.6)
    His_biosynth; Histidine biosynthesis protein (PF00977; HMM-score: 26.1)
    NMO; Nitronate monooxygenase (PF03060; HMM-score: 26)
    TMP-TENI; Thiamine monophosphate synthase (PF02581; HMM-score: 23.2)
    DHO_dh; Dihydroorotate dehydrogenase (PF01180; HMM-score: 16.8)
    G3P_antiterm; Glycerol-3-phosphate responsive antiterminator (PF04309; HMM-score: 16)
    ThiG; Thiazole biosynthesis protein ThiG (PF05690; HMM-score: 15.7)
    Aldolase; KDPG and KHG aldolase (PF01081; HMM-score: 14.1)
    IGPS; Indole-3-glycerol phosphate synthase (PF00218; HMM-score: 12)
    Glu_synthase; Conserved region in glutamate synthase (PF01645; HMM-score: 12)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.009796
    • TAT(Tat/SPI): 0.000302
    • LIPO(Sec/SPII): 0.001104
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MLNEFPIFDYEDIQLIPNKCVIKSRAEADTSVTLGNHTFKLPVVPANMQTILDENVAEQLAKGGYFYIMHRFDEAGRIPFIKRMHDQGLIASISVGVKDYEYDFVSQLKADAPEYITIDIAHGHADSVISMIQHIKKELPDTFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMIMIGSLFAGHIESPGKTIEVDGEQFKEYYGSASQYQKGAYKNVEGKRILLPAKGHLQDTLTEMEQDLQSAISYAGGRQVADLKHVDYVIVKNSIWNGDASH

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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