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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 25-NOV-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: SPR_RS05665 [old locus tag: spr1133 ]
  • pan locus tag?: PNEUPAN002508000
  • symbol: leuD
  • pan gene symbol?: leuD
  • synonym:
  • product: 3-isopropylmalate dehydratase small subunit

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPR_RS05665 [old locus tag: spr1133 ]
  • symbol: leuD
  • product: 3-isopropylmalate dehydratase small subunit
  • replicon: chromosome
  • strand: -
  • coordinates: 1137026..1137385
  • length: 360
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_003098 (1137026..1137385) NCBI
  • BioCyc:
  • MicrobesOnline: see spr1133
  • PneumoBrowse for strain D39V: SPV_1113 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    ATGGTAGGGTCTTCGAGGGAACACGCTGCTTGGGCTCTAGCGGACTATGGTTTTAAGGTC
    GTGATTGCAGGATCTTTCGGTGACATTCATTACAATAATGAACTCAATAATGGCATGTTG
    CCAATCGTTCAGCCTAGAGAGGTTAGAGAGAAACTAGCCCAGCTAAAACCAACCGACCAG
    GTAACTGTGGACTTGGAACAACAAAAAATCATCTCACCAGTTGAAGAATTCACCTTCGAG
    ATAGATAGCAAGTGGAAACATAAACTCCTAAATAGTTTGGATGATATCGGTATTACCTTG
    CAGTATGAAGAGTTGATTGCTGCTTATGAAAAACAACGACCAGCCTACTGGCAGGATTAG
    60
    120
    180
    240
    300
    360

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPR_RS05665 [old locus tag: spr1133 ]
  • symbol: LeuD
  • description: 3-isopropylmalate dehydratase small subunit
  • length: 119
  • theoretical pI: 4.60358
  • theoretical MW: 13692.4
  • GRAVY: -0.427731

⊟Function[edit | edit source]

  • reaction:
    EC 4.2.1.33?  ExPASy
    3-isopropylmalate dehydratase (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate
  • TIGRFAM:
    Metabolism Amino acid biosynthesis Pyruvate family 3-isopropylmalate dehydratase, small subunit (TIGR00171; EC 4.2.1.33; HMM-score: 121)
    and 7 more
    3-isopropylmalate dehydratase, small subunit (TIGR02087; HMM-score: 51.2)
    Metabolism Amino acid biosynthesis Pyruvate family 3-isopropylmalate dehydratase, small subunit (TIGR02084; EC 4.2.1.33; HMM-score: 43)
    Metabolism Energy metabolism TCA cycle putative aconitate hydratase (TIGR01342; EC 4.2.1.3; HMM-score: 32.4)
    Metabolism Energy metabolism TCA cycle aconitate hydratase 1 (TIGR01341; EC 4.2.1.3; HMM-score: 30.6)
    Metabolism Amino acid biosynthesis Aspartate family homoaconitase (TIGR00139; EC 4.2.1.36; HMM-score: 27.3)
    Metabolism Energy metabolism TCA cycle aconitate hydratase, mitochondrial (TIGR01340; EC 4.2.1.3; HMM-score: 20.4)
    2-methylisocitrate dehydratase, Fe/S-dependent (TIGR02333; EC 4.2.1.99; HMM-score: 10.5)
  • TheSEED: see spr1133
  • PFAM:
    Leu-IlvD (CL0364) Aconitase_C; Aconitase C-terminal domain (PF00694; HMM-score: 74)
    and 3 more
    no clan defined TCAD3; Ternary complex associated domain 3 (PF19972; HMM-score: 12.6)
    AbrB (CL0132) MazE_antitoxin; Antidote-toxin recognition MazE, bacterial antitoxin (PF04014; HMM-score: 12.3)
    NADP_Rossmann (CL0063) Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase (PF07992; HMM-score: 10.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.982
    • Cytoplasmic Membrane Score: 0.0054
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0124
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.009576
    • TAT(Tat/SPI): 0.00101
    • LIPO(Sec/SPII): 0.004871
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MVGSSREHAAWALADYGFKVVIAGSFGDIHYNNELNNGMLPIVQPREVREKLAQLKPTDQVTVDLEQQKIISPVEEFTFEIDSKWKHKLLNSLDDIGITLQYEELIAAYEKQRPAYWQD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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